Category: Juvenile idiopathic arthritis

Abstract

Amyloid Polyneuropathy also known as Familial Amyloid Polyneuropathy (FAP) is a group of hereditary amyloidosis that cause malfunctioning of sensory or autonomic functions of the body due to the deposition of amyloid protein in peripheral nerves. Polyneuropathy means the malfunctioning of many nerves simultaneously due to aggravated amyloid. The prevalence of Amyloid Polyneuropathy worldwide is not known. The death rate is high in prolonged cases. Treatment is essential for sensorimotor, autonomic, and visceral complications. Let us have a look and find out its causes and how it can be managed by Ayurveda.

Introduction

Amyloid Polyneuropathy is caused due to deposition of amyloid proteins in the peripheral nerves. Amyloid is an insoluble protein that aggregates in blood vessels and nerves. Various amyloid proteins particularly cause disease progress. Amyloid proteins can aggregate in any vessel of the body example – amyloid deposition in cardiac muscles can cause cardiomyopathy, deposition of amyloid proteins in urinary/genital nerves can cause urogenital disorders, deposition of amyloid proteins in ocular nerves can cause ocular manifestations, and so on. Amyloid Polyneuropathy is a severe disease. It may include several manifestations altogether that make it difficult to handle. The chemicals used for its treatment may worsen other symptoms in the body. So here in this article, we will discuss some ayurvedic treatment methods that can help in managing these conditions naturally without any side effects.

Ayurvedic Aspect

Imbalance of tridosha and the aggravation of toxins in the body cause neuropathies. The imbalance occurs due to improper lifestyle and food practices. This leads to Rakt dushti and Sira dushti (vitiation of body nerves and blood due to deposition of amyloid proteins). Oral herbal medicines and external therapies together are effective in the recovery of sensory and autonomic functions. Rasayan herbs are used along with particular medicines for symptomatic relief. Proper pathya apathya is indicated according to a person’s condition. Brihana drugs are used to nourish nerves from the inside and reduce the deposition of amyloid protein by initiating its excretion from the body, which will improve the overall condition of the patient. A proper detailed description of herbal medicines and their action on the body are discussed further in this article.

Causes

• Most of the cases are seen arising genetically as its genes are autosomal dominant and cause mutations. Inherited Amyloid Polyneuropathy is caused due to mutation in proteins – TTR, Gelsolin, and apolipoprotein A1.
• Not all Amyloid neuropathy is genetic however, some are caused by the deposition of paraprotein, lymphomas, and myelomas.

Symptoms

There are sensory and autonomic dysfunctions in Amyloid Polyneuropathy that may include symptoms like

• Sensory loss of pain and temperature
• Weight loss
• Cardiac problems
• Numbness
• Hypotension
• Difficulty in balancing
• Sexual dysfunction
• Eyesight issues
• Renal complications
• Gastrointestinal disorders
• Urinary disorders
• Persistent nausea
• Vomiting
• Diarrhea
• Sweating
• Constipation

Diagnosis

Diagnosis is confirmed after clinical and laboratory examinations

• Electromyography
• Skin biopsy
• Nerve biopsy
• Muscle biopsy
• Blood testing for genetic evaluation
• Immunocytochemistry
• Nerve conduction test
• Quantitative sensory testing (QST)
• Antenatal diagnosis is possible through chorionic villus sampling

Treatment

The treatment requires multiple modalities according to the symptoms and the type of amyloid protein the person is suffering from.

Symptomatic Treatment

• Neuropathic treatment by a neurologist (with antidepressants, anti-seizure drugs, etc.)
• Cardiologist for cardiac problems
• Liver surgeon for liver problems
• Ophthalmologist for ocular dysfunctions

Organ transplants are recommended in severe cases

Herbal Remedies for Amyloid Polyneuropathy Disease by Planet Ayurveda

Ayurvedic treatment can be very effective in its management. Various herbs help manage these conditions naturally. The medicines prepared from these herbs if pure can ease the symptoms. Planet Ayurveda offers 100% pure medicines for its treatment. All medicines either tablets, capsules, or syrups are made from standard extracts of the herbs. No adulteration is done. Fabulous outcomes have been recorded from reviews of patients throughout the world, who have recovered from such diseases, with our medicines.

Planet Ayurveda offers Treatment of Amyloid Polyneuropathy with their potential herbal formulations listed below

1) Boswellia Curcumin

This patent formulation is prepared with Turmeric (Curcuma longa) and Shallaki (Boswellia serrata). These herbs increase immunity and also act as an antioxidant. Their anti-inflammatory action is helpful in bone and joint inflammatory diseases. Boswellic acid and curcuminoids present in these capsules work by inhibiting topoisomerase and reducing brain edema, which helps release brain relaxants and reduce tension because of joint pain. These capsules ease symptoms of brain and joint deformities.

Dosage – Have 2 capsules twice daily after meal with plain water.

2) Neurogenie capsules

These capsules are made from extracts of Brahmi (Bacopa monnieri) – whole plant, and Ashwagandha (Withania somnifera) – roots. Both of these herbs are very efficient in treating brain disorders as well as increasing the overall immunity of the body. They can help the person to fight against such disorders by giving mental and physical strength to the person.

Dosage – Have 1 capsule twice daily after meal with plain water.

3) Ekangivir Ras

This ayurvedic medicine is in tablet form. It is prepared with Shuddha gandhak (Purified sulfur), Loh bhasma (Iron), Kanta Loha bhasma (Manganese calx), Pippali (Piper longum), Haritki (Terminalia chebula), Bibhitaki (Terminalia bellerica), Amla (Emblica officinalis), trikatu, Kusha (Saussurea lappa), etc. This medicine is very specifically used in nerve deformity-related disorders like sciatica, cervical, paralysis, polyneuropathy, etc. It has rejuvenating, anti-toxic, and nourishing properties. Its dose is recommended by the doctor according to your symptoms and is reduced or increased in amount accordingly.

Dosage – Eat 1 tablet twice daily after meal with plain water.

4) Chandraprabha Vati

This vati is composed of herbs such as – Shilajit (Asphaltum), Guggul (Commiphora mukul), Karpoor (Cinnamomum camphora), Mustak (Cyprus rotundus), Sharkara (Sugar), Vacha (Acorus calamus), Chavya (Piper chaba), Haridra (Curcuma longa), Amalaki (Emblica officinalis), Vidanga (Embelia ribes), shunthi (Zingiber officinalis), Maricha (Piper nigrum), Danti (Baliospermum montanum), Dalchini (Cinnamomum tamala), Ela (Elettaria cardamomum), etc. These vatis treat neuropathy in the urogenital system. Also, they help in conditions like indigestion, bronchitis, piles, etc. their main mode of action is managing problems related to the urinary tract.

Dosage – Eat 2 tablet twice daily after meal with plain water.

5) Telo Extension Capsules

These capsules are made up of Ashwagandha (Withania somnifera), Amla (Emblica officinalis), Moringa (Moringa oleifera), Pine bark (Pinus longifolia), Grapeseed (Vitis vinifera), Giloy (Tinospora cordifolia) and Rose hip (Rosa indica). These capsules work on the whole body functioning due to their rejuvenating (Rasayana) properties. These herbs nourish nerves from the inside and help to deal with polyneuropathies.

Dosage – Have 1 capsule twice daily after meal with plain water.

6) Moringa Capsules

These are prepared with standard extracts of Moringa (Moringa oleifera). These capsules are hot in action due to Pitta pradhan herb. It helps to balance gastrointestinal problems in amyloid neuropathy. They balance Vata and Kapha dosha in the body and help in normal metabolism and overall functioning of gastrointestinal neuropathy.

Dosage – Take 1 capsule two times daily after meal with plain water.

7) Vrihat Vatchintamani ras

This ayurvedic medicine is made up of Swaran bhasma (Gold ash), Rajat bhasma (Silver ash), Prawal (Coral calcium), etc. These are dietary supplements manufactured to maintain normal mental and physical health. Primarily this medicine is indicated in paralytic patients, epilepsy, psychosis, etc conditions. It helps to maintain a healthy nervous system.

Dosage – Chew 1 Tablet daily after meal.

Conclusion

Many single herbals and polyherbal medicines are used in the management of amyloid polyneuropathies. Allopathy drugs used can have various adverse effects in addition to temporary relief. Thus, it could be concluded that ayurvedic treatment has much more potency for complete and permanent effects in such conditions