Category: Digestive Health

Treatment of Strongyloides stercoralis hyperinfection syndrome

Abstract

Strongyloides stercoralis is a very small nematode which parasites the mucosa of the upper part of the small intestine, often in large numbers.the eggs hatch in the bowel but only larvae are passed in the feces. In moist soil they moult and become the infective filariform larvae. After penetrating human skin they undergo a development cycle similar to that of hookworms but the female worms burrow into the mucosa and submucosa. Some larvae in the intestine may develop into filariform larvae which may then penetrate the mucosa or perianal skin and lead to auto infection and a very persistent infection. In this article we will mainly discuss the hyperinfection due to  Strongyloides stercoralis and what symptoms it creates along with its Ayurvedic management.

Introduction

Strongyloides is the parasite that has more prevalence in the tropical and subtropical regions of the world. Hyperinfection syndrome due to these parasites is ensured in patients that are having imapired cell mediated immunity. Imapaired cell mediated immunity is common in patients who are being administered with steroidal treatment and with drugs which are responsible for immune system suppression. Hyperinfection syndrome only happens when there is acceleration of the normal life cycle of S. stercoralis increasing the worm burden within the reproductive route.Then wide spread of the larvae of this parasite takes place out of the gut area involving organs like heart, liver, brain and urinary tract.

Strongyloides stercoralis hyperinfection syndrome

Clinical manifestation of Strongyloides stercoralis hyperinfection syndrome

The symptoms are similar to classic strongyloidiasis which includes nausea, vomiting, diarrhea, abdominal pain, weight loss, GI hemorrhage, cough, fever and difficulty in breathing. But in case of hyperinfection with accelerated life cycle of parasite catastrophic clinical manifestations like shock, intravascular coagulation, meningitis, respiratory and renal failure.

Moreover, major anatomical changes take place in the duodenum and jejunum. The parasites can be identified in the crypts of lieberkuhn and in mucosa and deposited eggs are sometimes present in the depths of these burrows. The inflammatory action is quite variable and only in the more severe instances is there a mixed leukocytic infiltration, characteristically containing many eosinophils. Much of this infiltration may be attributable to secondary infection.

Diagnosis

The diagnosis of this condition is usually done after examining the stool. Sterile slides are made for filariform larvae. Due to accelerated activity usually parasites are being diagnosed in the stool test. Moreover, a complete blood count is done to take a complete idea of infection and its severity. Urine tests can also be advised.

Treatment

The first line of treatment for strongyloides include ivermectin which eradicated around 80% of parasites. Other agents include thiabendazole and albendazole. In case of shock patients need in door admission along with fluid replacement therapy. Administration of antibiotics through intravenous routes can also be done. If patients have low hemoglobin levels immediate administration of blood units is required.

Herbal Remedies by Planet Ayurveda

Planet Ayurveda is a leading herbal manufacturing unit which manufactures herbal products that are very effective in managing multiple conditions. These products are manufactured using potent herbs and are prepared under the guidance of expert Ayurvedic doctors. The manufacturing team works under their guidance to avoid any kind of compromise with product quality. Our products do not contain any kind of fillers, additives, adulterants and are totally safe to use without any side effects. The herbal products are manufactured using potent and efficient herbs.

Herbal Remedies for Strongyloides stercoralis hyperinfection syndrome

Buy Now

Following are the products offered by Planet Ayurveda for the management of Strongyloides stercoralis hyperinfection syndrome

  1.  Wormistop capsules
  2.  Sanjivani Vati
  3.  Mahashankh Vati
  4.  Digesto plan syrup
  5.  Giloy Capsules
  6.  Curcumin capsules

Products Description

1. Wormistop capsules

Wormistop has constituents like palash (Butea monosperma), tulsi (Ocimum sanctum),  sonth (Zingiber officinale) and vidang (Piper retrofractum). As the product name suggests it is very effective in removing parasites from the intestine and eradicates around 80-90% of worms from the human intestine. It also improves digestion and soothes the mucosa of the intestine.

Dose: Two capsules twice  a day after meals.

2. Sanjivani Vati

Sanjivani vati is known as a medication that infuses life. This is a classical ayurvedic formulation consisting of sonth (Zingiber officinale), haritaki (Termenalia chebula), giloy (Tinospora cordifolia) and many others. It helps in getting rid of accumulated endotoxins and also helps in removing worms from intestines. It creates such an environment in the bowel which is not fit for the survival parasite hence leading to parasite free bowel.

Dose: Two tablets twice a day after meals.

3. Mahashankh Vati

This is a classical formulation having constituents like pancha lavana (five types of salts), shankh bhasma (ashes of pearl), pippali (Piper longum)  and many others. These Help in reducing symptoms related to the digestive system like pain in abdomen, indigestion, worms in intestine, acidity and gastritis. Shankh bhasma in this is very effective in treating chronic constipation and also helps in removal of parasites from intestine by creating a non favourable environment.

Dose: Two tablets twice a day after meals.

4. Digesto plan syrup

Digesto plan syrup is an ultimate composition of herbs like amalaki (Emblica officinalis), haritaki (Terminalia chebula), bibhitaki (Terminalia bellerica) and others. This syrup is potent in reducing anorexia, indigestion and abdominal pain. It improves digestion and has abundant healing features. It helps in balancing toxins in the digestive system which creates a favorable environment for parasite growth.

Dose: Two tsp twice a day after meals.

5. Giloy Capsules

Giloy (Tinospora cordifolia) is an amazing herb that helps in improving the immunity of the body. It also behaves as an immunomodulator in immune-compromised cases. Giloy is an amazing herb that works according to the way your body needs it due to its vichitra pratya rabdha property. Giloy is very much safe to use in any age group.

Dose: Two capsules twice a day after meals.

6. Curcumin capsules

Curcumin capsules are made from the curmin extract of haridra (Curcuma longa). Haridra has amazing properties like it behaves as an antibacterial, anthelmintic, and also bears analgesic features. This formulation is very effective in dragging out worms from the intestine and also helps in enhancing the immunity of the body.

Dose: Two capsules a day after meals.

Contact Planet Ayurveda to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214030 Or Check Website – www.PlanetAyurveda.com

Conclusion

Strongyloides stercoralis hyperinfection syndrome is a condition which ultimately is the result of strongyloides infection ignorance. Patients must stay alert and should notice general symptoms related to worm infestation because long term ignorance can be deadly.

Best Herbal Alternatives to Mesalamine for Ulcerative Colitis Treatment

Abstract

Ulcerative colitis is a chronic relapsing inflammatory bowel disease. It is an inflammation of the large intestine specifically in the colon. It causes ulcers and inflammation in the intestines. This disease mostly affects the innermost lining of the intestines. But it can also affect the whole length of the colon. This inflammation produces tiny sores which is called ulcers and spreads upward direction also. This further causes your bowel to move rapidly and empty frequently. Ulcer causes bleeding and discharge of mucus through anal region. It is an autoimmune disorder and affects people of all ages. The most common drug used in the treatment of UC is mesalamine, but this drug has many side effects also. So in this article we are going to discuss mesalamine and its alternative in Ayurveda.

Introduction

Mesalamine is an Anti-inflammatory drug. It is the active component of sulfasalazine. This drug probably inhibits prostaglandins and leukotriene synthesis. Mesalamine is the official name given to 5-ASA (aminosalicylic acid). 5-ASA is the active moiety in ulcerative colitis, but this drug is not effective orally. So it has been coated with pH sensitive acrylic polymer. This coated formulation delivers 5-ASA to the small intestine and colon.

ulcerative colitis causes

Pharmacokinetic

Mesalamine is not absorbed orally until it is coated with acrylic polymer. It is metabolized in the liver and excreted from urine. Its half-life is 0.5-10 hour. The action of this medicine is hampered in the patient who is suffering from renal diseases.

Dosage

2.4 gm dose has been found in the improvement of the symptoms of ulcerative colitis. Mesacol (Mesalamine) is available in following formulations and doses:

  1. Mesacol 400 mg
  2. Mesacol 800 mg
  3. Mesacol 1.2 grams
  4. Mesacol enema 4 g/60 ml.

Adverse effects

  • Nausea
  • Abdominal pain
  • Headache
  • Fever
  • Fatigue
  • Flatulence
  • Dizziness
  • Acne
  • Nephrotoxicity

Contraindications

It is contraindicated in

  • Hepatic and renal impairment
  • It should not be taken with glucocorticoids and sulfonylureas as it causes gastric toxicity and also increases the hypoglycemic action of sulfonylureas.
  • Also there are interactions with furosemide, spironolactone, methotrexate and rifampicin.

Uses

  • Ulcerative colitis
  • Crohn’s disease

The physician advised the patient that he/she had to live on the medicine for lifelong. Only dose adjustment is there either in lower dosage or higher dosage as per the patient symptoms. Long term use of this medicine causes hepatic and renal impairment.

Alternatives in Ayurveda

Ayurveda is the oldest holistic science. It treats various acute and even chronic diseases. This science treats the disease from its root cause. It provides two best formulations which are good alternatives to mesalamine. These two formulations include Kutaj ghan Vati and Vatsakadi Churna. These two herbal formulations have proven better for ulcerative colitis disease. This Ayurvedic medicine is much more effective than mesalamine and doesn’t cause any side effects as mesalamine does.

herbal supplements for ulcerative colitis

herbal supplements for ulcerative colitis1. Kutaj ghan vati

  1. This is a classical Ayurvedic formulation. It is made from the standardized extracts of Kutaj (Holarrhena antidysenterica). This herb is used in treating acute or chronic diarrhea. As the name suggests dysenterica it is mainly used in diarrhea, dysentery. This is the best herbal supplement for ulcerative colitis. Severe forms of diarrhea, dysentery, bleeding can be cured with the regular use of kutaj ghan vati. This provides proper functioning to the intestines. It provides complete relief from the symptoms of inflammatory bowel disease.

Chemical composition

Seeds of kutaj contain five main alkaloids

  • Conessine
  • Isoconessimine
  • Conessimin
  • Conarrhimin
  • Conimin

These alkaloids have antidysenteric and anthelmintic properties

Ayurvedic properties of Kutaj (Raspanchak)1

1. Ras (taste) – tikta (Bitter), kshaya (Astringent)

These two tastes help in pacifying pitta dosha and helps in stoppage of bleeding from stools.

2. Guna (properties) – Laghu (light), Ruksha (dry)

These properties help in balancing the vata dosha and stop the spread of this disease. This herb is easy to digest

3. Virya (potency) – Sheet (Cold)

This cool potency is helpful in ulcers and bleeding condition

4. Vipaka (post digestion effect) – katu (Pungent)

This pungent property helps in digestion and provides anti-inflammatory action

5. Karma (uses)

Piles, diarrhea, dysentery, mucus, skin disorders

2. Vatsakadi Churna

This is an Ayurvedic classical formulation. It provides strength to the digestive system naturally. It contains Kutaj (Holarrhena antidysenterica) and Bilva (Aegle marmelos). These two herbs are very beneficial in digestive disorders. This formulation is best to check diarrhea, gas formation and irregular bowel movements.

This formulation is used in treating mucus formation

1. Ras (taste) – tikta (Bitter), kshaya (Astringent)

Helps in stoppage of bleeding from stools and mucus.

2. Guna (properties) – Laghu (light), Ruksha (dry)

It is easily to digest and treat ulcers

3. Virya (potency) – ushna (hot)

It is helpful in improving digestion

4. Vipaka (post digestion effect) – katu (Pungent)

It improves digestion and stimulates digestive fire

5. Karma (uses)

Piles, diarrhea, dysentery, mucus

Conclusion

As mentioned above in the article mesalamine is having many side effects that leave very serious impacts on the body especially on our immune system. Our immune system is responsible for protecting our body from various kinds of infection and disorders and any impairment in our immune system can lead a person towards drastic conditions. So it’s better to use Ayurveda treatment because it does not cause any side effects and also treats the disease from its root. So above mentioned two best herbal formulations are effective in inflammatory bowel disease.

References

  1. Bhavprakash nighantu, Guduchyadi varga/118