Category: Diabetes & Complications

What is Fasting Insulin and its significance for Diabetic patients?

Abstract

Diabetes mellitus is a non communicable disease but is spreading like a pandemic all over the world. Each and every house is having at least two members who are diagnosed with diabetes. The commonest type of diabetes is diabetes mellitus type 2 but the patients of diabetes type 1 are also increasing day by day. Diabetes mellitus is a clinical syndrome that is characterized by hyperglycemia due to absolute or relative deficiency of insulin. In this article we will mainly discuss the significance of fasting insulin with respect to insulin dependent Diabetes Mellitus or diabetes type 1 and also non insulin dependent diabetes or diabetes type 2.

Introduction

Diabetes is worldwide in distribution and the incidence of both types of primary diabetes, i.e insulin dependent diabetes mellitus (IDDM) or diabetes mellitus type 1 and non insulin dependent diabetes (NIDDM) or also known as diabetes mellitus type 2. However prevalence of both varieties varies considerably in both parts of the world. This Seems to be due to differences in both genetic and environmental factors. To Begin with almost certainly the term diabetes mellitus embraces a heterogenous group of disorders having differing modes of inheritance. Agreement appears to be near at hand that IDDM and NIDDM exhibit substantial genetic differences.

Diabetes mellitus

Stages of Diabetes

1. Overt or manifest diabetes

It refers to the fully expressed clinical syndrome. This stage of disease is characterized by fasting hyperglycemia, glucosuria and usually three p’s that are polyuria, polydipsia and polyphagia.

2. Subclinical diabetes

Subclinical diabetes is understood when the patient is completely asymptomatic and fasting blood glucose level is usually normal but the post prandial level (glucose levels after two hours of meal) is frequently elevated.

3. Latent or stress diabetes

These patients are at the risk of developing overt diabetes. It basically refers to a person who is completely asymptomatic and under ordinary condition is normoglycemic and has a normal glucose tolerance. But under stress like pregnancy, infection and other serious conditions temporary carbohydrate intolerance develops.

4. Prediabetes or potential diabetes

This is a conceptual state which can be applied only retrospectively to the period of time preceding carbohydrate intolerance.

Pancreatic pathology for insulin dependent diabetes mellitus

Three outstanding features characterise the pathological picture of prediabetic pancreas in IDDM

  1. ‘Insulitis’ which  is the infiltration of the islets with mononuclear cells.
  2. The initial patchiness of this lesion with, until a very late stage, lobules containing heavily infiltrated islets commonly seen immediately adjacent to unaffected lobules.
  3. The striking beta cell specificity of the destructive process within infiltrated islets where the glucagon and other hormone secreting cells invariably remain intact.

Things about insulin

Insulin is a peptide hormone secreted by beta cells in pancreatic islets of langerhans and its main function is to lower the serum glucose levels and hence promote anabolism. It is a normal growth factor required for development.  Glucose production and secretion by the liver is strongly inhibited by high concentration of insulin in the blood. Decrease or absence of insulin activity results in diabetes mellitus of either type 1 or type 2. Human insulin protein is composed of 51 amino acids and has a heterodimer of an A- chain and a B-chain which are linked together by disulfide bonds.

Fasting insulin

What is fasting insulin?

Fasting insulin is the name given to a diagnostic test which is used to measure the amount of insulin in blood. As mentioned before insulin is very much important for utilization of blood glucose and hence maintaining rights levels of it. In absence of insulin a condition called hyperglycemia usually occurs. So determining correct levels of insulin in blood is necessary so as to evaluate what exactly is the condition.

Insulin test preparation

Fasting insulin requires at least 8 hours of fasting. This means that before giving a blood sample, a patient should have not eaten anything for around 8 or more than 8 hours.

Purpose of fasting insulin

  1. To find reasons for hypoglycemia
  2. Diagnosing insulin resistance
  3. To find out tumors on the pancreases.
  4. This tumor is called insulinoma.

Test results showing insulin resistance or no insulin resistance

  1. If your body cells have developed insulin resistance then fasting insulin is more than 48pmol/L.  
  2. If your body cells are not having any kind of insulin resistance then fasting insulin is 18-48 pmol/L.

Importance of fasting insulin with respect to hyperglycemia or both form of diabetes

Insulin as mentioned earlier is very important as it is responsible for glucose take up by the cells. Our body cells like cells of muscle tissue, cells of various organs use glucose as a source of energy. They are having specific insulin receptors. Insulin is attached to these receptors and hence the glucose is binded to it. Then this glucose is taken up by the cells which then convert it into energy or store it for later use as a source of energy. But if these receptors do not determine insulin than glucose uptake by the cells does not take place or in other scenarios due to pancreatic cell destruction as a result of the autoimmune process there is absolute deficiency of insulin resulting in hyperglycemia.

So, advising fasting insulin is of great importance in both above mentioned cases. Reason is, this test help in determining:

  1. The exact levels of insulin in body
  2. Determining the type of diabetes especially in case of children
  3. Deciding the type of diet which can be followed
  4. Determining the units of insulin which are to be administered.

Conclusion

Diabetes is no doubt setting its roots deep and deeper into our society. Though we have many effective ways to deal with this group of conditions but still it becomes challenging with each and every patient diagnosed. It is very important to understand that this condition is related to both genetic and environmental factors along with some personal habits. Moreover insulin, whose deficiency is the main reason for hyperglycemia cannot be generated through medicines but its requirement is fulfilled by administration of synthetic insulin.

Natural Treatment of Syringoma (benign adnexal tumor)

Abstract

To the casual observer, the skin is a passive, somewhat dull body’s covering. Celebrated for its flexible, soft, elastic qualities, this covering is surprisingly resistant to corrosive liquids, blunt trauma, effects of harmful light and other radiations. The basic framework of the skin includes epidermis, basement membrane zone overlying dermis and subcutaneous fat. Moreover, the appendageal structures include pilosebaceous units, apocrine and eccrine glands situated in the dermis but are in the connection with epidermis as they are arised from it during embryonic life. The adnexal tumors are the group of tumors like lesions or tumors arising from these pilosebaceous structures, eccrine and apocrine ducts and glands. One of such benign adnexal tumors is Syringioma. This article is focused on this disease and its best Ayurvedic management.

Introduction

Syringoma is a benign adnexal tumor derived from intraepidermal eccrine (acrosyringium). Recently, the transitional portion between the dermal duct and acrosyringium or lower acrosyringium origin have been also believed  as origins. Syringoma is more prevalent in young women approaching or after puberty. The most frequent type is although the localized variant of syringoma in eyelids of middle-aged women.

Sign and Symptoms

Syringoma is a benign adnexal tumor derived from intraepidermal eccrine (acrosyringium). Recently, the transitional portion between the dermal duct and acrosyringium or lower acrosyringium origin have been also believed  as origins. Syringoma is more prevalent in young women approaching or after puberty. The most frequent type is although the localized variant of syringoma in eyelids of middle-aged women.

Sign and Symptoms of Syringoma

Causes

Syringioma can be hereditary transmissible. The postzygotic somatic mutations or mutations within the zygote are considered responsible for the familial or unilateral syrigioma that may or may not affect gonadal mosaicism in the affected patients. Other causes of Syringomas are overactive sudoriferous glands, obstruction in the channels/ducts of eccrine glands. Further, the risk factors include history of diseases like  Marfan syndrome, Down syndrome etc. People with oily skin and patients of Diabetes mellitus are prone for developing Syringoma.

Ayurvedic Aspect

Syringioma in Ayurveda can be understood as a kushtarog (skin disorder) arised due to the svedvaha srotas dushti (vitiation of microchannels/ ducts associated with sweat).

Charka Samhita Vimana

(Reference- Charka Samhita Vimana sthana 5/7)

The basic seats of Sved Vaha srotas are meda(subcutaneous fat) and lomkoop (pilosebaceous glands/ducts) according to Acharya Charka. This vitiation of sved vaha srotas due to underlying cause will lead to the deformities in meda and lomkoop, and will lead to the formation of these papules under the influence of vitiated tridosha predominantly pitta dosha.

Treatment of Syringoma

Planet Ayurveda Is Globally Emerging And Leading Herbal Manufacturing Company Of India That Formulates Various Herbal Or Herbomineral Products With Strict Adherence To Ancient Ayurvedic Texts And Principles. The Products Formulated Here Are Obtained From 100% Natural Sources. These Products Are Made Under The Supervision Of The Expert Team Led By Ayurvedic Doctors With Ancient Time Tested Formulas.Herbal Supplements for Syringoma

Ayurvedic Medicines for Syringoma

Herbal remedies as suggested by Planet Ayurveda’s experts for the management of Syringoma

  1. Kanchnaar Guggul
  2. Manjishtha Capsules
  3. Dermo Plan Syrup
  4. Arogyavardhini Vati

Product Description

1. Kanchnaar Guggul

This tablet is the best classical poly herbal formulation having anti-inflammatory properties. Due to the presence of

  • kanchnar (Boerhavia diffusa)
  • varun (Crataeva nurvala)
  • (Commiphora mukul)
  • haritaki (Terminalia chebula)

This formulation is very much beneficial in opening up the obstruction in the sved vaha srotas and opening the channels to promote better blood supply to the affected part and gradually dissolving the papules of syringoma and preventing its recurrence.

Dosage– 2 tablets twice daily, with water after meals, (to be crushed well or chewed well before use)

2. Manjishtha Capsules

Manjistha (Rubia cordifolia) standardised extract  is the sole ingredient of these capsules. Manjistha is best known for its blood detoxifying abilities in the body that help in pacifying the Pitta dosha hence aids in cleansing the Swedovaha srotas and thus by reducing the overfunctioning of eccrine glands it helps in treating and preventing the further transmission of Syringioma.

Dosage– 1 capsule two times a day after meal with plain water.

3. Dermo Plan Syrup

This syrup is formulated by Planet Ayurveda’s experts for treatment of various skin related issues. This syrup’s contents include

  • Manjistha (Rubia cordifolia)
  • Chopchini (Smilax china)
  • Giloy (Tinospora cordifolia)
  • Haridra (Curcuma longa)
  • Neem (Azadirachta indica)
  • Shigru (Moringa oleifera) etc herbs.

Dermo Plan syrup helps in Syringoma by purifying the blood and helps in maintaining the normal functioning of pilosebaceous glands and ducts by detoxifying the associated channels.

Dosage– 2 teaspoons with equal quantity of water, twice daily after meals.

4. Arogyavardhini Vati

It is the classical tablet formulation having best results in liver and skin disorders. The ingredients of this tablets include include Katuki (Picrorhiza kurroa), along with abhrak bhasma (clax of mica), triphala (combination of the three fruits i.e.

Emblica officinalis, Terminilia chebula, and Terminalia bellerica), sudh shilajatu (detoxified Asphaltum), sudh guggul (purified Commiphora mukul), tamra bhsama (clax of copper), loh bhasam (clax of iron) etc. ingredients. The triphala is very much helpful in eliminating the ama (endotoxins), further the anti-inflammatory and analgesic properties of this tablet helps in various acne and other skin related problems. The antioxidants present in the tablet helps in scavenging the free radicals and its antipruritic nature helps in relieving the itching related issues. Thus this tablet is best suited for the treatment of syringoma.

Dosage– 2 tablets twice daily with water after meals.

Contact my assistant to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214030

Conclusion

Skin tumors are the most common tumors encountered in day-to-day life. Syringoma is a benign and relatively harmless tumor of the skin that may be attributed to the more frequent medical care seeking due to cosmetic reasons in women. In Allopathic medicine, they focus on steroidal therapy or local application of corticosteroids which on long term use have severe hazardous effects on skin as well as on the whole body. Further, if this treatment plan doesn’t succeed they suggest for surgical excision of these papules. But that too have many post-surgical complications and the chances of recurrence is quite high. So, the best method of treatment of these Syringoma is with Ayurvedic herbal medicines, along with some modifications in diet and lifestyle.