Category: Vitamin C

Severe Combined Immunodeficiency?- Causes Symptoms & Treatment in Ayurveda

ABSTRACT

Severe combined immunodeficiency is a rare genetic illness that occurs due to genetic abnormalities that disrupt the functional development of B cells and T cells and modify the clinical presentation. Other names for it include Swiss-type agammaglobulinemia, bubble boy disease, and bubble baby disease. There are roughly 13 different genetic disorders that can cause severe combined immunodeficiency. These flaws also make people highly susceptible to life-threatening diseases. Infants with 80% severe combined immunodeficiency do not have a family history of the condition. In this article, we will read briefly about severe combined immunodeficiency.

INTRODUCTION

Severe combined immunodeficiency is an uncommon disorder caused by genetic abnormalities that affect immune cell function and development. Infants with severe combined immunodeficiency appear healthy but are incredibly vulnerable to life-threatening infections. Until or unless newborns undergo immune restoration therapy, such as gene therapy, enzyme therapy, and hematopoietic stem cells.

Severe Combined Immunodeficiency

CAUSES

  1. Common gamma chain of the T-cell receptor deficiency
  2. Recombinase activating genes 1 and 2 deficiency
  3. Adenosine deaminase deficiency
  4. Janus kinase 3 deficiency
  5. Alpha-chain deficiency of the IL-7 receptor
  6. CD3 chain deficiency
  7. Gene mutation
  8. Artemis deficiency

SYMPTOMS

  1. Diarrhoea
  2. Weakness
  3. Oral thrush
  4. Delayed growth
  5. Recurrent infections
  6. Difficulty in weight gain
  7. Pneumonia
  8. Respiratory infections
  9. Failure to thrive
  10. Rashes
  11. Sinus infections
  12. Ear infections
  13. Blood infection

DIAGNOSIS

  1. Complete medical history
  2. Physical examination
  3. TREC test (T-cell receptor excision circle)
  4. WBC count
  5. DNA tests for genetic mutations.

TREATMENT

  1. Bone marrow transplant
  2. Chemotherapy
  3. Gene therapy
  4. Supportive care
  5. Hematopoietic stem cell transplantation

PREVENTION

  1. Prevent baby from infection or a cold
  2. Avoiding public places
  3. Wash your hands properly before touching the infant.
  4. Limiting visitors

AYURVEDIC ASPECT OF SEVERE COMBINED IMMUNODEFICIENCY

In Ayurveda, we can correlate severe combined immunodeficiency with anuvanshik vyadhi (inherited disease) and oja kshaya (immune deficiency). Anuvanshik vyadhi in a person develops at birth as a result of beej dosha (sperm and ovum malformation). Oja refers to immunity or resistance to diseases of two types: one that lessens the manifestation of the disease, and the other variety that prevents the manifestation of diseases. Normal doshas (vata, pitta, and kapha), equilibrium state of dhatu, normal agni, patency of srotas, and other factors that support the equilibrium condition of all physiological parameters are the factors that lead to oja (immunity). Oja is the core of rasadhi dhatus, which is also known as bala (strength).

CAUSATIVE FACTOR OF OJA KASHAY

     अभिघातात् क्षयात् कोपाच्छोकाद्धयानाच्छ्रमात् क्षुधः।

     ओजः सड्.क्षीयते ह्योभ्यो धातुग्रहणनिः सृतम्।

      तेजः समीरितं तस्माद्विस्त्रंसयति देहिनः।। (सु.सू  १५ /२८)

According to Acharya Sushruta, Ojas decreases as a result of any injury or harm.

  1. Body discomfort
  2. Tissue exhaustion
  3. Rage
  4. Grief
  5. Stress
  6. Exertion
  7. Hunger, etc., causes fluid to flow out of the dhatus and become associated with tejas under the control of vata.

CLINICAL FEATURES OF OJA KASHAY

      मूर्च्छा मांसक्षयो मोह: प्रलापोऽज्ञानमेव च ।

      पूर्वोक्तानि च लिङ्गानि मरणं च बलक्षये ।। (सु.सू  १५ /३२)

  1. Fainting
  2. Wasting of muscles
  3. Unconsciousness
  4. Delirium
  5. Death
  6. Improper perception of knowledge

TREATMENT

Oja kshaya and anuvanshik vyadhi are incurable because of improper understanding. We can only provide supportive care using herbal medications to stop the disease from getting worse and provide some immunity to fight against other infections.

HERBAL REMEDIES FOR SEVERE COMBINED IMMUNODEFICIENCY BY PLANET AYURVEDA

Planet Ayurveda is a certified Ayurvedic clinic, and the formulation of different types of remedies is performed here to provide relief from diseases. All formulations at Planet Ayurveda are made organically without the use of preservatives. All of the plants used to make medicine are pure, natural, and extremely effective. Planet Ayurveda offers a variety of herbal products that have no side effects for supporting the treatment of severe combined immunodeficiency.

Herbal Remedies for Severe Combined Immunodeficiency

Ayurvedic treatment for Severe Combined Immunodeficiency

PRODUCT LIST

  1. TELOMERE BOOSTUP
  2. IMMUNE BOOSTER
  3. AMALAKI RASAYAN
  4. ASHWAGANDHA CAPSULE
  5. SHILAJIT CAPSULES
  6. GANDHAK RASAYAN

PRODUCT DESCRIPTION

1. TELOMERE BOOSTUP

Telomere boostup are multi-herbal capsules that are formulated by Planet Ayurveda with the help of Vitis vinifera (Grapeseed), Withania somnifera (Ashwagandha), Amla (Emblica officinalis), and some other ingredients. Ashwagandha prevents all types of weakness, enhances strength and stamina, and improves general alertness. It contains analgesic, aphrodisiac, anti-inflammatory, and diuretic properties. It helps with digestion. It first targets the ama dosha and prevents its buildup. It primarily functions as a rasayana, vajikarana, and ojovardhak, and it also inhibits the production of arbuda and granthi.

Dosage: with plain water, take one capsule twice daily, after meals.

2. IMMUNE BOOSTER

Immune booster is a multi-herbal formulation that is formulated by Planet Ayurveda with the help of Vitis vinifera (Grape seed), Bovine colostrum (Go-Piyushs), Emblica officinalis (Amalaki), and Phyllanthus niruri (Bhumi amla). Bhumi amla is beneficial for liver disease because it normalizes the bilirubin level. It is also beneficial for bacterial and viral infections. It also helps with skin conditions and kidney-related diseases. It consistently strengthens and maintains a healthy immune system.

Dosage: with plain water, take 2 capsules twice daily, after meals.

3. AMALAKI RASAYAN

Amalaki rasayan is a single herbal capsule formulated by Planet Ayurveda with the help of Amalaki (Emblica officinalis). Amla is a rich source of vitamin C, which is helpful in eye diseases. It provides strength to the muscles of the eyes and nourishment to the eyes. Amalaki has a cooling and soothing effect. It helps in pacifying tridoshas and working more on pitta dosha. It has analgesic and anti-inflammatory properties and is also a rich source of natural antioxidants.
Dosage: with plain water, take one capsule twice daily, after meals.

4. ASHWAGANDHA CAPSULE

Ashwagandha capsules are multi-herbal capsules that are formulated by Planet Ayurveda with the help of Withania somnifera (Ashwagandha). Ashwagandha has significant immune-boosting properties. It has been demonstrated to support immune cells that fight infection and reduce inflammation. Ashwagandha is extremely helpful in painful situations like arthritis because it has strong anti-inflammatory qualities.

Dosage: with plain water, take two capsules twice daily, after meals.

5. SHILAJIT CAPSULES

Shilajit capsules are single herbal capsules that are formulated by Planet Ayurveda with the help of Shilajit (Asphaltum). Shilajit is the result of a protracted process of mineral and plant matter degradation. It is a tar-like, sticky substance that comes from rocks and is only present in high mountain areas. Shilajit has been used for a long time to prolong life and slow ageing. The ingredients may help control cognitive problems. It is also beneficial for aging, anemia, antivirals, chronic fatigue, liver cancer, heart health, obesity, and male fertility.

Dosage: with milk or plain water, take 1 capsule twice daily, after meals.

6. GANDHAK RASAYAN

Gandhak rasayan is a single herbal tablet formulated by Planet Ayurveda with the help of shuddha gandhak (Purified sulphur). It is an immunity booster. It acts as an antibacterial, antimicrobial, and anti-inflammatory herb. It pacifies all three doshas, which are vata, pitta, and kapha. It also purifies the blood. It is useful for urinary tract infections and removes harmful pathogens from the body. It increases body strength and boosts immunity.

Dosage: with lukewarm water, 2 tablets twice daily, after meals.

Contact Planet Ayurveda Support Team to provide you the costing/ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 842-749-4030.

CONCLUSION

Severe combined immunodeficiency is a rare genetic illness that occurs due to genetic abnormalities that disrupt the functional development of B cells and T cells and modify the clinical presentation. Infants with severe combined immunodeficiency appear healthy but are incredibly vulnerable to life-threatening infections. In Ayurveda, we can correlate severe combined immunodeficiency with anuvanshik vyadhi (inherited disease) and oja kshaya (immune deficiency). Anuvanshik vyadhi in a person develops at birth as a result of beej dosha (sperm and ovum malformation). In Planet Ayurveda, there are some herbal remedies that are beneficial for the Treatment of Severe combined immunodeficiency without causing any side effects.

Why is Vitamin C necessary for Humans? What happens in its deficiency? What are the Best Sources as per Ayurveda?

Abstract

Vitamin C a well known type of important Vitamin. It is also called Ascorbic acid. Ascorbic acid slows down the rate of cell damage. It is essential for the absorption of iron ( a basic element for body functioning) from plant based foods. Deficiency chances of vitamin C are rare as it is available in a variety of food products. But the unhealthy lifestyle of present days shows deficiency of this important vitamin in many individuals. Scurvy (we will discuss later in this article) is the common disease due to deficiency of Vitamin C. The other associated complaints due to deficiency of Vitamin C are anemia, infection, bleeding gums, dry and splitting hair and impaired wound healing. Vitamin C is essential in the prevention of infection and drains free radicals from the body. Collagen is essential to build and maintain healthy connective tissue. Vitamin C is essential to build good cartilages, immunity, bone strength etc. In this article we will discuss Vitamin C, sources, functions, deficiency of Vitamin C and Ayurvedic sources to maintain the levels of Vitamin C. Citrus fruits are helpful to manage the bleeding, anemia and other associated problems with low levels of ascorbic acid.

Vitamin C

Introduction

Vitamin C is a light weight molecular simple carbohydrate with a idol structure due to which it is water soluble in nature. Vitamin C is synthesized by most of the species. Vitamin C is not stored or produced in the body of humans. So external sources to maintain the good levels of Vitamin C are essential. The requirement of Vitamin C is therefore for the collagen biosynthesis, for the synthesis of L- carnitine and metabolism of protein. Collagen is a very important unit of connective tissue, which is basic and promotes wound healing. The body’s total content of Vitamin- C is from 300 mg up to 2 gram. Vitamin C which is extra stored and maintained in body cells and is highest in W.B.C’s, adrenal glands and brain. An individual needs approx 60 mg of Vitamin C every day. Dosage varies in adults and children. Biotechnology enables the addition of Vitamin C in some juices and other food items. One important fact about Vitamin C is that it is easily destroyed during food preparation or storage. To get proper amounts of Vitamin C from different sources it is important to eat fresh fruits and veggies, cook veggies in little water and avoid over cooking. Vitamin C is soluble in water and found in fruits and veggies. Citrus fruits are the best source of Vitamin C. Foods which are rich in Vitamin C are citrus fruits Kakadu Plums (T. ferdinandiana) contains 5300 mg of Vitamin C per 100 grams, Acerola cherries (Malpighia emarginata) contains 822 mg of Vitamin C per 100 gm, Rose hips contains 119 mg of Vitamin C and supports good skin, chili pepper and guavas are other rich sources of Vitamin C contains 109 mg and 126 mg of Vitamin C per 100 grams.

Basic Chemistry

Ascorbic acid is a 6 carbon organic acid with structural similarity to glucose. It is a potent reducing agent and is biologically active. It is absorbed from GIT and widely distributed extra- and intracellularly. Concentration of Plasma and Vitamin C depend on its intake. The 60 mg/day which is the approx. daily dosage results in 0.8 mg/dl in plasma and 1.5 g in the body as a whole. Human body is able to store 2.5 gram rest which is drained via urination. The stored Vitamin C is oxidized to dehydroascorbic and oxalic acid metabolites. Vitamin C is important for folic acid conversion to folinic acid, adrenal steroids, biosynthesis and promotes metabolism of prostaglandins. Vitamin C was first discovered in 1928 under the name hexuronic acid. Scurvy is the problem associated with deficiency of Vitamin C. Earlier it was very common in the naval forces of the world. At that time it usually affected the sailors. In an experiment in 1747 scurvy of multiple patients was cured with lemons and oranges only. So many animals have a tendency to synthesize Vitamin C on their own. But humans are not able to synthesize Vitamin C on their own. Scurvy is also concerned with the potato famine in Ireland.

Functions of Vitamin C

  • Vitamin C helps to play a vital role in oxidation of tissue.
  • As we read earlier Vitamin C plays an important role in collagen formation.
  • Vitamin C supports matrices for the blood vessels and bones.
  • Helpful for the absorption of Iron.
  • Vitamin C is evident to prevent the cold and infections.
  • Vitamin C is a potent antioxidant known to drain out free radicals from the body.
  • It helps to boost the serotonin level and reduce stress.
  • Vitamin C is helpful to manage dry skin and wrinkles.
  • It is known to boost the noradrenaline levels of a well known neurotransmitter.
  • Also it helps to maintain alertness and confidence.
  • Ascorbic acid helps to relieve the loss of libido due to deficiency of Vitamin C.

Risk factors for low levels of vitamin C

The associated risk factors include smoking, poor socioeconomic level, excessive alcohol intake, diabetic obese or any other metabolic syndrome. People who smoke excessively have more free radicals in their body hence are more prone to the vitamin deficiency.

Deficiency of Vitamin C

Following is the disease or complaints which are associated with Vitamin C deficiency

  • Scurvy – Scurvy simply is a defective formation of collagen, impaired healing, capillary hemorrhage, subnormal platelet adhesiveness, because platelets are rich in ascorbate. Trauma, surgery, burns; infections usually increase the need of Vitamin C. The features of scurvy are as – spongy, bleeding and swollen gums, gastrointestinal tract hemorrhage, anemia and slow wound healing. Scurvy is prevalent among malnourished infants, drug addicts, and alcoholics mostly.
  • Joint and Muscle pain– Vitamin C deficiency may cause excessive pain in the joints or poor bone status. With the pain joints may suffer inflammation or even difficulty in movement. Joint pain is usually countered by vitamin administration.
  • Fatigue – Low body stamina, low energy levels. Unable to do exertion and fatigue can be associated with low levels of Vitamin C. Although fatigue can be the associated symptom of many kinds of illness.
  • Mood Changes – Mood changes, lethargy, emotions and anger can be associated with Vitamin C deficiency. Optimum levels of Vitamin C promote a good mood and self esteem.
  • Weight LossWeight loss can be associated with deficiency of Vitamin C. A person suffering from weight loss may focus on natural sources of Vitamin C.
  • Bruising – Bruising is associated with deficiency of Vitamin C.
  • Dry Hair and Skin – A change in hair and skin texture can also signal that the body is not getting enough of vitamin C and other essential vitamins and minerals.
  • Infections – Poor or deprived status of Vitamin c enhance the exposure towards multiple infections, the low level of Vitamin C tends to deprive the Low levels of vitamin C in the body can have a negative impact on the fighting of infections. This occurs due to the body’s weak immune system. It may also cause chronic low energy, strength and depression. Even bone strength is affected.

Sources for Vitamin C

Ayurvedic texts upload the advantages of healthy living. A quote in Ayurveda is very famous i.e ‘Aharam param bhaishjam’ means food is the best medicine. In the context of Vitamin C we can discuss Phalvarga, a category under Aharvarga. Acharya sushruta has mentioned Dadima (pomegranate), Amlaka (Embellica officinalis), Draksha (Vitis vinifera), Kharjura (Phoenix dactylifera) and Matulunga (Citrus medica). Here we will discuss the natural sources of Vitamin C. Vitamin C is soluble in water and found in fruits and veggies. Citrus fruits are the best source of Vitamin C. The other sources are pepper, blackcurrants, strawberries, broccoli and potatoes. 3 large strawberries contain approx 35 gm Vitamin C. Other foods which are rich in Vitamin C are Kakadu Plums (T. ferdinandiana) contains 5300 mg of Vitamin C per 100 grams, Acerola cherries (Malpighia emarginata) contains 822 mg of Vitamin C per 100 gm, Rose hips contains 119 mg of Vitamin C and supports good skin, chilli pepper and guavas are other rich sources of Vitamin C contains 109 mg and 126 mg of Vitamin C per 100 grams. All these sources are also rich in antioxidants and lycopene.

1. Citrus Fruits

Lemon and oranges are the rich sources to supplement Vitamin C naturally in the body. Citrus fruits help to enhance immunity. Citrus fruits are helpful to maintain the skin’s health and elasticity. These fruits are helpful due to anti-inflammatory and antioxidant activity. In one lemon there is approximately 83 mg of vitamin c, one orange which is medium in size contains 70 mg of Vitamin C. Grapefruit contains 44 mg of Vitamin C.

2. Papaya

Papaya contains 235 mg of vitamin C. papaya has more vitamin C than orange. Papaya is a fibrous fruit. It helps to drain out the toxins and harmful chemicals. It enhances the vitamin C levels so it is able to prevent skin acne and pigmentation. Papaya is rechak (purgative) in nature.

3. Amla

Amla is a well known fruit or berry having plenty of ayurvedic medicines. It is one of the richest sources of Vitamin C. It helps to enhance the level of vitamins in the body. The fruit contains higher concentration of vitamin c than apple. The leaves of amla contain gallic acid, ascorbic acid and music acid. It also helps to reduce the level of cholesterol and helps to detoxify the channels of the body. Amla is an anti-anaemic, anabolic, antiemetic agent. It also prevents the body from various infections and inflammations.

4. Cruciferous Vegetables

Cruciferous vegetables like cabbage, broccoli, cauliflower etc are the rich source of Vitamin C. In broccoli there is 89 mg of vitamin C and in cabbage and cauliflower there is 36 mg and 48 mg vitamin C respectively. People who are smokers should opt for these vegetables to reduce the free radicals. The fibrous content of the cruciferous vegetables help to relieve constipation and promotes better absorption of nutrients.

5. Guava

Guava also contains ample amounts of Vitamin- C. It helps to boost Vitamin C and increase the defensive strength of the body. Also it is one of the best fruits to solve the abdominal issues. Single fruit of guava is loaded with 200 mg of ascorbic acid.

6. Strawberry

Strawberry contains a good level of ascorbic acid and antioxidants. It is beneficial to manage the heart concerns, diabetic management and make the bowel movements better. As we have discussed earlier 100 grams of strawberries contain approx 59-60 mg of ascorbic acid. Strawberries promote a good mood and soothing effect.

7. Terminalia Chebula

T chebula is a well known purgative. It is one of the important constituents of Triphala churna. It is rich in Vitamin C hence has a good mutagenic activity. Haritaki promotes the purification of the body due to its purgative action. It is also called as a rejuvenator and Vataanulomya’ drain out the excessive vata from the body.

8. Tinospora Cordifolia

T. cordifolia is a good source of vitamin C and helps to inhibit the rate of infections in the body. Giloy is a well known immunity booster and a classical rejuvenator. It promotes the defensive line against the invaders or pathogens. Regular use of giloy helps to enhance the stores of vitamin C in the body.

9. Taro Plant (Colocasia Esculenta)

It is also called the Yam plant. It is widely distributed in the northern part of India. It is loaded with flavones, apigenin, Vitamin C and luteolin. Cooked leaves of this plant are a good source of dietary fiber and relieve constipation. It is astringent and styptic. It is beneficial in alopecia as well as promotes anti-ageing effects.

10. Boerhavia Diffusa (Punarnava)

B diffusa is a well known herbal plant known to promote good health and prevent the conditions associated with low levels of Vitamin C like Anaemia , stunted growth. It helps to promote  the mood, increase the hb level in the body. It is diuretic in action and rich in ascorbic acid, and acts as an anti-inflammatory agent. Also it contains flavonoids and lowers down the uric acid levels in the body.

11. Mucuna Pruriens (Kaunch beej)

M pruriens is an astringent, nervine tonic, local stimulant. It is rich in ascorbic acid and flavonoids. Seeds of kaunch containing L-DOPA help to enhance the serotonin levels. It enhance the male sexual health and manage the problems arised due to deficiency of Vitamin C. kaunch helps to promote the activity of central nervous system.

12. Cordia Dichotoma (Lasoda)

The basic ingredients of the C dichotoma are alpha-amyrin, ascorbic acid, calcium, iron, copper and chromium. It is astringent in nature, demulcent, expectorant, diuretic and antihelminthic. It is helpful to manage the problems associated with diabetes. It manages the lower levels of semen associated with deficiency of Vitamin C.

Conclusion

In the above discussion it is clear that Vitamin C is one of the most essential vitamins for the body. It helps to maintain cell growth. It is best to enhance bone strength, open the channels and increase immunity. The variety of products of Planet Ayurveda promotes the good levels of Vitamins in the body. Vitamins promote longevity, are anti-aging in nature, promote glow and are rejuvenators in action. Lower level of Vitamin C may lead to poor sexual health and poor status of sperm count or spem motility. It is important to opt for natural sources of vitamins. The fruits like amla if consumed on a regular basis enhance the Vitamin C levels easily. Balanced diet, natural lifestyle, herbal solutions of problems is helpful for a good life and promotes longevity. In case of any query kindly visit www.planetayurveda.com.