Category: Eyes Care

Herbal Remedies For Amyloid Corneal Degeneration

Abstract

Amyloid Corneal Degeneration is the degeneration due to amyloid deposits in the various layers of the cornea. Amyloids basically refer to the group of proteins characterized by a fibrillary morphology, extracellular, proteinaceous deposits found in organs and tissues. Amyloid structurally consist of repeated units of β-sheet structure. It can be correlated with Avarna Shukra in Ayurveda as it basically contains corneal opacities discussed later on in this article.

INTRODUCTION

Polymorphic amyloid degeneration is a bilateral disorder which affects the middle and old age group and is characterized by deposition of amyloids which is non-progressive in nature within the corneal stroma mostly in mid to deep corneal stromal layers. The deposits form multiple and filament-like opacities in an axial distribution. The name Amyloid Corneal Degeneration was given by Mannis et al in 1975. The older name, polymorphous stromal dystrophy, was given by Thomsitt and Bron. Due to lack of evidence of heritability the term degeneration instead of a dystrophy was introduced and it is present only in people older than 50 years of age.

Amyloid Corneal Degeneration

EPIDEMIOLOGY

  • Mostly no genetic basis of inheritance.
  • This disease usually manifests after 50 years of age.
  • There is no sexual predominance, i.e. affects both male & females equally.
  • Non progressive disorder i.e. the amyloid deposits don’t progress.
  • Relatively an asymptomatic condition.

SIGNS AND SYMPTOMS

Signs

  • Gray or white opacities which are of distinct shapes mostly filament-like in shapes present in the mid to deep corneal stroma, most commonly in a mid-peripheral annular distribution.
  • No inflammation is seen.
  • Whitish, gelatin-like amyloid deposits are observed in the sub epithelial region giving the corneal surface a multi lobulated appearance which looks similar to mulberry.
  • Corneal changes range from anterior stromal to even sub epithelial vascularization.

Symptoms

  • Normal distant and near vision
  • Sometimes there is slight reduction in visual acuity as much as one line.
  • Loss of vision can be severe when the deposits fuse to cause opacity in the cornea

Diagnosis

  • Clinical: Slit Lamp examination.
  • Histopathology: Eosinophilic deposits in the stroma are stained with Congo red and these are subjected under polarized light and they show a dichromatic nature. They are
    • PAS -negative,
    • With Masson’s trichrome- stain red
  • Confocal microscopy can show lesions within the various layers of cornea including Descemet’s membrane, anterior corneal stroma and deep corneal stroma.

Differential diagnosis

This condition can be confused with these following conditions due to resemblances in the clinical picture:

  • Lattice dystrophy of Cornea Type 1
  • Fleck dystrophy.
  • Schnyder crystalline corneal dystrophy.
  • Granular corneal dystrophy Type 2 (Granular-lattice dystrophy)

Correlation in Ayurveda

As Amyloid corneal degeneration are basically corneal opacities so due to the resemblance in features we can co relate it with avran shukra.

ancient reference correlation acd ayurveda

The quoted Shloka was written by Acharya Susrutha (Ref.-Sushruth Uttaratantra 5/8) and it explains the clinical picture of the Avarna shukra:

Meaning of Shloka: If the corneal part of the eye gets a cloud-like white appearance due conjunctivitis, and doesn’t have much pain or tears. This condition is known as Avarna Shukra.
Prognosis: Good, if the disease’s condition is non-progressive or any kind of difficulty in vision. As Avarna Shukra is located in the deeper layers of the cornea i.e. 2nd and 3rd layers, when it becomes thicker, chronic then it is difficult to treat.

Some conditions/clinical observations given by Acharaya Bhagbhatta for the condition after which the condition of disease becomes asadhya (non-treatable) when: (Ref. Ashtanga Hridaya uttarsthana 10/31)

  • There is loss of vision due to the opacity.(shukra)
  • The opacity starts giving red or black colored appearances.
  • It is very inflamed or too deep.
  • It starts filling with tears or forming sinuses.
  • It becomes older (chronic).

Food items beneficial for this condition

  • Carrots
  • Vitamin A rich fruits & vegetable
  • Smoothie of greens (e.g. Spinach, mint, tulsi leaves grinded in fruit juice as base).
  • Introducing browntop millets in diet plan
  • Use of Amla (Embellia officianlis) and other citrus fruits.
  • Use of legumes.
  • Green leafy vegetables.
  • Use dry nuts after well soaking and peeling off.

TREATMENT

Amyloid Corneal Degeneration usually doesn’t affect the normal visual acuity, but if it does the following are the Ayurvedic principles of treatment as mentioned by Acharyas for Avarna shukra which are to be considered:

Amyloid-Corneal Degeneration treatment

The above-mentioned shloka describes the treatment principles for Avarna Shukra as quoted by Acharaya Bhagbhata. (Ref- Ashtaang Hriday Uttarsthana 11/29)

Meaning of Shloka

  • Triphala can be administered according to doshas, in diseases of shukra in wet/dried form.
  • Use of tikta ghrita.
  • Jaloka Avacharan etc. (leech therapy) procedures for Raktamokshan (blood-letting).
  • Virechan (detoxification procedure),
  • Use of Aaschyotan, putpaka and tarpan etc. (procedures for eyes) procedures.

Planet Ayurveda is a manufacturing unit that makes the Ayurvedic products which are based on herbal preparations as mentioned in our Ayurvedic texts as well as being guided by our experts. The medicines in Planet Ayurveda are basically from natural origin, are duly purified and then the formulations are made with time-tested methods.

Herbal remedies by our experts’ for Amyloid corneal degeneration are

  1. Bilberry Capsules
  2. Angel eye Vitale
  3. Pitta Balance
  4. Vrihat Vatchintamani Ras
  5. Brahmi Chyawanprash
  6. Saptamrit Loh tablets
  7. Jivantyadi Ghrita
  8. Curcumin Capsule

1. Bilberry Capsules

It is a mono herb preparation in capsule form, which contains multiple useful chemical constituents that include flavonoids, anthocyanin pigments and other naturally occurring antioxidants that are very much useful in keeping good eye health. Ingredient- standardized extract of Vaccinium myrtillus.

Dosage: 1-2 capsules one or two times a day.

2. Angel Eye Vitale

It is a compound formulation which contains multi vitamins obtained from natural sources having great results for the patients of eye disorders. Few ingredients include vitamin A, vitamin C, vitamin E, zinc, copper etc. All these elements give well nourishment to the eyes.

Dosage: – 1 capsule twice daily after meals.

3. Pitta balance

It is a multi-herbal preparation. Avarna shukra as mentioned above is caused due to rakta dushti i.e. vitiation of blood so with the help of this medicine the balance is obtained by vitiation of pitta which indirectly calms out vitiation of blood and thus proves to be very helpful in. Ingredients include Praval pishti (Coral compound), Akik pishti (Agate compound), Jahar Mohra Pishti, Kaamdudha Rasa, Mukta Pishti (Pearl compound), Giloy Satava (Tinospora cordifolia).

Dosage: 1 capsule once or twice a day.

4. Vrihat Vatchintamani Ras

It is a poly mineral product made from minerals in tablet form as mentioned in classical texts. Ingredients include Swarna Bhasma, Abhraka Bhasma and Rajata Bhasma etc. It helps to keep the nervous system in a healthy state and hence very much beneficial for the eyes.

Dosage: 1-2 tablets two times a day with water.

5. Brahmi Chayawanprash

It is a classical herbal formulation made from many ingredients in avaleha form, which is very much beneficial for the brain and eyes. Ingredients are Brahmi (Bacopa monnieri) with Dashmoola (roots of 10 herbs) etc.   Brahmi itself is a brain tonic and contains many antioxidants which helps in clearing out various amyloids or other wastes thus making the eyes’ health good.

Dosage:  2-3 teaspoonful, two to three times daily after meals.

6. Saptamrit loh Tablets

It is a herbo-mineral formulation which contains both mineral and herbs. The mineral ingredient here is Loh bhasma (ash of purified iron) which is very much effective in raktaja disorders (blood disorders) & also good in keeping eyes healthy. Also herbal other ingredients are beneficial for the eyes.

Ingredients include Bibhitaki (Terminalia bellerica), Amlaki (Embilia officinalis) etc.

Dosage: 2 to 3 tablets two times a day with Honey or Ghee.

7. Jivantyadi Ghrita

It is a classical poly herbal preparation with multiple ingredients in ghrit form. According to Ayurveda this ghritam can be used for snehana karma which is beneficial for all the Netra rogas. Also it can be used for various netra tarpan. Here in this disease Jivantyadi ghrita is used for vata kapha Ghana properties and for internal/external oleation therapy to get better results.

Dosage:-

    • For internal use: 1 teaspoon with warm water or with food (as the patient feels comfortable).
    • For external use: Quantity sufficient or as directed by the physician.

8. Curcumin Capsules

It is the herbal formulation obtained from a single ingredient, & is available in capsule formulation. It is an extract of Turmeric (Curcuma longa 95% std. extract). Curcumin has a variety of medicinal properties that include antioxidant, anti-inflammatory, antimicrobial properties. Curcumin belongs to a group of natural antioxidants. Curcumin is rich in strong antioxidant agents. It helps in clearing out various forms of free radicals, so in this disease it is very much beneficial in scavenging the extra amyloids that are responsible for the disease formation.

Dosage: – 1-2 capsules twice or thrice a day.

Contact my assistant to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214030 Or Check Website – www.PlanetAyurveda.com

CONCLUSION

As described earlier in this article this is a disease that is mostly non progressive and symptomless but it can lead to very serious manifestations including loss of vision. The diagnosis is based on clinical examination Thus, due to the variety of scopes of treatment methods and herbal based medicines including diet modification, one can consider a better way of having treatment of Amyloid Corneal Degeneration with Ayurveda. For more information kindly visit www.planetayurveda.com

Ayurveda for Rhino-Orbital Mucormycosis Infection

Abstract

This article is about the ayurvedic management and prevention of Rhino-orbital mucormycosis, also known as rhino orbital zygomycosis, is a disease of the nasal-ocular cavity. It is a form of fungal infection affecting cavities of the head. It is caused by the ‘mucorale’ type of fungus, hence the name mucormycosis. It usually affects a person whose immune system is not as strong compared to other healthy individuals. Most commonly reported symptoms are double vision, partial or total loss of vision in one or both eyes, and weakness of the eye muscles. It can lead to permanent blindness and even death. Herbal remedies are provided for its management.

Introduction

Rhino Orbital Mucormycosis is a kind of mucormycosis. Mucormycosis is the name of a fast growing infection caused by a fungus of the family Mucoraceae (order Mucorales). It majorly affects the people whose immunity is compromised i.e. is not able to perform as well as it used to before the person was exposed to certain environmental factors or medication. Depending on the region of the body that it affects, mucormycosis infection is categorized as of the following types:

  • Rhino – cerebral mucormycosis: it involves the nose, the sinuses and the brain. The following are also ultimately recognized as rhino cerebral mucormycosis:
    • Rhino – nasal mucormycosis: it involves only the nasal cavity and the paranasal sinuses (rhino meaning nose, nasal standing for the sinuses).
    • Rhino – orbital mucormycosis: it affects the nose, the paranasal sinuses and the whole eyes (rhino meaning the nose, orbital standing for the hollow cavity of the eye).
    • Rhino – orbito – cerebral mucormycosis: it affects the nose, the sinuses, the eyes and the brain (rhino meaning nose, orbito meaning hollow of the eye, and cerebral standing for the brain).
  • Pulmonary Mucormycosis : when the airways and the lungs are also affected, it is called pulmonary mucormycosis (pulmonary meaning lung related).
  • Cutaneous Mucormycosis : when the fungal spores (cells) enter the body through ruptures in the skin, it is called Cutaneous mucormycosis (Cutaneous meaning skin related).
  • Gastrointestinal Mucormycosis : when the spores manifest in the stomach and then travel to the intestines, it is called gastrointestinal mucormycosis (gastrointestinal stands for stomach and the intestines).
  • Disseminated Mucormycosis : when the fungal; infection spreads in all the blood and through it to the rest of the body, it is called disseminated mucormycosis (disseminated meaning ‘spreading throughout’).

Symptoms of Rhino Orbital Mucormycosis

  • Fever
  • Pain in the eyes
  • Redness in the eyes
  • Swelling in cheeks
  • Loss of sensation in the face
  • Paralysis of the facial muscle
  • Formation of layer of dead cells
  • Damage of the hard palate
  • Lumps in the nasal passage
  • Fluid retention in the eyelids
  • Protrusion of eye muscles
  • Reduced movement of eye muscles
  • Reduced vision in one or both eyes
  • Loss of vision in one or both eyes
  • Eye lenses become opaque
  • Cornea becomes extra curved
  • Unable to focus
  • Inflammation of the sinuses
  • Ulcers inside the mouth
  • Black Ulcers inside the mouth and the nose
  • Totally closed eyes due to extreme swelling and edema in eyelids

Causes

Various factors contribute to the development of any condition in an individual.  In case of mucormycosis, the inhalation of fungus cells is the only cause. Mucormycosis becomes aggravated so fast that its immediate treatment is very important.

  • Fungal cells (called spores) are present everywhere. If these are inhaled, they spread fast into the nasal sinuses and from there affect the brain.

Risk Factors

Some factors decide the severity and susceptibility of a condition affecting a particular individual. Those factors are:

  • Diabetes Mellitus
  • Diabetic ketoacidosis
  • Hypertension
  • Immunosuppressant therapies
  • Tumors
  • Tumor suppressing treatments
  • Chemotherapy
  • Protein deficiency
  • White blood cell deficiency
  • Organ transplantation
  • Bone marrow transplantation
  • HIV AIDS infection
  • Anemia i.e. lack of iron
  • Hemochromatosis i.e. excess of iron
  • Chronic kidney disease

Complications

  • Complete loss of vision
  • Exenteration i.e. Removal of eyes may be required
  • Removal of various glands may be required
  • Nervous failure
  • Total paralysis
  • Death

Herbal Remedies for Rhino-Orbital Mucormycosis Infection
Buy Now

Herbal Remedies By Planet Ayurveda

Planet Ayurveda manufactures pure herbal formulations that are used as medications and tonics worldwide. These formulations are carefully sourced from authentic texts on Ayurveda written in ancient India thousands of years ago. The formulations are chemical free and additive free and thus safe for consumption by people of all ages and individual conditions. The products are suitable for people with all dietary preferences and restrictions since these are completely plant-based, halal and completely organic. A combination has been created by experts at Planet Ayurveda for ayurvedic management of rhino-ocular mucormycosis infection.

Product List

  1. Gandhak Rasayan
  2. Kaishore Guggul
  3. Manjishtha Capsules
  4. Neem Capsules
  5. Pitta Balance

Product Description

1. Gandhak Rasayan

These tablets are made with purified Sulphur which aims at purifying the deepest levels of tissues in the body, thus preventing as well as eliminating the microbial growth in the nose and the eyes.

Dosage : 1-2 tabs thrice daily with lukewarm water after meals.

2. Kaishore Guggul

a formulation of Guggul (Commiphora mukul) with other herbs including Amla (Emblica officinalis), Haritaki (Terminalia chebula), Bibhitaki (Terminalia bellirica), Red physic nut, etc. which aims to prevent spread of microbes through the blood, Kaishore guggul is recommended in mucormycosis because it is an effective antimicrobial too.

Dosage : 2 tabs twice daily with warm water after meals.

3. Manjishtha Capsules

made with the pure extract of Manjishtha (Rubia cordifolia) these capsules will help to purify the skin and blood and hence prevent fungal growth in the cavities of the body.

Dosage : 2 caps twice daily with plain water after meals.

4. Neem Capsules

made with the pure standardized extract of Neem (Azadirachta indica) in the form of capsules, it is known widely for its beneficial properties on the whole body internally as well as externally. It is also an antimicrobial in nature.

Dosage : 2 caps twice daily with plain water after meals.

5. Pitta Balance

a herbo -mineral formulation consisting of Kamdudha Ras (calcium compound), Mukta Pishti (Pearl calcium), Giloy Sattva (Tinospora cordifolia), etc., Pitta Balance capsules are immune boosting and also help promote growth of white blood cells required to fight fungal infections.

Dosage : 1 cap twice daily with plain water after meals.

CONCLUSION

Mucormycosis of the rhino-ocular cavity is affecting many people presently. It may be associated with Covid – 19 and other contemporary microbial infections because the cases have surged especially in the people who are receiving modern treatment of Covid – 19. The medications used in modern treatment are quite strong and can have many side effects. It is recommended that herbal remedies be sought whenever possible. The herbal remedies described here are generally safe for everyone. These are formulated keeping in mind the requirement of their suitability for all individuals. However, pregnant women and people with multiple conditions should consult an ayurvedic physician before beginning any medication.