Giant lymph node Hyperplasia is a group of rare lymphoproliferative disorders characterized by swollen lymph nodes, microscopic features of enlarged lymph node tissue. The article is devoted to a give you information on Giant Lymph node Hyperplasia or Castleman’s disease, its concepts, classification, and treatment.
What is Giant lymph Node Hyperplasia
Giant lymph node Hyperplasia is also known as Castleman’s Disease or angiofollicular hyperplasia. Castleman’s disease is named after Dr. Benjamin Castleman, who first described this Giant Lymph node Hyperplasia (Castleman’s disease) disease in 1956. It is a rare disease in which there is an excessive proliferation of lymphoid tissue due to the division of its cells (proliferation) – lymphocytes, which normally fight various diseases. It has localized (unicentric) or widespread (multicentric) flow variants.
Types of Giant lymph Node Hyperplasia
The subtypes of Giant lymph node hyperplasia reflect the number of lymph nodes in regions with enlarged lymph nodes and known causes of the disease. In unicentric disease, one or more enlarged lymph nodes are present in one area of the lymph nodes. In multicenter disease, enlarged lymph nodes are present in several areas of the lymph nodes. The only known cause of Castleman’s disease is an uncontrolled infection of human herpes 8, which has only been reported in cases of the multicentric disease.
There are Three Established Subtypes of Castleman’s Disease.
- Unicentric or Local Giant Lymph Node Hyperplasia
- Multicentric or Widespread Giant Lymph Node Hyperplasia
1. Unicentric Giant Lymph Node Hyperplasia
In Unicentric Giant Lymph Node, one or more enlarged lymph nodes are present in one area of the lymph nodes. It is one of the common subtypes of Giant lymph node Hyperplasia disease and, its symptoms tend to be milder, organ dysfunction is rare, and surgical removal of enlarged lymph nodes is the treatment of choice.
2. Multicentric Giant Lymph Node Hyperplasia
In Multicentric giant Lymph node, the enlarged lymph nodes are present in various region of the lymph nodes and are not known. It is less common than a unicentric Giant Lymph Node. Its symptoms tend to be more severe than Unicentric Giant Lymph Node Hyperplasia.
Causes of Giant Lymph Node Hyperplasia
It is not yet clear what causes Giant lymph node hyperplasia. It is known that infection with the herpes simplex virus type 8 is associated with a multicentric variant of the disease.
The exact role of HHV-8 in disease progression remains unclear. It enhances the proliferation (division) of the affected cells of the immune system. The cells of the immune system produce a protein called interleukin-6 (IL-6), which contributes to the proliferation of lymphatic cells.
Human Herpes Virus 8 type (HHV-8) is also associated with the development of Kaposi’s sarcoma, a malignant tumor of the walls of blood vessels that can be a complication of HIV / AIDS.
Symptoms of Giant Lymph Node Hyperplasia
Castleman’s Disease is one of the rare problems that individuals face. Giant Lymph Node Hyperplasia symptoms differ from person to person. It is an enlargement of lymph nodes that are present in various regions of the lymph nodes and infection with human herpesvirus 8 is present. Some of the symptoms which can be felt as a result of Giant lymph node hyperplasia can be:-
Symptoms of Unicentric Giant Lymph Node Hyperplasia
Many people with unicentric Giant Lymph Node Hyperplasia have no symptoms. Lymph nodes in the chest, abdomen, and neck are most commonly affected. When symptoms appear, they include:
- Feeling of heaviness or pressure in your chest or abdomen, causing trouble breathing or eating.
- Swollen lymph nodes (usually one) in the neck, groin, or armpits.
- Unexplained weight loss.
- Less commonly, fever, excessive sweating at night, and weakness.
Symptoms of Multicentric Giant Lymph Node Hyperplasia\
Most people with Multicentric Giant lymph node Hyperplasia disease experience the following symptoms:
- Increased sweating at night.
- Weakness and increased fatigue.
- Loss of appetite.
- Unexplained weight loss.
- Swollen lymph nodes, usually in the neck, collarbone, axillary and groin areas.
- Enlarged liver or spleen.
Other less common symptoms include:
- Damage to the nerve trunks of the upper and lower extremities, which leads to impaired sensitivity (peripheral neuropathy).
- Skin rash.
Complications of Giant Lymph Node Hyperplasia
The multicentric variant of Giant Lymph Node hyperplasia disease can lead to the development of life-threatening complications, such as:
- Infectious complications leading to the development of multiple organ failure.
- Cancers such as lymphomas or Kaposi’s sarcoma.
- The prognosis for multicentric Castleman disease is determined by the nature of the course of the disease. The presence of HIV / AIDS worsens the prognosis.
Diagnostics of Giant Lymph Node Disease
If you notice an enlarged lymph node in the neck, collarbone, armpit, or groin, see your doctor. It is also worth doing this if you have a persistent feeling of heaviness in your chest or abdomen, fever, fatigue, or unexplained weight loss.
- Blood and urine tests.
- CT scan/MRI.
- Positron emission tomography (PET).
- Lymph node biopsy.
Ayurveda And Giant lymph Node Hyperplasia
The Ayurveda medical system (life science) is the traditional system of Indian Vedic medicine, in which holistic principles are practiced, focused on maintaining the health and active longevity of each individual. This ancient Indian doctrine of health and longevity is now popular in many countries of the world and in 1985 was recognized by WHO as the most effective system of oriental medicine.
Long before the deciphering of the human genome, the Ayurvedic physician relied on a constitutional approach to establish the root cause of the disease. The constitution (original nature) can be considered as a generalized morphofunctional characteristic of an individual, which reflects the characteristics of the physique, mental activity, metabolism, and functioning of autonomic systems, adaptive, compensatory, and pathological reactions of a person.
The individual constitution of a person consists of doshas or humor – Vata, Pitta, and Kapha. Translated from Sanskrit, dosha is “that which is out of balance.” Most likely, dosha is a unity of energy, information, and matter, which determines a special psychotype of a person, his individual homeostasis, metabolism, an individual “life route”. Doshas are the qualities that make up our body and personality, the different ratio of doshas in each person determines his uniqueness, individuality. However, all three doshas in different proportions are present in every person. And this unites us. The balance of three energies- Vata, pitta, Kapha leads to disease Free State, according to Ayurveda. So we have prepared a perfect blend of herbs that synergistically helps to control the balance of theses Doshas.
Planet Ayurveda serves best-endowed herbal remedies for treating Giant lymph node Hyperplasia disease. These herbal remedies prepared in Planet Ayurveda contain the best quality herbs and strictly prepared by following the principles of Ayurveda. These Herbal Remedies of Planet Ayurveda are 100% pure, natural, and vegetarian. All medicines are free from any chemicals, additives, and yeast. These herbal remedies are devoid of any kind of side effects. These remedies are safe to use at any age.
These effective Capsules are the perfect blend of Shallaki(Boswellia serrata) and Curcumin (Haridra) (curcuma longa). These herbs are anti-inflammatory herbs and help in prompting circulation in joining. It is a beneficial supplement for providing relief from cartilage pain as it does not get much blood flow.
Dosage: – 1 capsules twice daily, with plain water, after meals.
2. Kachnaar Guggul
Kachnaar Guggul tablets are prepared by using some beneficial herbs that can manage a different health problem. The major ingredients of these tablets include Kachnaar (Bauhinia variegata), Guggul raisin (Commiphora wightii), Amalaki (Phyllanthus emblica). These tablets are helpful in treating tumors or Cancer, manage obesity, treat polycystic kidney disease, cure fistula, manage liver cysts, treat a various skin problems, and manage Hypothyroidism.
Dosage– 2 tablets, twice a day, with normal water, after Meal.
3. Tulsi Capsules
These capsules are prepared by using the pure extract of Tulsi (Ocimum sanctum) herb. It has anti-microbial properties. Tulsi Capsules are helpful in many serious problems like Auto-immune Disorder, Cancer, Skin Allergies, Chronic Sinusitis. Disciplined use of these capsules will help the body to fight against various infectious diseases in effective ways.
Dosage– 1-2 capsules, twice daily, with plain water, after Meal.
4. Immune Booster Capsules
It is a natural supplement for maintaining the overall health of the human body. It is an excellent formulation that is very useful for managing various health ailments. The main components of these capsules are Grapeseed (Vitis vinifera), Cow colostrum (bovine colostrum), Bhumi amla (Phyllanthus niruri), Amalaki (Phyllanthus emblica). These herbs help in strengthening and building immunity that guards our body against various diseases.
Dosage– 2 capsules, twice daily, with plain water, after Meal.
5. Giloy Capsules
Giloy Capsules are formulated by using a standardized extract of Giloy herb (Tinospora cordifolia). This wondrous giloy herb has been used in Ayurveda since ancient times. It helps in fighting the body against infection and building up a strong immune system. Giloy capsules are beneficial in managing weakness, swine flu, urinary tract infections. It effectively helps in increasing blood platelet count.
Dosage– 1-2 capsules, twice daily, with plain water, after Meal.
From the above article, we came to know that Giant lymph node hyperplasia is an enlargement of lymph node in the body. It is one of the rare diseases that may happen to anyone. However, before panic begins to rise, it is important to understand the different ways to maintain our well-being on our own with the help of simple changes in lifestyle and diet, guided by knowledge about our type of constitution (Dosha) and its inherent advantages or weaker features. Planet Ayurveda Herbal medicines will help you in the Treatment of Giant lymph node Hyperplasia by balancing doshas of the human body.