Ayurvedic Treatment of GNE Myopathy


GNE Myopathy is an inherited neuromuscular disorder that affects the skeletal muscles. Skeletal muscles share 30-40% part in the total mass of the body. These muscles are connected to the bones and provide a wide range of functions and movements. These muscles work with voluntary actions (the person feels like doing it on their own). In this study we are going to discuss all about GNE Myopathy and how it affects the skeletal muscles. Also if any of you feel that you are facing the symptoms that we are going to mention in the article don’t worry just go through this study and get the solution of your problem out of it as we are going to discuss the best treatment by Ayurveda in this article. Now I have a detailed view on GNE Myopathy.



GNE Myopathy is the condition in which there is an inherited neuromuscular default. It occurs by the mutation (change) in the GNE gene. This gene plays a great role in the generation of sialic acid, which is the type of sugar required by muscle cells for producing energy. The condition is inherited via an autosomal recessive pattern. Autosomal recessive condition means two defective gene mutations must be there to cause a disorder. This is the main cause of GNE Myopathy. As this is an inherited condition which means it is present since birth. And most commonly it affects the skeletal muscles and restricts its functions. So after reading all about this condition, if you feel you are suffering from the same condition don’t worry you will also get your solution here. So In this article we are going to discuss all about GNE Myopathy and its Ayurvedic management.

Symptoms of GNE Myopathy

Symptoms of GNE Myopathy most probably appear in the 2nd and 3rd decade of life and may experience the following symptoms:

  • Progressive muscle wasting
  • Severe disability
  • Bilateral foot drop (difficulty in lifting the front part of the foot)
  • Disturbed gait
  • Decreased stability
  • Frequent falls
  • Difficulty in climbing stairs
  • Difficulty in running
  • Difficulty in rising up from the seated position

Causes of GNE Myopathy

As we read earlier, the main cause of GNE Myopathy is gene mutation and the gene mutation is of recessive type. In general the condition occurs due to transfer of defective genes from both the parents but if the person receives one normal and one defective gene then the patient is considered as the carrier of the disease but is asymptomatic. Symptoms usually appear when the genes from both parents are defective. Risk of having both defective genes is 25% and risk of having one defective gene is 50%. Also if one parent is experiencing GNE Myopathy and one parent is a carrier of GNE Myopathy then there is also a 50% chance risk to the child.

Diagnosis of GNE Myopathy

Most of the patients after appearing symptoms are diagnosed clinically after seeing such symptoms like foot drop, frequent falls, progressive muscle wasting. If a doctor is not able to be diagnosed clinically then a patient must be advised for genetic testing. Genetic testing should be done with simple non-invasive procedures muscle biopsy  by the help of saliva or blood sample. Additionally, MRI, pulmonary function tests, and echocardiogram are considered as the options to confirm the diagnosis.

Ayurvedic View of GNE Myopathy

According to Ayurveda GNE Myopathy is correlated to beeja dosha, which means the condition occurs with the defect in beejbhaga (sperm and ovum). Ashudh shukra and Ashudh artava (defected sperm and defected ovum) are considered as  the main causes of this condition. If there is any defect in the gametes (sperm and ovum) of parents then the child should inherit the disease. Beeja dosha due to the fact that if the mother conceived when her uterus or artava (gamete) is not totally vitiated but troubled by imbalanced doshas because of her improper diet intake. If there is any defect due to beej bhaga then cause beeja dosha and the deformity will occur in the fetus. As it is an inherited disease so we may treat the symptoms of the disease but not totally cure it. There are some natural herbs that cure the symptoms of the disease and make the affected person’s life better by improving the quality of life.

Ayurvedic Treatment of GNE Myopathy

As we discussed earlier, GNE Myopathy is an inherited disease so we may treat the symptoms of the disease and manage the quality of life of the patient. So the treatment according to Ayurveda is done to promote the neurological functions in the body, and the dosha responsible for neurological functions is vata, so the main purpose of treatment is to balance the vata dosha in the body and promote the functions of the whole body. So if anyone reading this article is facing the same condition then they must choose to improve their quality of life by Ayurvedic treatment. For this purpose we are sharing with you the herbal treatment by planet Ayurveda and for knowing about the treatment by planet Ayurveda must read the next study.

Ayurvedic Treatment by Planet Ayurveda for GNE Myopathy

Planet Ayurveda is a GMP certified clinic which provides treatment for a wide range of diseases. All their remedies are formed under the guidance and supervision of M.D. Ayurveda doctors and 100% purely vegetarian. Also while formulating their remedies they take care that any kind of added synthetic material should not be added to it like any sort of resins, fiber, color, preservatives and all. For managing GNE Myopathy, planet Ayurveda listed 7 herbal remedies. Further we are going to discuss all about these herbal remedies and how it benefits the GNE Myopathy patients.

  1. Ashwagandhadi Ghrit
  2. Musli Strength Capsules
  3. Boswellia Curcumin
  4. Yograj Guggul
  5. Atirasadi Churna
  6. Rasraj Ras
  7. Balaswagandhadi Thailam

Products Description

1. Ashwagandhadi Ghrit

Ashwagandhadi ghrit is a herbal remedy in the paste form. It includes several ingredients such as ashwagandha (Withania somnifera), bibhitaki (Terminalia bellirica), go ghrita (cow’s ghee), go dugdha (cow’s milk) and water. It helps in balancing the vata dosha and instigating its normal functioning. So by balancing vata dosha the neurological functions also get improved. By managing the neurological functions the symptoms of GNE Myopathy also get improved.

Dosage: 1 Tsp twice daily with lukewarm water after meals. 

2. Musli Strength Capsules

This herbal remedy is available in capsules form and consists of standardized extracts of  safed musli (Chlorophytum borivilianum) and gokshura (Tribulus terrestris). Safed musli is known for its rasayana (rejuvenates cells) and bruhmana (nourishing) properties. Gokshura consists of madhura rasa (sweet taste) and madhura ras is  also nourishing in nature.   Both these herbs are very best in providing strength to the muscles and hence prevents the progressive muscle wasting in GNE Myopathy.

Dosage: 1 capsule twice daily with plain water after meals.

3. Boswellia Curcumin

Boswellia curcumin is also present in capsule form and contains standardized extract of boswellia (Boswellia serrata) and curcumin (Curcuma longa). Both these herbs are very best in pacifying vata dosha and show miraculous results in neurological disorders, most effectively helpful in reducing pain. So by balancing vata dosha it aids in managing the  symptoms of GNE Myopathy.

Dosage: 2 capsules twice daily with plain water after meals.

4. Yograj Guggul

This herbal remedy includes guggul (Commiphora mukul), musta (Cyperus rotundus), chitrak (Plumbago zeylanica), amalaki (Emblica officinalis), bibhitaki (Terminalia bellirica), haritaki (Terminalia chebula), and many other herbs. The herbs included in yograj guggul are beneficial in detoxifying the body and  in strengthening and rejuvenating the skeletal muscles by pacifying vata dosha. Also it promotes the healthy immune system of the body. Yograj guggul shows its main effect in alleviating the pain in neurological conditions.

Dosage: 2 capsules twice daily with plain water after meals.

5. Atirasadi Churna

This herbal remedy is present in the powder form and includes the powders of several herbs such as- safed musli (Chlorophytum borivilianum), kali musli (Curculigo orchioides), semal musli (Salmalia malabarica), gokshura (Tribulus terrestris), Shatavari (Asparagus racemosus), ashwagandha (Withania somnifera), and many other herbs. Most wonderful effect of this churna is the rasayana effect (rejuvenating effect). Most neurological disorders are corrected by the rejuvenating therapy so by adding this churn in the treatment of GNE Myopathy will help in promoting the health of the patient in GNE Myopathy by rejuvenating the nerve cells, by strengthening the muscles and also by improving the muscle mass of the patient.

Dosage: 1 teaspoon twice daily with warm milk after meals.

 6. Rasraj Ras

This a classical ayurvedic formulation mentioned in ras tantra sar and siddha yoga sangraha. It consists of several ingredients such as- parada (purified mercury), abhraka (purified silica), swarna (calyx of gold), loha bhasma (calyx of iron), rajata bhasma (calyx of silver), vanga (calyx of tin) and many other ingredients. This is a rasa preparation. Rasa preparation is prepared by minerals and metals and these preparations are very much helpful in promoting the health of the patient. Rasraj ras is considered very beneficial in promoting the health of the patient in neurological condition as the ingredients used in this preparation are rasayana which helps in rejuvenating the neurological cells which in turn alleviates the symptoms of the person in GNE Myopathy.

Dosage: 1 tablet twice a day to be chewed.

7. Balaswagandhadi Thailam

This is also a classical formulation mentioned in sahasrayogam. This formulation includes bala (Sida cordifolia), ashwagandha (Withania somnifera), sesame oil (Sesamum indicum), manjishtha (Rubia cordifolia), sariva (Hemidesmus indicus), ushira ( Vetiveria zizanioides) and many other ingredients. This oil is for external use. Application of this oil in case of GNE Myopathy will improve muscle strength and promote the functioning of muscles and make people able to perform their day to day activities.

Dosage: Take a few drops of oil and apply it over affected parts of the body.



GNE Myopathy is an inherited neuromuscular disorder that affects the skeletal muscles. It occurs by the mutation (change) in the GNE gene. In general the condition occurs due to transfer of defective genes from both parents. According to Ayurveda GNE Myopathy is correlated to beeja dosha, which means the condition occurs with the defect in beejbhaga (sperm and ovum). Progressive muscle wasting, Severe disability, Disturbed gait, Decreased stability, Frequent falls, Difficulty in climbing stairs, Difficulty in running, in short a person is unable to perform day to day activities. So if you are facing these issues, you must choose Ayurveda treatment. It will improve your quality of life and make you better to perform day to day activities. For this purpose planet Ayurveda is there for you with a miraculous list of herbal remedies, then stop worrying and start taking Ayurvedic medicine to improve your day to day life.

What is GNE MYOPATHY? – Causes, Diagnosis & Ayurvedic Treatment


GNE myopathy is a hereditary illness that mostly affects the skeletal muscles. It is also known as HIBM, Nonaka myopathy, IBM2, and distal myopathy with rimmed vacuoles. The disease’s earliest symptoms develop between the ages of 20 and 40, and it affects both men and women at the same rate. Progressive muscular weakness, which often increases over time, decreasing grip strength, and frequent loss of balance are all symptoms of this illness. There is currently no cure for the condition, and therapy focuses on symptom management. Ayurveda, on the other hand, may aid in the management of this ailment.


GNE myopathy is a hereditary muscle disorder in which GNE refers to the defective gene. It is a rare condition that affects around one person in a million individuals throughout the globe. It causes muscle weakness and atrophy in the legs and arms. The beginning of symptoms is generally in young adults, however, some people have seen a later onset. Foot drop is generally associated with increased tripping and a steppage gait at first. The problem worsens with time, resulting in proximal leg muscular weakness, difficulty ascending stairs or rising from a seated position and weakening of the hands and shoulder muscles.

How an you recognize myopathy’s indications and symptoms?

  • Disturbed gait and impaired stability are common in GNE myopathy patients, as are frequent falls, difficulties ascending stairs, jogging, and getting up from a sitting posture.
  • The muscles of the lower limbs are the first to be damaged, with the exception of the quadriceps, which seem to be largely unaffected.
  • Neck muscles might be impacted in the latter stages of the illness.
  • Finally, as the illness progresses, skeletal muscle function may be lost completely, leaving the patient completely reliant on others.

Acquired myopathies may exhibit symptoms that are comparable to hereditary myopathies, as well as the following

  • Muscle deterioration
  • Motor sluggishness
  • Impairment of the respiratory system
  • Dysfunction of the bulbar muscles (malfunction of the muscles responsible for swallowing and speech)

Causes of GNE myopathy


Changes (mutations) in the GNE gene, which codes for the enzyme glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, cause GNE myopathy. Infection, muscular damage, medicines, electrolyte imbalances, and thyroid illness are among the other reasons.


GNE myopathy testing is appropriate for patients who have foot drop (in young adults) and distal extremity muscle weakness (in those who have advanced stages of the illness). Genetic testing is an excellent initial step in determining the severity of GNE myopathy in individuals. This includes the use of minimum or no invasive treatments, simply requiring a blood or saliva sample, and yielding results in hours or days.

Factors at Risk

Some myopathies, such as some forms of muscular dystrophy, are hereditary. Other myopathy risk factors include:

  • Myasthenia gravis, scleroderma, and thyroiditis are examples of autoimmune diseases.
  • Endocrine problems
  • Toxin exposure, such as pesticides and flame-retardant chemicals
  • Infections
  • Deficiency in vitamins
  • Antihistamines and long-term corticosteroids are among the drugs used.
  • Glycogen and lipid storage disorders are examples of metabolic diseases.

Treatment with Ayurveda

It is considered an incurable myopathy, with mortality occurring between the ages of 20 and 25. Modern science has limits in treating the ailment, but Ayurveda has a lot of promise in treating diseases that are incurable. Ayurveda may assist in maintaining a healthy range of motion for all of the body’s joints. Toxins are removed from the body, the doshas are balanced, and the body cells and muscles are rejuvenated to promote strength and flexibility. Yoga and meditation sessions are used in addition to treatment methods to increase blood circulation to all body parts and joints. These reduce the likelihood of acquiring additional medical problems while also enhancing respiration and other critical bodily processes.

A healthy food plan is also arranged for optimal nourishment that assists in muscle growth as well as overall body development. A well-balanced diet may assist to soothe inflamed doshas and bring the body’s critical systems and hormone levels back into equilibrium. Herbal decoctions for internal ingestion are given in addition to therapy regimens to assist ease symptoms. And that’s what the world’s leading Ayurveda industry, Planet Ayurveda offers us.

Description of the product

1. Ashwagandha Ghrit

It’s great for muscular fatigue, stiffness in the neck or back, exhaustion, joint problems, and arthritis of any kind. It also helps with anxiety, tension, and depression. The main ingredient of this formulation includes Ashwagandha (Withania somnifera).

Dosage: 1 tsp twice a day in warm water

2. Musli Strength

Safed Musli (Chlorophytum borivilianum) and Gokshura (Tribulus terrestris) are used in this herbal medicine. It aids in the enhancement of growth hormone circulation in the blood. This also aids in the development of muscle growth and strengthening to help in reducing GNE myopathy effects.

Dosage: 1 capsule twice a day

3. Boswellia Curcumin

Boswellia Curcumin seems to be helpful in lowering inflammation, alleviating arthritis symptoms, and increasing muscular strength. Shallaki (Boswellia serrata) and Curcumin (curcuma longa) are the main ingredients in this herbal combination that can help to get relief from GNE myopathy.

Dosage: 2 capsules twice a day

4. Yogaraj Guggul

Yograj Guggulu contains herbs including Chitraka (Plumbago zeylanica), Shuddha Guggulu (Commiphora mukul), Ardraka (Zingiber officinale), Pippali (Piper longum), Haritaki (Terminalia chebula), and others that may help reduce pain and enhance joint and muscular mobility, which following useful to get rid from GNE myopathy.

Dosage: Take 2 tablets  twice a day

5. Atirasadi Churna

Gokshura (Tribulus terrestris), Ashwagandha (Withania somnifera), Nutmeg, Shatavari (Asparagus racemosus), Kali Musli (Curculigo orchioides), Safed Musli (Chlorophytum borivilianum), and Varahi Kand (Dioscorea bulbifera) are some of the components in Planet Ayurveda’s Atirasadi Churna. It primarily aids in the development of stamina, and the strengthening of weak muscles. Moreover, it helps in the reduction of tension, and the reduction of worry.

Dosage: 1 tsp twice a day with warm milk is the recommended dosage.

6. RasRaj Ras

It is an Ayurvedic medication for neuromuscular diseases, as well as nerve and muscle strengthening. Ashwagandha Churna (Withania somnifera), Rasa sindura (purified and processed Mercury), Swarna Bhasma (Gold Bhasma), Loha Bhasma (Iron Bhasma), Rajata Bhasma (Silver Bhasma), and Vanga Bhasma (Tin Bhasma) are some of the herbs found in it.

Dosage: 1 chewable tablet once a day.

7. Bala Ashwagandha Oil

The oil’s rejuvenating effects help muscles to relax, nerves to tone, and nerve conduction to improve. It is used to relax the muscles while gently stroking them.

Dosage: For external use only.

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The negative effects of long-term allopathic medicines and therapies that produce GNE Myopathy might be addressed with these herbal combinations. As a result of the inefficacy of allopathic therapy. Start with Planet Ayurveda to purchase a real Ayurveda product if you want to learn more about the therapy. They may be reached at or their clinic in Mohali, Punjab.