Category: Essential Thrombocythemia

Ayurvedic Perspective of Glanzmann Thrombasthenia – Platelet Disorders

ABSTRACT

Glanzmann Thrombasthenia is a bleeding syndrome type of rare autosomal recessive and characterised by platelet aggregation. GT is associated with clinical variability: some of them mild bruising but sometimes it occurred large blood vessels haemorrhage. Haematuria and gastrointestinal bleeding are less common but some of the characteristic sites of the bleeding are purpura, epistasis, gingival haemorrhage etc. In most cases, bleeding symptoms present afterlife but GT is diagnosed in later life. In the modern system of medicine full cure for treating this disease is not available; they, at last, transfuse platelets when no other option is left. This is not the proper way to treat any disease because after some time the platelets count decreased again. Ayurveda has many herbs indicating bleeding disorders that will definitely increase platelet count in a restorative way.

INTRODUCTION

Platelets are a very important component in stopping any kind of bleeding as in the case of hemostasis. In Hemostasis damaged sub endothelium releases adhesive proteins and fibrinogen which are attached to the site of injury with platelets and form a platelet plug. Platelets provide a surface for the attachment of coagulation factors. Then this will activate platelets to form a thrombus. Any kind of defect in this mechanism or process can cause bleeding disorders.

Glanzmann first described this in the year 1918 and called it “hereditary hemorrhagic thrombasthenia”. Its main characteristic features for diagnosis are prolonged bleeding time, clumped platelets and the appearance of platelets on a peripheral blood smear.

GLANZMANN THROMBASTHENIA

DIFFERENTIAL DIAGNOSIS

Platelet aggregation defects which are mainly due to adenosine diphosphate (ADP) or collagen can mimic Glanzmann thrombasthenia.  But GT has one specific feature of clot retraction. It is also sometimes misdiagnosed as Bernard- souler syndrome and vonwillebrand disease due to the involvement of platelet aggregation in both

AETIOLOGY

Megakaryocytes are present in the bone marrow and on maturity, they liberate large no. of platelets into the blood. In GT platelets can’t be aggregated in response to natural agonists while they are present in their normal shape. The genes which are defected in this disease are present on chromosome 17 of DNA. This is an autosomal recessive condition which means it occurs only if both parents are having this disease

SYMPTOMS OF GLANZMANN DISEASE

  1. Nose bleeding(Epistasis)
  2. Bruising easily
  3. Bleeding gums
  4. Heavy menstrual bleeding
  5. Bleeding during or after surgery
  6. Mucocutaneous bleeding

DIAGNOSIS

The clinical manifestation of some diseases is the same sometimes as in the case of  GT and other cases of platelet aggregation. The main diagnostic test for GT are:

  1. Normal platelet count
  2. Bleeding time
  3. Light transmission aggregometry
  4. Platelet function analyser
  5. Flow cytometry
  6. Mutation analysis

AYURVEDIC VIEW

In Ayurveda the body depends on anna(food) and other four factors namely vat, pitta, kapha and rakta . The rakta is considered to be the most important in it because any type of injury internal or external or any coagulation disorder leads to morbidity or mortality. This Glanzman thrombasthenia can be correlated with the rakta pitta it is said to be mahavega or mahagada by acharya charak mentioned in the classical medicinal textbooks of Ayurveda. In this disorder vitiation of pitta is the main cause of the disorder. Pitta is also called lohit pitta because it comes into touch with blood and can cause disease in the blood.

The treatment of bleeding disorder in Ayurveda can be done by shudha dravya varga which is highly composed of calcium carbonate, calcium sulphate, calcium fluoride etc. calcium helps in the coagulation of bleed; it is the important factor in the stoppage of blood. Thus shudha vargiya dravya helps in the coagulation of blood and pacifies the pitta and rakta dushti. Many kinds of animal origin, herbal origin and mineral origin are mentioned in Ayurveda for use as calcium supplements and help in raktapitta chikitsa.

Some of the shuddha vargiya dravya are as follows: Muktashukti(pearl), Shudha(lime), Godanti(gypsum) and pravala(coral) etc. All these are calcium compounds and are helpful in treating many diseases.

HERBAL REMEDIES BY PLANET AYURVEDA FOR TREATING GLANZMANN THROMBASTHENIA

Planet Ayurveda provides one of the most trusted herbal products and formulations for better treatment of diseases. The positive point of using these drugs is that they have no side effects and they are also Iso-certified herbal products which means these products are tested in the laboratory under various high technologies so that they can be trusted. Planet Ayurveda products do not contain any additives, flavours or preservatives which makes them more trustworthy.

Herbal Remedies for Glanzmanns Thrombasthenia

1. IMMUNE BOOSTER

It consists of many useful ingredients i.e it is used in treating Glanzmann thrombasthenia the main ingredients in it are Grape seed(Vitis vinifera std. ext.), Go-Piyush(Bovine colostrums std. ext.), Bhumi amla(Phyllanthus niruri std. ext.) and Amalaki(Emblica officinalis). In bleeding disorders like Glanzman thrombasthenia in this patient’s immunity is very weak and in this condition, if any other disease occurs it may be the worst condition for the patient. For protecting against any other disease and fighting with this disease.

Dosage: 2 capsules should be taken twice daily after meals

2. GILOY GHAN VATI

Guduchi(Tinospora cordifolia )has many beneficial properties in it which can be helpful in treating autoimmune diseases. It is also helpful in treating diseases like fever, diabetes, anaemia and jaundice etc. it is best to know treating raktapitta due to its rasa (taste) kashaya (astringent) is helpful in stopping the blood. It is also known to be balya(improves strength), dahahara (relieves burning sensation), vayasthapana (anti ageing) etc.

Dosage: 2 tablets should be taken daily two times

3. KUMAR KALYAN RAS

Its main ingredients are Ras sindura (formulation of pure mercury), Shudhha Mukta bhasma (purified pearl), Shuddha Swarna bhasma(purified gold) and Shuddha Loh bhasma (purified iron)etc. As discussed above ayurvedic medicine also mentioned the herbs made up through mineral sources also benefitting in many diseases like bleeding disorders, digestive disorders, cold and cough also they provide immune boosting through their actions.

Dosage: 1 tablet to be chewed daily two times

4. SUVARNA BASANT MALTI RAS

The main ingredients of this formulation are Swarna bhasma (purified gold), Mukta bhasma (pure pearl), Maricha (Piper nigrum) and Gandhak (pure sulphur)etc. This contains zinc and from research, it is stated that it can be helpful in the formation of RBC i.e the reason it can be used in the patient of Raktapitta. This formulation can be given in treating diseases like fever, cold and cough, asthma etc.

Dosage: 1 tablet to be chewed daily after meals two times

5. GREEN ESSENTIALS

It is given to patients for increasing immunity. It has many useful ingredients in it like Grape seed (Vitis Vinifera), Wheatgrass (Triticulum Aestivum), and Spirulina (Spirulina Platensis), Green tea (Camellia Sinensis) and Amla (Embllica Officinalis). The green herbs contain chlorophyll which plays a critical role in increasing the blood oxygen as we know the brain and every tissue works properly if oxygen is sufficiently present.

Dosage: One capsule should be given to the patient twice daily after meals

6. PUNARNAVA MANDUR

This formulation is made up of some beneficial ingredients some of them are listed: Punarnava (Boerhaavia diffusa ), Shunti (Zingiber officinale), Pipali (Piper longum) and Chavya (Piper chaba) etc. It is a very effective iron supplement which is mentioned in Ayurveda Samhitas. The principal ingredient is punarnava which is very effective as an anti-inflammatory, blood purifier and hematinic activities(an agent that tends to increase the production of red cell formation so that increases haemoglobin)

Dosage: 2 tablets twice daily after meals

7. SPIRULINA CAPSULES

Spirulina (Spirulina platensis) capsules are highly recommended sources to increase vitamins, minerals and ions. It is a very wonderful herb for maintaining good health. Spirulina is very rich in specific proteins which are superior to other forms of proteins obtained from plants. It contains essential 22 amino acids which even some legumes are not able to provide. Spirulina therapeutic indications: allergic conditions, cholesterol level maintenance, anti-inflammatory properties and antioxidant properties etc.

Dosage: 2 capsules twice daily after meals

Contact my assistant to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214040 Or Check Website – www.PlanetAyurveda.com

CONCLUSION

In the present era, we will know about many diseases which can not be treated by allopathic medicine and that are not well described in them. In the modern system of medicine whenever they do not find any particular symptoms or particular diagnostic features they get confused.  On another side, ayurvedic medicine is recognised with great results in these diseases. Ayurvedic medicine is nowadays present with evidence-based approaches that are scientifically proven. In Ayurveda, most of the diseases occur due to variations of Vata, pitta and Kapha which are called Doshas. In this disease pitta dosha is imbalanced and to maintain it different herbs can be used which are mentioned in the medicinal textbooks of Ayurveda and they are able to treat well.

How to Treat Essential Thrombocythemia in Ayurveda

ABSTRACT

Essential Tthrombocythemia is a rare disorder which is characterized by production of too many platelets. As platelets are the blood cells responsible for the formation of blood clots, hence too many platelets increase the risk of abnormal clotting of blood. Person suffering from essential thrombocythemia experiences fatigue, headaches, lightheadedness, and changes in vision. People above the age of 60 years are more prone to it and women get it more than men. This disorder is considered to be incurable, however there are certain herbal remedies offered by Planet Ayurveda which can help in management of the disease naturally.

INTRODUCTION

Essential Thrombocythemia is an uncommon, chronic and non reactive myeloproliferative disorder which results in proliferation of sustained megakaryocytes leading to abnormal increase in platelets in the circulatory system of the body. The good thing in this disorder is that the life expectancy of the patient suffering from Essential thrombocythemia is just as normal as any other person.

Platelets are one of the blood cells which are necessary for the body in order to clot blood in condition of injury or wherever required. The other two types of blood cells are white blood cells which help the body to fight against various diseases and infections while the red blood cells help in transfer of oxygen to all the parts of the body. Generally both the other blood cells are normal in number. However it is necessary to evaluate the reason for increased platelet count as there can be other reasons as well like infection, iron deficiency or generalized inflammation in the body.

Essential thrombocythemia

SIGNS AND SYMPTOMS

In mild forms of disease there are usually no noticeable signs and symptoms. However as the disorder progresses patient starts to develop certain signs and symptoms (due to the formation of clot in different parts of the body like, feet, hand or brain)

  • Lightheadedness or dizziness
  • Headache
  • Pain in chest
  • Vertigo and fainting
  • Temporary changes in vision
  • Tingling or numbness sensation in feet and hands
  • Redness of feet and hands
  • Burning and throbbing pain in hands and feet
  • Bruising
  • Nosebleed
  • Blood in stool
  • Bleeding gums or from mouth
  • Ringing in ears

CAUSES

Essential thrombocythemia is known as a type of chronic myeloproliferative disorder because in this the spongy tissue inside the bones, i.e. bone marrow produces abnormally too many certain types of cells like platelets. The exact cause behind this is not known, however in most of the cases there is reported mutation of certain gene causing Essential thrombocythemia to develop. There is also a secondary thrombocytosis in which the platelet count becomes high due to other underlying conditions like iron deficiency. However the risk of blood clots and bleeding is less in secondary thrombocytosis as compared to the essential thrombocythemia.

DIAGNOSIS

Initially on reporting to the doctor for the certain signs and symptoms mentioned, the basic blood tests will be suggested that will reveal the high platelet count. To confirm the diagnosis of Essential thrombocythemia, the doctor needs to rule out all other causes of high platelet count. During this the blood tests are done to check number and size of platelet counts, iron level, markers of inflammation and genetic testing to find out the flaws in JAK2, MPL or CALR genes.

TREATMENT

As the essential thrombocythemia is considered to be an incurable disorder, hence the treatment is aimed at controlling the signs and symptoms of the disease and prevents the complications. Conventionally various medicines are prescribed like Hydroxyurea, Anagrelide etc. But both the drugs have many side effects when given for long term use.

Ayurveda can here be a helping hand, as the herbs and herbal remedies used in this system of medicine do not cause any side effects along with managing the presenting complaints and preventing complications. This is so because these herbs possess natural therapeutic properties which annihilate the disease and its accompanying signs and symptoms.

Other than herbal remedies there are two therapeutic methods in Ayurveda which can help in management of essential thrombocythemia, i.e. Virechan and Rakt moshan.

1. Virechan

It is a Sanskrit word which literally means purging or laxative that refers to a particular substance which causes purging. It is an Ayurvedic procedure which is used to eliminate the accumulated toxins in the body. Similarly it helps in elimination of excessive platelets from the body bringing the count back to normal.

2. Raktamokshana

It is a blood purifying and cleansing Ayurvedic method which is therapeutic in nature. It is one of the five purification procedures used in Ayurveda. In this the vitiated blood is let out from the body. In this leech therapy is considered to be convenient and easy to execute the technique. Leeches (6- poisonous and 6- non poisonous) are planted on the body after clearing the area with antiseptic. They fall off themselves after completing the blood sucking of vitiated blood. Then turmeric is rubbed on this area to stop bleeding from the leech bitten site.

HERBAL REMEDIES for Essential Thrombocythemia BY PLANET AYURVEDA

Planet Ayurveda is a well recognized herbal pharmaceutical brand and company which deals with the production of herbal products and medicines that are further prescribed to the patients by expert Ayurveda doctors to treat and manage the disease. Owing to the fact that there are no chemicals, preservatives, additives, dye, binders, colors, fillers or yeast in these products, the efficacy and safety rises up more. All the formulations are prepared using classical references from Ayurveda texts and under the strict supervision of MD Ayurveda doctors. For Essential thrombocythemia Planet Ayurveda offers a combination of herbal remedies that can help in management of the disorder.

Products List

  1. Arogyavardhini vati
  2. Kaishore guggul

Herbal-Supplements-for-Essential-Thrombosis

Herbal-Supplements-for-Essential-Thrombosis

Products Description

1. Arogyavardhini Vati

Herbs like Haritaki (Terminalia chebula), Shilajit (Asphaltum), Bibhitaki (Terminalia bellerica), Amalaki (Emblica officinalis), Katuki (Picrorhiza kurroa), and mineral compounds like Shuddha parade (Purified mercury), Shuddha gandhaka (Purified sulphur), etc. Arogyavardhini vati helps in balancing all three doshas and hence preventing the development of the disease and its eradication. It also possesses anti inflammatory, anti viral, anti bacterial etc properties.

Dosage– Take 2 tablets twice daily after meals with plain water

2. Kaishore Guggul

It is the herbal combination of Amalaki (Emblica officinalis), Haritaki (Terminalia chebula), Bibhitaki (Terminalia bellerica), Giloy (Tinospora cordifolia), Shunthi (Zingiber officinale), Maricha (Piper nirgum), Pippali (Piper longum) etc. Kaishore guggul helps in clearing the toxins from the blood and boosts immunity. It helps in treating various inflammatory disorders and diseases caused due to high Pitta in the body.

Dosage– Take 2 tablets twice daily after meals with plain water

Contact Planet Ayurveda to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214040 Or Check Website – www.PlanetAyurveda.com

CONCLUSION

Essential thrombocythemia is an uncommon disorder which is caused due to abnormal mutation in certain genes. In this platelet count grows too high than the normal causing signs and symptoms and complications. Herbal remedies mentioned here can help in management of the condition without causing any harm to the body even if taken for long term.