Category: Common variable immune deficiency

Treatment of Autoimmune Lymphoproliferative Syndrome With Herbal Remedies


Autoimmune lymphoproliferative syndrome also known as ALPS is an autoimmune inherited disease in which the body cannot properly regulate immune cells i.e lymphocytes. It is an autoimmune condition where there is the production of large no. Of abnormal lymphocytes in short there is the proliferation of lymphocytes. There are high no. Of white blood cells or lymphocytes in the lymph nodes, liver and spleen which further causes enlargement of these organs. It causes some clinical manifestations in patients in later stages and affects males more than females. The disorder mainly manifests in the first few years of life. In this article we will discuss the ayurvedic aspect of ALPS and how it can be managed using various Ayurvedic herbs.

autoimmune lymphoproliferative syndrome


Autoimmune lymphoproliferative syndrome is an autoimmune disorder which causes overproduction of lymphocyte cells which build-ups in the lymph nodes, liver and spleen. ALPS is limited to the hematopoietic system but some other organs like liver and kidneys are also involved. The symptoms involved are fatigue, nosebleeds and infection results from proliferation of lymphocytes and destruction of other blood cells. Sometimes new gene defects can occur with no history of any infection. If genetic change occurs at the time of conception it is called sporadic but if it occurs in later stages the gene mutation affecting the blood cells is called a somatic variant which is not passed onto the next generation. When it causes damage to other organs it causes skin rashes, mouth sores, vasculitis and neurological symptoms.


ALPS is an inherited disease caused by mutation in the FAS gene and is of autosomal dominant manner. While some of the cases are inherited in an autosomal recessive manner. Sometimes it is caused by somatic mutation in the lymphocytes and is not inherited. Mutation in the FAS gene leads to abnormality in the activation of programmed cell death or apoptosis which is said to be an important part of normal cell life cycle. The mutation causes the immune system to remain active without even the presence of infection.


Symptoms will vary from person to person depending on the type of organ getting affected which later on gives rise to lymphadenopathy and splenomegaly. The increased proliferation of abnormal lymphoid cells can give rise to lymphadenopathy.

  • Rashes
  • Anemia
  • Fatigue
  • Fever
  • Infection
  • Swollen lymph nodes in armpit and groin region

Majority of patients do not get lymphoma but some are at higher risk of getting the cancer of white blood cells. Lymphoma causes symptoms like fever, weight loss, rashes and enlargement of lymph nodes.


As per ayurveda the syndrome comes under the autoimmune disorders which are directly related to the ama or endotoxins produced in the body. These toxins further lead to the development of ama in the whole body which start obstructing the path of the various bodily channels. These channels mainly get obstructed by the movement of doshas from kostha (GI tract) to shakha (all bodily dhatus like Ras, rakta, mamsa, meda, asthi, majja and shukra) and skin. This transfer of ama or toxins from dhatus and kostha lead to the deposition of toxins in various bodily organs like liver, spleen and lymph nodes causing their enlargement and develops lymphadenopathy and splenomegaly in later on stages.

Ayurveda explains about the dhusti of majja dhatu or bone marrow in this syndrome where the white blood cells Lymphocytes are born where ama or toxin imbalances the majja dhatu agni (digestive fire) and causes proliferation of lymphoid cells. There is the vitiation of strotas or channels with ati pravriti (excess production) causing proliferation of lymphocytes. These will further get deposited in the lymph nodes and give rise to lymphadenopathy.

The main Ayurvedic treatment regimen is done for removing the obstruction from the channels with haridra (Curcumin longa), improving one’s immunity by adding immune booster herbs like giloy(Tinospora cordifolia) and balancing the majja dhatu agni.   


This syndrome is generally diagnosed by taking one’s history and laboratory examination.

  • Family history of  ALPS
  • Elevated plasma  vitamin B12 level
  • Polyclonal hypergammaglobulinemia (IgG, IgA)
  • Elevated plasma interleukins
  • Anemia
  • Thrombocytopenia
  • USG or CT Scan for Lymphadenopathy and Splenomegaly
  • People with ALPS are at risk of developing Lymphoma


The main course of treatment is done to manage the autoimmune condition by adopting medicinal treatment like

  • Corticosteroids  like Methylprednisolone
  • Intravenous Immunoglobulins (IvIg)  
  • Rituximab
  • Rapamycin like mTOR inhibitor for reducing Lymphoproliferation and lymphadenopathy
  • Surgery for surgical removal of spleen like Splenectomy

Herbal Remedies for ALPS by Planet Ayurveda

Planet ayurveda provides various ayurvedic herbal formulations to various diseases which are helpful in managing the condition of various health ailments. These herbal formulations are made up of 100 percent natural ayurvedic herbs free from any type of side effects and preservatives and can be taken by people of any age group. Out of all of those herbs some of them are used to manage this autoimmune lymphoproliferative syndrome (ALPS) given below

  1. Giloy Capsules
  2. Curcumin Capsules
  3. Immune Booster
  4. Navkarshik Churna


Product’s Description

1. Giloy Capsules

These capsules are made up of herb giloy (Tinospora cordifolia) which is said to be good for improving immunity. It has madhur(sweet), ushna(hot) and katu (pungent) and has deepana (appetizer) and pachna (digestive) properties to balance the digestive fire and reduce toxins from the channels.

Dosage– 1 capsule twice daily after meal.

2. Curcumin Capsules

These capsules are formed of herb like haridra(Curcumin longa) which has anti-inflammatory and antioxidant properties. It overall improves immunity and maintains healthy blood circulation in the body. It reduces pain and inflammation from the body. 

Dosage– 1 capsule twice daily after meal.

3. Immune Booster

This herbal formulation is made up of herbs like amalaki (Emblica officinalis), Bhumi amla (Phyllanthus niruri), gau piyush (Bovine colostrums) and grape seed (Vitis vinifera) which are having antioxidant properties and will protect the tissues from the free radical damage.

Dosage– 1 capsule twice daily after meal.

4. Navkarshik Churna

This herbal formulation is made of different herbs like Triphala (Emblica oficinalis, Terminalia chebula, Terminalia bellirica) , Vacha (Acorus calamus), Neem (Azadirachta indica), Katuki (Picrorhiza kurroa) and various other herbs. Neem is having tikta(bitter), laghu(light) and ruksha(dry) gunas to reduce the obstruction from the concerned channels and improves the blood flow. Vacha is considered to be medhya and possess laghu(light), tikshna(sharp) guna to have a rejuvenating effect on the body. While triphala will balance all three doshas in the body.

Dosage– 1 tsp twice daily after meal.


Autoimmune lymphoproliferative syndrome or ALPS is an inherited autoimmune condition which affects the lymphoid cells and causes its proliferation by destroying the other immune cells. It can be caused by hereditary effects or mutation in genes. Ayurveda mainly focuses on treating the cause of the disease or nidanparivarjna or managing autoimmune like conditions by reducing ama or toxins from the body. The herbs mentioned above are good for managing the ALPS condition which are free from any types of side effects and free from addictive chemicals and can be consumed by people of any age group. In case of any query kindly visit . For more queries, you can send your queries to our email id

Ayurvedic Treatment For Autoimmune Lymphoproliferative Syndrome


Autoimmune lymphoproliferative syndrome is a rare genetic disorder of the immune system. In this syndrome an abnormally high number of white blood cells (lymphocytes) gathers in lymph nodes, liver and spleen, thus leading to increase in size of these organs. Autoimmune lymphoproliferative syndrome causes anemia (decreased RBCs), thrombocytopenia (decreased platelets) and neutrophils. In this article we are going to discuss Autoimmune lymphoproliferative syndrome in detail and the ayurvedic aspect as well as ayurvedic treatment of the disease.

autoimmune lymphoproliferative syndrome


Autoimmune lymphoproliferative syndrome is a rare disease of genetic disorders of the immune system. In this syndrome the body cannot counter the lymphocytes, thus results in excessive production of lymphocytes and cause gathering of lymphocytes, thus enlargement of lymph nodes, liver and spleen. This syndrome increases the risk of cancer of lymphoma. Autoimmune lymphoproliferative syndrome is generally caused by mutation of FAS gene in an autosomal dominant manner. In some cases there are somatic mutations. Autoimmune lymphoproliferative syndrome mainly causes decrease in white blood cells, red blood cells and platelets. Treatment includes medications, blood transfusion and splenectomy. In Autoimmune lymphoproliferative syndrome there is dysregulation in programmed cell death, i.e. there is delay in signal from brain to death of the cells. As there is delay in cell death so there is excessive accumulation of cells that cause abnormal buildup of white blood cells.


  • Inherited
  • More prone in adulthood

Ayurvedic Aspect of Disease

Autoimmune lymphoproliferative syndrome is a Raktaj and pittaj predominance vyadhi (disease). In this disease there is raktaj dusti so there is dorbalya (weakness), urdhav raktpitt (epistaxis), raktalpata (anemia) with pittaj predominance. All these symptoms show raktaj and pittaj predominance. Therefore all the treatment depends upon pacifying raktaj and pittaj dosha.

Causes of Autoimmune Lymphoproliferative Syndrome

  • Inherited
  • Unknown
  • Mutations in FAS gene.

Symptoms of Autoimmune Lymphoproliferative Syndrome

  • Fatigue
  • Epistaxis
  • Infections
  • Destruction of white blood cells (neutropenia)
  • Destruction of red blood cells (anemia)
  • Thrombocytopenia (low platelets)
  • Generalized weakness

Diagnosis of Autoimmune Lymphoproliferative Syndrome

  • Medical history (family history)
  • Physical examination
  • Blood test
  • Lymphadenopathy
  • Double negative T cells
  • Biopsy

Complications of Autoimmune Lymphoproliferative Syndrome

  • Inflammation of the liver (hepatitis)
  • Kidney inflammation (glomerulonephritis)
  • Uveitis

Treatment of Autoimmune Lymphoproliferative Syndrome

  • Immunosuppressive medications
  • Immunoglobulin therapy
  • Blood transfusion
  • Bone marrow transplant
  • Splenectomy

As in allopathic medications have their side effects when consumed for a long time and this affects other organ damage and some serious complications. Ayurvedic medicines help in treating the disease from the root cause and helps in managing the disease. Allopathic medicines reduce the symptoms of disease but not treat the disease from its root cause whereas ayurvedic medicines help in treating the disease from the root. Ayurveda helps in pacifying the tri dosha of the body and also maintains the pachak agni (digestive fire) of the body as mentioned by our Acharyas Charaka and sushruta.

Ayurvedic Treatment of Autoimmune Lymphoproliferative Syndrome by Planet Ayurveda

Planet Ayurveda is a globally recognized firm that provides best herb formulations to the patient because it extracts pure raw materials from the herb and makes a 100% genuine product with no side effect and best overall result since 20 years. In Ayurveda, one of the best methods to overcome this is to pacify the dosha in the body. Planet Ayurveda provides the best Ayurvedic medicines to treat the imbalanced tri dosha. Ayurvedic medicines help in resolving the disease from its root and maintain a balanced life. By ayurvedic medicines the reoccurrence of disease is minimized and there is no side effect of the ayurvedic treatment. Planet Ayurveda’s products are pure vegetarian and naturally extracted from the herb and medicinal plant. Planet Ayurveda strictly follows the government guidelines for making their product best.

The following herbal remedies from planet Ayurveda are:

  1. Giloy Capsules
  2. Curcumin Capsules
  3. Immune Booster
  4. Navkarshik Churna


Product Description

1. Giloy Capsules

Major ingredient is Giloy (Tinospora cordifolia) which is a pure extract of Giloy. Giloy capsules helps in soothing the inflammation in mucous membrane in the digestive tract and helps in production of mucin in stomach. Giloy capsules are helpful in urinary infections. Giloy shows effective results in mental health, weakness, pyrexia and flu related problems.

Dosage: 1 capsule twice daily with plain water after a meal.

2. Curcumin Capsules

Major ingredient is Haridra (Curcuma longa) which is a pure extract of curcumin. Curcumin acts as an anti- cancerous property as it neutralizes free radicals. Curcumin acts as an anti-inflammatory agent and is helpful in healing minor to major injuries and wounds. This helps in diabetes and is also helpful in preventing allergies. Curcumin also acts as anti aging as it nourishes the skin and makes it free from any type of infections.

Dosage: 2 capsules twice a day with plain water after a meal.

3. Immune Booster

Major ingredients are – Grape seed, Go – Piyush (Bovine colostrums), Bhumi amla (Phyllanthus niruri) Amalaki (Emblica officinalis).Immune Booster capsules are effective in respiratory tract infections and boosting immunity. This helps in eliminating the body’s toxins from the body. It helps in improving the immune system. These capsules give the best result in old age patients as their immunity is weak.

Dosage: 1 capsule twice a day with plain water after a meal.

4. Navkarshik Churna

Major ingredients are Amla (Emblica officinalis), Haritaki (Terminalia chebula), Bibhitaki (Terminalia bellerica), Manjistha (Rubia cordifolia), Katuki (Picrorhiza kurroa), Giloy (Tinospora cordifolia) etc. Navkarshik churna helps in relieving pain. It acts as a blood purifier as it acts as an antibacterial and anti-infection agent. Navkarshik churna also strengthens  joints  and helps in reduction in uric acid

Dosage: 1 teaspoon thrice a day after a meal with plain water.


In this article we have discussed the Autoimmune lymphoproliferative syndrome and also the ayurvedic aspect of disease as well as ayurvedic treatment of disease. Ayurveda helps in curing the disease from the root cause and helps in maintaining a healthy lifestyle. Ayurveda is an ancient therapy which helps to cure the patient by the root cause and also helps the patient to attain a healthy lifestyle. According to Ayurveda there should be the balance of tri dosha and also stated that imbalance of tri dosha causes disease. Thus ayurveda treatment is side effects free and also helps in maintaining a healthy life. For more details of our products check out our website and for queries you can send your queries to our email id