Tag: Ayurveda for Sting Associated Vasculopathy of Infancy

Herbal Treatment for SAVI – Sting Associated vasculopathy infancy dependent

Abstract

SAVI that is Sting Associated vasculopathy can be defined as a disorder that causes abnormal inflammation to the entire body especially to the skin, lungs and the blood vessels. This is among the Autoinflammatory diseases. This disorder can also be categorised among the rarely found diseases. It is a hereditary condition found in neonates, this happens mainly due to mutations in the STING1 gene. It is a serious condition that can lead to a lot of systemic disorders. In Ayurveda SAVI is considered to be a Sahaja Roga that means a hereditary condition, this is due to Bija Dosha that is abnormality in the sperm, ova, chromosomes or the genes. This condition is among the rarely found diseases.

SAVI

Introduction

SAVI or Sting Associated Vasculopathy can be defined as a condition that causes inflammation throughout the body that affects especially the skin, blood vessels and lungs. This change in the body takes place due to mutation in genes that results in over production of inflammatory protein that harms the tissues and also causes inflammation. These genes start producing cytokines that mainly cause this inflammation. This disorder in infants occurs as lesions on the face especially to the nose and ears that can turn into ulcers and lately damages the tissue. This disorder has a higher risk to get into an infant if he or she has a positive family history. Involvement of lungs may be a cause of death in SAVI.

Causes

SAVI is caused mainly due to mutation of genes in STING1 (it physiologically makes a protein called STING) that dysfunctions and over produces. SAVI can be caused either due to a positive family history or may be due to abnormality in the cytoplasm of the tissues.

Signs And Symptoms Of Savi

  1. Lesions on skin like on fingers, cheeks, toes and soles
  2. Rashes and blisters on skin
  3. Stiffness of the joints
  4. Ulcerations can be found on the skin
  5. Difficulty in breathing, coughing or other interstitial lung disease (as lungs are affected)
  6. Nausea and vomiting
  7. Pain in abdomen
  8. Swelling and inflammation in hands and feet
  9. Weakness and fatigue
  10. Low grade Fever
  11. Diarrhoea
  12. Rigidity of joints
  13. Enlarged lymph nodes
  14. Dyspnea
  15. Patients may experience signs of Raynaud’s Phenomenon too

Diagnosis

For diagnosing SAVI following investigations may be required –

  • Physical examinations
  • Chest X Rays
  • Medical history of parents
  • CT (Computed Tomography) Scan
  • Complete blood count (CBC)
  • MRI (Magnetic Resonance Imaging)
  • Lung Biopsy
  • Skin biopsy
  • Genetic Testing

Treatment

In case of treatment of SAVI, symptomatic treatment can be given

  • Prevention of target organ damage that is the lungs
  • Supportive care to reduce other symptoms like fever, diarrhoea etc
  • Corticosteroids
  • Immunosuppressants
  • Antibiotics to prevent infection
  • Anti inflammatories

Complications

  • Lost mobility
  • Permanent organ damage
  • Scarring of the skin
  • Chronic inflammation
  • Gangrene can occur in tip of toes and fingers

Ayurvedic Aspect Of Sting Associated Vasculopathy Infancy Dependent (Savi)

Ayurveda considers this disorder Sting Associated vasculopathy Infancy Dependent is due to Bija dushti which means abnormality in the ovum or sperm or both. Acharya Charaka says that this abnormality may be due to defects in the chromosome or the genes.

Acharya charaka in (च. शा. ३/१७) says that when vitiation of any dosha causes abnormality to the Beeja bhag (that is the ova or the sperm) it can not work as it would have. And this is what causes the Sahaja Roga or Kulaj Rogas (hereditary disorders). So as the Beeja that is the seed of a new life is formed under abnormal conditions the offspring suffers from several disorders due to imbalance doshas that causes symptoms like stiffness of the joints, lesions or rashes on skin, dyspnea, growth retardation etc.

Treatment

The heredity or the genetic abnormalities cannot be undone or reversed. So Ayurveda does symptomatic treatment for this condition. This supportive treatment can be done to improve the symptoms. Planet Ayurveda has a list of drugs that improves this condition and to restrict further worsening of the symptoms.

Herbal Remedies By Planet Ayurveda For Sting Associated Vasculopathy Infancy Dependent (Savi)

Planet Ayurveda is an established and GMP certified and ISO approved brand that manufactures herbal supplements. Planet Ayurveda had a vision of reaching all over the globe and has achieved that. The raw materials used go through a quality check several times to ensure the use of the best quality product. All the herbal medications by them are 100% vegetarian and are free of adulterants, in fact no fillers or harmful preservatives are used. Planet Ayurveda is dedicated to use the ancient Science of healing Ayurveda to every doorstep. This company exports their products worldwide like to the USA, Europe, Africa and many other countries. All the products by Planet Ayurveda are manufactured following the ancient Ayurvedic texts under the guidance and supervision of experts of Ayurveda. They have plenty of medicines for various other diseases. Listed are few medicines that improve conditions caused due to SAVI.

Product List

  1. Boswellia Curcumin
  2. Arvindasav
  3. Infee Syrup
  4. Manjishtha Capsules

Description of the products

1. Boswellia Curcumin

Boswellia-Curcumin manufactured by Planet Ayurveda in the form of capsules are made of a combination of two effective herbs Shallaki (𝘉𝘰𝘴𝘸𝘦𝘭𝘭𝘪𝘢 𝘴𝘦𝘳𝘳𝘢𝘵𝘢) and Haridra (𝘊𝘰𝘳𝘤𝘶𝘮𝘪𝘯 𝘭𝘰𝘯𝘨𝘢). It reduces inflammation caused to the blood vessels and due to haridra that has antibacterial properties if heals the ulcers of the skin and shows effective result in discoloration of the skin.

Dosage– 1 capsule twice a day with plain water after meals.

2. Arvindasav

This preparation in the form of syrup has several herbal drugs like khairati(𝘚𝘪𝘥𝘢 𝘤𝘰𝘳𝘥𝘪𝘧𝘰𝘭𝘪𝘢), manjith(𝘙𝘶𝘣𝘪𝘢 𝘰𝘳𝘥𝘪𝘧𝘰𝘭𝘪𝘢), arjun(𝘛𝘦𝘳𝘮𝘪𝘯𝘢𝘭𝘪𝘢 𝘢𝘳𝘫𝘶𝘯𝘢) and various other drugs that pacifies all the three doshas of the body Vata, Pitta and Kapha. Due to the cooling effect of the drugs used in Arvindasav it acts as an antipyretic that is helpful in fever.

Dosage– 10 – 20 ml with equal amount of water, twice or thrice a day after meals.

3. Infee Syrup

This syrup has the goodness of Yashtimadhu (𝘎𝘭𝘺𝘤𝘺𝘳𝘳𝘩𝘪𝘻𝘢 𝘨𝘭𝘢𝘣𝘳𝘢) and Guduchi (𝘛𝘪𝘯𝘰𝘴𝘱𝘰𝘳𝘢 𝘤𝘰𝘳𝘥𝘪𝘧𝘰𝘭𝘪𝘢).This combination helps the infant relieve from weakness or fatigue. It also has properties of an immunomodulator that improves the overall immune system of the body.

Dosage-For Infants – 5-10 drops twice a day with water & For children – ½ – 1 teaspoon a day with water

4. Manjishtha Capsules

These capsules by Planet Ayurveda are made of extract of a single drug Manjishtha (𝘙𝘶𝘣𝘪𝘢 𝘤𝘰𝘳𝘥𝘪𝘧𝘰𝘭𝘪𝘢), this drug is known to improve texture of skin that ultimately helps in symptoms caused by SAVI to the skin. It works predominantly on Pitta dosha and does Rakta shodhana (𝘱𝘶𝘳𝘪𝘧𝘪𝘤𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘣𝘭𝘰𝘰𝘥) that supports healthy skin too.

Dosage– 1- 2 capsules twice a day with plain water after meals

Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4030 (India), +91-172-521-4030 (Outside India) or Whatsapp at (+91) 9915-593-604

Conclusion

Hence we can conclude that this autoinflammatory disorder SAVI (Sting Associated vasculopathy infancy dependent) is a rarely found disease that occurs due to abnormal gene mutation causing inflammation of the entire body and can affect the lungs too that can cause severity. This is a hereditary condition. In ayurveda this condition can be correlated to sahaja rogas which is due to Bija Dosha that is any kind of abnormality in the sperm or the ovum or genes or the chromosomes. In modern Science there are symptomatic treatments for this condition. Planet Ayurveda by following all the ancient scriptures of Ayurveda has a list of above mentioned products that improves this condition.

Herbal Remedies for SAVI – String-Associated Vasculopathy Infancy Dependent

ABSTRACT

It is a rare autoinflammatory disease. SAVI causes severe lung disease and interstitial lung disease. It occurs due to mutations in the STING1 gene which gives the instruction for making STING (stimulator of interferon genes) protein. It involves the abnormal inflammation in the body that is in the skin, lungs, and blood vessels. Inflammation normally occurs when the white blood cells of our body reach the site of injury to fight against bacteria and help in tissue repair. Excessive inflammation damages the tissues and cells of our body. Inflammation occurs due to autoinflammatory disease.

INTRODUCTION

SAVI is an inflammation of the body due to a mutation in the STING1 gene in the body. It starts from the first few months of life. The signs and symptoms are mostly of blood vessels and damage to tissue. As an infant suffers from SAVI the lesions occur on the face, nose, and ears. These lesions start in the form of lesions and turn into ulcers and lastly tissue damage. The skin problems mostly worsen in cold weather. Due to abnormal blood vessels in the skin, the skin turns into purplish discoloration. People affected with SAVI also experience symptoms of Raynaud phenomenon as fingers and toes turn white or blue in colour due to exposure to cold temperatures and any type of stress.

autoinflammatory disease

PATHOPHYSIOLOGY

When the protein content STING shifts to its normal position the SAVI disease occurs. Normally, the STING protein is present in the cytoplasm of cells but in this condition, the protein is present in the Golgi apparatus.

CAUSES

The main cause of SAVI is mutation in STING1 genes. There are some risk factors that cause SAVI are described below-

  1. A positive family history
  2. Abnormality in the cytoplasm of cells

SYMPTOMS

The SAVI includes the following symptoms

  1. Interstitial lung disease
  2. Skin lesions on fingers, cheeks, nose, toes and soles
  3. Myositis (when the immune system attacks the muscles of the body)
  4. Joint stiffness
  5. Rashes on skin
  6. Blisters on skin
  7. Ulcer in the mucous membrane
  8. Ulcers on the skin
  9. Abdominal pain
  10.  Difficulty in breathing
  11.  Swelling and inflammation in hands and feet
  12.  Vomiting
  13.  Diarrhea
  14.  Fever
  15.  Anemia
  16.  Fatigue

DIAGNOSIS

The SAVI include the following diagnosis

  1. Clinical examination
  2. Evaluation of medical history
  3. Assess the signs and symptoms of patients
  4. Blood test- ESR (erythrocyte sedimentation rate) and C-reactive protein are elevated
  5. Skin biopsy- Shows the inflammation of capillaries
  6. Lung biopsy- Shows the follicular hyperplasia and fibrosing alveolitis

COMPLICATION

The SAVI includes the following complications

  1. Chronic inflammation
  2. Scarring of skin
  3. Disfigurement of skin
  4. Loss of mobility
  5. Organ damage mostly involves the lung
  6. Gangrene forms on the tips of the finger

TREATMENT

The treatment includes the following

  1. Control the inflammation
  2. Prevent organ damage
  3. Supportive care is given to reduce symptoms
  4. Steroids – To reduce inflammation
  5. Antibiotics -To prevent infections
  6. Immunosuppressant – To suppress the immune system

AYURVEDA ASPECT FOR STRING-ASSOCIATED VASCULOPATHY INFANCY DEPENDANT

  • As  Acharya Charak explained in Sharira sthana च.शा.०३ chapter खुडाक गर्भावकृान्ति शारीर (Khuddika Garbhavkranti Sharira ) explained बीज दुष्टि (defect in ovum and sperm).
  • The defect in the ovum and sperm is due to 3 reasons: बीज (sperm and ova), बीज भाग (chromosomes), and बीज भाग अवयव (genes). In च.शा.०४।०४ the 7 भाव (qualities) are described by Acharya Charak that is  मातृज भाव (maternal factor), पितृज भाव (paternal factor), आत्मज भाव (soul),   सात्मयज भाव (wholesomeness), रसज भाव (nutritional factor), and सत्वज भाव (psych/mind). The disorder is found before the birth so considered in  सहज रोग.
  • As the dosha is vitiated the signs and symptoms are seen according to the severity of the disease.

HERBAL REMEDIES FOR STRING-ASSOCIATED VASCULOPATHY INFANCY DEPENDANT BY PLANET AYURVEDA

Planet Ayurveda is GMP-certified. Their products are 100% pure, easy to use and free from any type of adulterant, preservatives, fillers, yeast, and chemicals. The products are prepared under the guidance of an M.D. Ayurveda experts. The products are effective and have no side effects. The herbal remedies by planet Ayurveda for string-associated vasculopathy infancy dependant-

Product list

  1. Boswellia curcumin
  2. Arvindasav
  3. Syrup Infee
  4. Manjishtha capsules

Product Description

1. Boswellia curcumin

The Boswellia capsules contain Curcumin (Curcuma longa), and Shallaki (Boswellia serrata). Inflammation in blood vessels and lungs is associated with SAVI so curcumin helps to reduce inflammation as it has anti-inflammatory properties. Curcumin also reduces muscle weakness, and muscle pain and protects from muscle damage. As skin discoloration and ulcers form on the skin, the shallaki helps to reduce those symptoms.

Dosage– 1 capsule twice daily, with plain water, after meals

2. Arvindasav

The Arvindasav has a mixture of many herbs as it contains Bach (Acorus calamus), Kachoor (Curcuma zedoaria), Amla (Embilica officinalis), Sarva (Hemidesmus indicus), Sarfonka (Tephrosia), water and many more herbs. As a mental weakness, jatamansi helps to improve mental weakness. As skin discoloration is there amla improves skin complexion. As Arjuna has antioxidant properties it prevents the formation of free radicals that cause skin damage. Munakka has anti-microbial and anti-inflammatory properties; it reduces bacterial infections and also reduces inflammation.

Dosage– 2 teaspoons daily after meals

3. Syrup Infee

The syrup contains extract of Yashtimadhu (Glycyrrhiza glabra) and Guduchi (Tinospora cordifolia). Yashtimadhu helps to improve the degeneration process, and skin-related problems, and reduces weakness or fatigue of the body. Guduchi has the property of immunomodulator which helps to improve the immune system of the body.

Dosage– 2 teaspoons twice daily with water

4.  Manjishtha capsules

The capsules are made up of a single extraction of Manjistha (Rubia cordifolia).Skin discoloration associated with SAVI Manjistha helps the skin for its natural color, it also reduces the ulcers and blisters present on the skin.  Manjistha contains madhura, tikta, and kshaya rasa so pacifying the pitta dosha and helpful in reducing fever. It contains astringent properties so reduces mobility and is helpful to treat diarrhoea. It promotes skin glow in both ways, internally and externally.

Dosage– 1 capsule twice daily, with plain water, after meals.

Contact Planet Ayurveda Support Team to provide you the costing/ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 842-749-4030.

CONCLUSION

In this article, we talk about the introduction, causes, symptoms, diagnosis, and treatment of string-associated vasculopathy infancy dependent. As the doshas are imbalanced there is an imbalance in the functioning of the body. In Ayurveda च.शा.०३ chapter खुडाक गर्भावकृान्ति शारीर tell about the बीज दुष्टि. Where defect in ovum and sperm at the time of fusion of gametes. There are three main reasons for this defect in the ovum and sperm, genes, and chromosomes. As this disease is hereditary it is considered in सहज रोग. The planet Ayurveda provides herbal remedies to treat the string associated with vasculopathy infancy dependent Boswellia curcumin, Arvindasav, Syrup Infee, and Manjishtha capsules.