Severe Combined Immunodeficiency (SCID) Treatment in Ayurveda

Abstract

Severe combined immunodeficiency is a rare genetic disorder due to disturbed functional development of B cells and T cells caused by genetic mutations that leads to alteration in clinical presentation. It is also known as bubble boy disease or bubble baby disease and swiss-type agammaglobulinemia. Severe combined immunodeficiency is a fatal condition without gene therapy or transplant of stem cells. There are approximately 13 kinds of genetic defects that may lead to SCID. These defects further cause extreme prone to serious infections. Infants with 80% SCID have no family-related history of this disease. So, today we will read about severe combined immunodeficiency in brief in this article.

Introduction

It is a rare condition caused by genetic mutations that leads to alteration in function and development of immune cells. Newborns with severe combined immunodeficiency look healthy at the time of birth but are extremely susceptible to serious infections. This is a fatal condition until or unless newborns receive treatment for immune restoration like gene therapy, enzyme therapy, or hematopoietic stem cells.

Cause

Severe combined immunodeficiency caused by

• Genetic mutations
• Adenosine deaminase deficiency
• Purine nucleoside phosphorylase deficiency
• Reticular dysgenesis
• Omenn syndrome
• Bare lymphocyte syndrome
• CD3 chains deficiency
• Janus Kinase 3 deficiency

Symptoms

• Recurrent infections
• Weakness
• Rashes
• Delayed growth
• Difficulty in weight gain
• Diarrhea
• Pneumonia
• Respiratory infections
• Failure to thrive
• Oral thrush
• Sinus infections
• Ear infections

Diagnosis

• A full blood lymphocyte count
• DNA test for genetic mutation
• Newborn screening test

Treatment

• Bone marrow transplant
• Chemotherapy
• Gene therapy

Prevention

You can decrease the risk of infection to your baby by

• Avoiding public places
• Prevent baby from infection or cold
• Limiting visitors
• Wash the hands properly before touching the infant.

Ayurvedic overview

In Ayurveda, we can correlate this disease with anuvanshik vyadhi (inherited disease) and other is oja kshaya (immune deficiency). Anuvanshik vyadhi is developed in a person by birth due to deformity in beej dosha (sperm and ovum deformity). Oja means resistance to diseases or immunity against diseases is of two kinds: one which attenuates the manifested disease and other variety prevents the manifestation of diseases. Factors which contributes for oja (immunity) are normal doshas (vata, pitta and kapha), equilibrium state of dhatu, normal agni, patency of srotas etc are the factors which supports the equilibrium state of all physiological parameters. Ojas is the essence of rasadhi dhatus and it is also called bala (strength).

Ojas Kshaya Etiological Factors

According to S.Su 15/23 sholaka

Ojas undergoes decrease due to injury, Tissue depletion, anger, grief, worry, exertion, hunger etc are resulting into the flowing out from the dhatus and getting associated with tejas and instigated by vata, which gives various discomfort to the body.

Clinical Features of Oja Kshaya

मूर्छा मांस क्षयो मोह: प्रलापो मरण मिति च क्षये। (S. Su 15/24)

According to the above mentioned shloka

• Fainting
• Wasting of muscles
• Unconsciousness
• Delirium
• Death

Oja kshaya and anuvanshik vyadhi is an incurable entity because it produces due to improper understanding. We can only give supportive treatment of herbal medicines to inhibit the progression of the disease.

Herbal remedies for SCID by planet ayurveda

Planet Ayurveda is a manufacturing unit of different kinds of ayurvedic medicines for various kinds of diseases which shows effective results in the human body. They strictly follow all the principles of ayurveda which are described in ancient textbooks of ayurveda. All these herbal medicines are GMP certified and pure vegetarian. These are safe to use for the human body. There are no additives, preservatives, chemicals, yeast etc.

In this disease, no specific treatment is available till now. Only supportive treatment will be given which can delay the progression of the disease and provide some immunity to fight against other infections. The planet ayurveda provides herbal remedies for severe combined immunodeficiency which are following

Product List

1. Telomere Boostup
2. Immune Booster
3. Amalaki Rasayan
4. Ashwagandha Capsules
5. Shilajit Capsules
6. Gandhak Rasayan

Product Description

1. Telomere Boostup

It is a polyherbal capsule containing grape seed (vitis vinifera), amalaki (Emblica officinalis), ashwagandha (withania somnifera), etc. It is sweet, astringent, and bitter in taste. It is light, dry and hot in effect. It contains alkaloids, glycosides, flavonoids, amarin, gernanin, etc. It has a tonic effect on the brain and the nervous system. It acts as an anti-inflammatory, analgesic, aphrodisiac, diuretic and mildly sedative. It is an immune-modulator, antioxidant and hormone precursor which tends to regulate important physiological functions. It improves general alertness, prevents all types of weakness and increases strength and stamina. It also allays the stubborn and recurring infections of the urinary tract. It keeps the heart healthy and prevents free radical damage. It induces sound sleep and reduces inflammation.

DOSE:- 1 Capsule twice daily with plain water, after meals

2. Immune Booster

It is a polyherbal capsule containing grape seed (vitis vinifera), bhumi amla (Phyllanthus niruri), amalaki (Emblica officinalis), etc. It is sweet, astringent, bitter and pungent. It is light, dry and cold in effect. It contains alkaloids, glycosides, flavonoids, etc. It raises immunity and helps in fight day to day wear and tear of the body. It is used in fever, anemia, and disease of the urinary and genital tract. It also acts as a booster for all physiological systems of the body. It acts as hepato-protective and helps to manage liver diseases. It contains antioxidants which clear all the channels of the body and expel the toxins from the body and prevent ulcer by decreasing the amount of gastric acid. It is indicated in various diseases like cough, sore throat, indigestion, vomiting, hyperacidity, peptic ulcer, anemia, etc. it also allays the stubborn and recurring infections of the urinary tract. It keeps the heart healthy and prevents free radical damage.

DOSE:- 2 Capsules twice daily with plain water, after meals

3. Amalaki Rasayan

It is a single herbal capsule made from amalaki (emblica officinalis). It is at the same time sweet, astringent, bitter and pungent. It is dry, light and cold in effect. It is rich in protein, minerals, carbohydrates and fibre. The mineral and vitamin contents include calcium, phosphorus, iron, carotene and also vitamin b complex. It acts as an antipyretic, antioxidant, astringent, laxative, diuretic, aphrodisiac, antacid, and haemostatic. It is indicated in epistaxis, dysfunctional uterine bleeding, leucorrhoea, menopausal syndrome, general emaciation, hair and eye problems, jaundice, edema, cough and asthma. It also helps in healing the ulcers. It acts as a good antioxidant and also an adjunct in many chronic and wasting diseases.

DOSE:- 1 Capsule twice daily with plain water, after meals

4. Ashwagandha Capsules

It is a single herbal capsule made from ashwagandha (withania somnifera). It is sweet, bitter and astringent in taste and unctuous, light and hot in effect. It is tonic, rejuvenating and potent spermatogenic. It has a tonic effect on the brain and the nervous system. It acts as an anti-stress and adaptogenic medicine. It has anti inflammatory, analgesic, aphrodisiac, diuretic, and mildly sedative properties. It is also an immune-modulator, antioxidant and hormone precursor which tends to regulate important physiological functions. It is indicated in nervous and psychiatric disorders, arthritis, low backache, emaciation, impotency, hypertension and insomnia. It improves general alertness, prevents all types of weakness and increases body strength.

DOSE:- 2 Capsules twice daily with plain water, after meals

5. Shilajit Capsules

It is a single herbal capsule made from shilajit (asphaltum). It consists of rock humus, organic substances and rock minerals and components are resins, fatty acids, sterols, coumarins, gums, latex, albumins, triterpenes, phenolic lipids, aromatic carboxylic acids and amino acids. It has an anti inflammatory, anti tumor activity, antioxidant, anti-alzheimer, anti-asthmatic properties. It improves digestion related problems and enhances memory power. It controls the blood sugar in the body. It is beneficial in kidney, heart and liver diseases. It increases the hemoglobin in the body.

DOSE:- 1 Capsule twice daily with plain water or milk after meals

6. Gandhak Rasayan

It is a herbal tablet made from shuddha gandhak (purified sulfur). It is an antimicrobial, antibacterial, antipyretic, anti-allergic, anti-inflammatory antiviral and a broad spectrum antibiotic. It kills intestinal worms and is a good blood purifier. It contains various antioxidants. It is an immunity booster and indicated in infertility, debility, indigestion, breathlessness, abdominal pain. It detoxifies the blood, impurities, clears dirt and prevents secondary infection. It is very useful in urinary tract infection along with expelling the harmful pathogen from the body system.

DOSE:- 2 Tablets twice daily with lukewarm water

Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4030 (India), +91-172-521-4030 (Outside India) or Whatsapp at (+91) 9915-593-604

Conclusion

Severe combined immunodeficiency is the rare genetic condition in which genetic mutations occur which leads to alteration in function and development of immune cells. In ayurveda, we can correlate this disease with anuvanshik vyadhi (inherited disease) and other is oja kshaya (immune deficiency). There is no specific treatment for this disease but we can give supportive treatment to delay the progression of disease. We can use various kinds of herbs like shuddh gandhak, ashwagandha, amalaki, shilajit, bhumi amla, grape seed, etc which are very effective in this disease and provide immunity to the body. Herbal medicines like gandhak rasayan, telomere boostup, amalaki rasayan, ashwagandha capsules, etc.