Category: आयुर्वेदिक चिकित्सा

Best Herbal Alternatives to Mesalamine for Ulcerative Colitis Treatment


Ulcerative colitis is a chronic relapsing inflammatory bowel disease. It is an inflammation of the large intestine specifically in the colon. It causes ulcers and inflammation in the intestines. This disease mostly affects the innermost lining of the intestines. But it can also affect the whole length of the colon. This inflammation produces tiny sores which is called ulcers and spreads upward direction also. This further causes your bowel to move rapidly and empty frequently. Ulcer causes bleeding and discharge of mucus through anal region. It is an autoimmune disorder and affects people of all ages. The most common drug used in the treatment of UC is mesalamine, but this drug has many side effects also. So in this article we are going to discuss mesalamine and its alternative in Ayurveda.


Mesalamine is an Anti-inflammatory drug. It is the active component of sulfasalazine. This drug probably inhibits prostaglandins and leukotriene synthesis. Mesalamine is the official name given to 5-ASA (aminosalicylic acid). 5-ASA is the active moiety in ulcerative colitis, but this drug is not effective orally. So it has been coated with pH sensitive acrylic polymer. This coated formulation delivers 5-ASA to the small intestine and colon.

ulcerative colitis causes


Mesalamine is not absorbed orally until it is coated with acrylic polymer. It is metabolized in the liver and excreted from urine. Its half-life is 0.5-10 hour. The action of this medicine is hampered in the patient who is suffering from renal diseases.


2.4 gm dose has been found in the improvement of the symptoms of ulcerative colitis. Mesacol (Mesalamine) is available in following formulations and doses:

  1. Mesacol 400 mg
  2. Mesacol 800 mg
  3. Mesacol 1.2 grams
  4. Mesacol enema 4 g/60 ml.

Adverse effects

  • Nausea
  • Abdominal pain
  • Headache
  • Fever
  • Fatigue
  • Flatulence
  • Dizziness
  • Acne
  • Nephrotoxicity


It is contraindicated in

  • Hepatic and renal impairment
  • It should not be taken with glucocorticoids and sulfonylureas as it causes gastric toxicity and also increases the hypoglycemic action of sulfonylureas.
  • Also there are interactions with furosemide, spironolactone, methotrexate and rifampicin.


  • Ulcerative colitis
  • Crohn’s disease

The physician advised the patient that he/she had to live on the medicine for lifelong. Only dose adjustment is there either in lower dosage or higher dosage as per the patient symptoms. Long term use of this medicine causes hepatic and renal impairment.

Alternatives in Ayurveda

Ayurveda is the oldest holistic science. It treats various acute and even chronic diseases. This science treats the disease from its root cause. It provides two best formulations which are good alternatives to mesalamine. These two formulations include Kutaj ghan Vati and Vatsakadi Churna. These two herbal formulations have proven better for ulcerative colitis disease. This Ayurvedic medicine is much more effective than mesalamine and doesn’t cause any side effects as mesalamine does.

herbal supplements for ulcerative colitis

herbal supplements for ulcerative colitis1. Kutaj ghan vati

  1. This is a classical Ayurvedic formulation. It is made from the standardized extracts of Kutaj (Holarrhena antidysenterica). This herb is used in treating acute or chronic diarrhea. As the name suggests dysenterica it is mainly used in diarrhea, dysentery. This is the best herbal supplement for ulcerative colitis. Severe forms of diarrhea, dysentery, bleeding can be cured with the regular use of kutaj ghan vati. This provides proper functioning to the intestines. It provides complete relief from the symptoms of inflammatory bowel disease.

Chemical composition

Seeds of kutaj contain five main alkaloids

  • Conessine
  • Isoconessimine
  • Conessimin
  • Conarrhimin
  • Conimin

These alkaloids have antidysenteric and anthelmintic properties

Ayurvedic properties of Kutaj (Raspanchak)1

1. Ras (taste) – tikta (Bitter), kshaya (Astringent)

These two tastes help in pacifying pitta dosha and helps in stoppage of bleeding from stools.

2. Guna (properties) – Laghu (light), Ruksha (dry)

These properties help in balancing the vata dosha and stop the spread of this disease. This herb is easy to digest

3. Virya (potency) – Sheet (Cold)

This cool potency is helpful in ulcers and bleeding condition

4. Vipaka (post digestion effect) – katu (Pungent)

This pungent property helps in digestion and provides anti-inflammatory action

5. Karma (uses)

Piles, diarrhea, dysentery, mucus, skin disorders

2. Vatsakadi Churna

This is an Ayurvedic classical formulation. It provides strength to the digestive system naturally. It contains Kutaj (Holarrhena antidysenterica) and Bilva (Aegle marmelos). These two herbs are very beneficial in digestive disorders. This formulation is best to check diarrhea, gas formation and irregular bowel movements.

This formulation is used in treating mucus formation

1. Ras (taste) – tikta (Bitter), kshaya (Astringent)

Helps in stoppage of bleeding from stools and mucus.

2. Guna (properties) – Laghu (light), Ruksha (dry)

It is easily to digest and treat ulcers

3. Virya (potency) – ushna (hot)

It is helpful in improving digestion

4. Vipaka (post digestion effect) – katu (Pungent)

It improves digestion and stimulates digestive fire

5. Karma (uses)

Piles, diarrhea, dysentery, mucus


As mentioned above in the article mesalamine is having many side effects that leave very serious impacts on the body especially on our immune system. Our immune system is responsible for protecting our body from various kinds of infection and disorders and any impairment in our immune system can lead a person towards drastic conditions. So it’s better to use Ayurveda treatment because it does not cause any side effects and also treats the disease from its root. So above mentioned two best herbal formulations are effective in inflammatory bowel disease.


  1. Bhavprakash nighantu, Guduchyadi varga/118

How to Balance your Health through Ayurveda


Ayurveda literally means the science or the knowledge of life. But, in practical terms, it has a meaning much beyond words. It is the glory of Ayurveda that an ancient science that flourished over thousands of years ago still holds a crucial part in governing the health of even the most modern generations. Ayurveda gives primary importance to diet, lifestyle, moral values etc along with natural medicines. More than being a health-care system, it shows us a way of life and urges to follow a middle path by avoiding the extremes. The core of Ayurveda emphasizes a customised approach due to the unique constitution of each individual. However, the fundamental rules for a healthy life are mentioned in general to be followed by everyone. Acharya Susrutha holds the view that you are considered to be healthy if the doshas (vata, pitta and kapha), agni (digestive fire), dhatus (tissues) and malas (waste products) are in the balanced state along with spiritual, mental and sensory well-being. So, to keep these in order, we need to follow a certain age-appropriate food regimen and routine daily and seasonally. Let us go for some general rules to balance our health.

For healthy living, food and water have to be taken only when hunger and thirst strike. That is, listen to nature’s call. Frequent eating habits are not at all to be encouraged. It hampers the digestive process and eventually leads to diseases. A minimum of 3 hours and maximum of 6 hours is necessary to be kept in between the meals for proper balance. Digestive fire (Agni) is given utmost importance in Ayurveda and once it is on the right track, rest everything gets corrected automatically. Each one of us would be possessing a different range of digesting capacity and should learn to eat and drink accordingly. For that, the golden rule of “50% solid, 25% liquid and 25% empty space” has to be followed during the meal times. Moreover, eatables should be chewed well before swallowing which initiates proper digestion from the mouth itself. For a well- balanced diet, all tastes should be included regularly, as single taste usage disturbs the dosha balance in the long run. As per Ayurveda, the order of consumption of tastes in a particular meal should be in the order of sweet, sour, salt, bitter and astringent successively. This helps in stabilizing the Doshas and easing the digestion. Moreover, seasonal variations have also been explained in terms of taste predominance, say, for example, excess salt, sour and pungent tastes should be avoided in summer and intake of sweet taste should predominate. Similarly, season-specific changes should be made in the diet.

Food items like red rice, green gram, pomegranate, raisins, rock salt, cow ghee, ginger etc can be used regularly in the right amount whereas black gram, mustard, curd, beef etc are not meant for regular use. A list of incompatible food items (Viruddhahara) has been mentioned clearly by various scholars whose regular intake may act as a slow poison and destroy their health gradually. Some among them are milk and jaggery, milk and fruits, chicken and curd, plantain and buttermilk, wheat preparations in sesame oil etc.

There are so many misconceptions revolving around drinking water while having food. The fact is, Ayurveda advises obese people to drink some water before food and for lean persons, it is suggested after food. Although, little amount of water, buttermilk or rice gruel can also be taken along with food for aiding proper digestion.

Apart from these, filling the tummies just before taking bath hinders the digestion which in turn affects the body balance. Hence, better to enjoy the food after the shower, with a calm mind leaving behind all hurry buries.


Talking about sleep habits, even though ‘brahma muhurtha’ (one and a half hours before sunrise) is suggested to be the best time to wake up, it would be beneficial to be awake at least by sunrise or as early as possible. This routine upgrades the health of healthy people and is for those who sleep on time (by around 9 or 10 pm), as 7-8 hours of sleep is mandatory. Those people can deviate from this, who are debilitated from any disease or who need to be awake at night (though not advisable). For them, day-sleep is advocated for almost half the duration of deprived sleep at night. Except for those exhausted from illness, extremely tired, old-age people and children, day-sleep has been contraindicated for all others as it may result in obesity and diseases due to over-nourishment.

Don’t ever think that following the rules of food is enough for health. Any kind of physical activity or exercise should be executed according to one’s strength. Since over-exercise and no exercise are equally harmful, following a mild exercise would be adequate for proper blood circulation and maintaining the equilibrium.

Further to this, Ayurveda mentions about the suppressible and non – suppressible urges whose violation leads to disturbances in body functions. Urges of flatus, urine, stools, sneeze, thirst, yawning, hunger, sleep, cough, panting, tears, vomit and semen should never be suppressed. Similarly, forceful action of un-manifested urges too results in diseases. Meanwhile, it directs us to overcome the urges of anger, ego, greed, fear, grief, jealousy, over-exertion, violence, stealing, speaking harsh words, lying etc for physical as well as mental well being.

Different varieties of herbs can be made use in our day-to-day life for supporting our health. Twigs from Nimba (Azadirachta indica), Khadira (Acacia catechu), Madhuka (Glycyrriza globra) and Karanja (Pongamia pinnata) can be used for brushing the teeth which should be changed after every use. It helps in pacifying the kapha dosha and clears the mouth. Similarly, Gandusha and Kavala can be done with suitable liquids like milk, honey, water, rice gruel etc which gives nourishment and strength to the facial muscles and teeth. It also enhances taste, prevents throat dryness and cracking of lips. Herbs like Tulsi (Ocimum sanctum), Khadira (Acacia catechu), cumin (Cuminum cyminum), ginger (Zingiber officinale), Ela (Elettaria cardomomum), coriander etc can be used wisely, according to seasons and diseases, in boiling water for drinking.

Ayurveda is a treasure trove of many such preventive as well as curative remedies that need to be followed by each and every one of us. From that ocean of knowledge, some simple yet effective rules and techniques have been covered here, in order to live in balance.