Tag: Herbal Products for Sting Associated Vasculopathy of Infancy

October 6, 2023

Herbal Remedies for SAVI – String-Associated Vasculopathy Infancy Dependent

ABSTRACT

It is a rare autoinflammatory disease. SAVI causes severe lung disease and interstitial lung disease. It occurs due to mutations in the STING1 gene which gives the instruction for making STING (stimulator of interferon genes) protein. It involves the abnormal inflammation in the body that is in the skin, lungs, and blood vessels. Inflammation normally occurs when the white blood cells of our body reach the site of injury to fight against bacteria and help in tissue repair. Excessive inflammation damages the tissues and cells of our body. Inflammation occurs due to autoinflammatory disease.

INTRODUCTION

SAVI is an inflammation of the body due to a mutation in the STING1 gene in the body. It starts from the first few months of life. The signs and symptoms are mostly of blood vessels and damage to tissue. As an infant suffers from SAVI the lesions occur on the face, nose, and ears. These lesions start in the form of lesions and turn into ulcers and lastly tissue damage. The skin problems mostly worsen in cold weather. Due to abnormal blood vessels in the skin, the skin turns into purplish discoloration. People affected with SAVI also experience symptoms of Raynaud phenomenon as fingers and toes turn white or blue in colour due to exposure to cold temperatures and any type of stress.

autoinflammatory disease

PATHOPHYSIOLOGY

When the protein content STING shifts to its normal position the SAVI disease occurs. Normally, the STING protein is present in the cytoplasm of cells but in this condition, the protein is present in the Golgi apparatus.

CAUSES

The main cause of SAVI is mutation in STING1 genes. There are some risk factors that cause SAVI are described below-

  1. A positive family history
  2. Abnormality in the cytoplasm of cells

SYMPTOMS

The SAVI includes the following symptoms

  1. Interstitial lung disease
  2. Skin lesions on fingers, cheeks, nose, toes and soles
  3. Myositis (when the immune system attacks the muscles of the body)
  4. Joint stiffness
  5. Rashes on skin
  6. Blisters on skin
  7. Ulcer in the mucous membrane
  8. Ulcers on the skin
  9. Abdominal pain
  10.  Difficulty in breathing
  11.  Swelling and inflammation in hands and feet
  12.  Vomiting
  13.  Diarrhea
  14.  Fever
  15.  Anemia
  16.  Fatigue

DIAGNOSIS

The SAVI include the following diagnosis

  1. Clinical examination
  2. Evaluation of medical history
  3. Assess the signs and symptoms of patients
  4. Blood test- ESR (erythrocyte sedimentation rate) and C-reactive protein are elevated
  5. Skin biopsy- Shows the inflammation of capillaries
  6. Lung biopsy- Shows the follicular hyperplasia and fibrosing alveolitis

COMPLICATION

The SAVI includes the following complications

  1. Chronic inflammation
  2. Scarring of skin
  3. Disfigurement of skin
  4. Loss of mobility
  5. Organ damage mostly involves the lung
  6. Gangrene forms on the tips of the finger

TREATMENT

The treatment includes the following

  1. Control the inflammation
  2. Prevent organ damage
  3. Supportive care is given to reduce symptoms
  4. Steroids – To reduce inflammation
  5. Antibiotics -To prevent infections
  6. Immunosuppressant – To suppress the immune system

AYURVEDA ASPECT FOR STRING-ASSOCIATED VASCULOPATHY INFANCY DEPENDANT

  • As  Acharya Charak explained in Sharira sthana च.शा.०३ chapter खुडाक गर्भावकृान्ति शारीर (Khuddika Garbhavkranti Sharira ) explained बीज दुष्टि (defect in ovum and sperm).
  • The defect in the ovum and sperm is due to 3 reasons: बीज (sperm and ova), बीज भाग (chromosomes), and बीज भाग अवयव (genes). In च.शा.०४।०४ the 7 भाव (qualities) are described by Acharya Charak that is  मातृज भाव (maternal factor), पितृज भाव (paternal factor), आत्मज भाव (soul),   सात्मयज भाव (wholesomeness), रसज भाव (nutritional factor), and सत्वज भाव (psych/mind). The disorder is found before the birth so considered in  सहज रोग.
  • As the dosha is vitiated the signs and symptoms are seen according to the severity of the disease.

HERBAL REMEDIES FOR STRING-ASSOCIATED VASCULOPATHY INFANCY DEPENDANT BY PLANET AYURVEDA

Planet Ayurveda is GMP-certified. Their products are 100% pure, easy to use and free from any type of adulterant, preservatives, fillers, yeast, and chemicals. The products are prepared under the guidance of an M.D. Ayurveda experts. The products are effective and have no side effects. The herbal remedies by planet Ayurveda for string-associated vasculopathy infancy dependant-

Product list

  1. Boswellia curcumin
  2. Arvindasav
  3. Syrup Infee
  4. Manjishtha capsules

Product Description

1. Boswellia curcumin

The Boswellia capsules contain Curcumin (Curcuma longa), and Shallaki (Boswellia serrata). Inflammation in blood vessels and lungs is associated with SAVI so curcumin helps to reduce inflammation as it has anti-inflammatory properties. Curcumin also reduces muscle weakness, and muscle pain and protects from muscle damage. As skin discoloration and ulcers form on the skin, the shallaki helps to reduce those symptoms.

Dosage– 1 capsule twice daily, with plain water, after meals

2. Arvindasav

The Arvindasav has a mixture of many herbs as it contains Bach (Acorus calamus), Kachoor (Curcuma zedoaria), Amla (Embilica officinalis), Sarva (Hemidesmus indicus), Sarfonka (Tephrosia), water and many more herbs. As a mental weakness, jatamansi helps to improve mental weakness. As skin discoloration is there amla improves skin complexion. As Arjuna has antioxidant properties it prevents the formation of free radicals that cause skin damage. Munakka has anti-microbial and anti-inflammatory properties; it reduces bacterial infections and also reduces inflammation.

Dosage– 2 teaspoons daily after meals

3. Syrup Infee

The syrup contains extract of Yashtimadhu (Glycyrrhiza glabra) and Guduchi (Tinospora cordifolia). Yashtimadhu helps to improve the degeneration process, and skin-related problems, and reduces weakness or fatigue of the body. Guduchi has the property of immunomodulator which helps to improve the immune system of the body.

Dosage– 2 teaspoons twice daily with water

4.  Manjishtha capsules

The capsules are made up of a single extraction of Manjistha (Rubia cordifolia).Skin discoloration associated with SAVI Manjistha helps the skin for its natural color, it also reduces the ulcers and blisters present on the skin.  Manjistha contains madhura, tikta, and kshaya rasa so pacifying the pitta dosha and helpful in reducing fever. It contains astringent properties so reduces mobility and is helpful to treat diarrhoea. It promotes skin glow in both ways, internally and externally.

Dosage– 1 capsule twice daily, with plain water, after meals.

Contact Planet Ayurveda Support Team to provide you the costing/ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 842-749-4030.

CONCLUSION

In this article, we talk about the introduction, causes, symptoms, diagnosis, and treatment of string-associated vasculopathy infancy dependent. As the doshas are imbalanced there is an imbalance in the functioning of the body. In Ayurveda च.शा.०३ chapter खुडाक गर्भावकृान्ति शारीर tell about the बीज दुष्टि. Where defect in ovum and sperm at the time of fusion of gametes. There are three main reasons for this defect in the ovum and sperm, genes, and chromosomes. As this disease is hereditary it is considered in सहज रोग. The planet Ayurveda provides herbal remedies to treat the string associated with vasculopathy infancy dependent Boswellia curcumin, Arvindasav, Syrup Infee, and Manjishtha capsules.

Continue Reading

September 28, 2023

Sting Associated Vasculopathy Infancy Dependent Treatment in Ayurveda

Abstract

Sting-associated vasculopathy is an uncommon disorder that causes aberrant inflammation and skin and interstitial lung disease lesions. It was originally found in 2014. Because of the gene mutation that results in it, it is a hereditary condition. High death rates are associated with its characteristic neonatal onset. Now, we discuss sting-associated vasculopathy in detail. The affected person experiences the Raynaud phenomenon, in which the affected area turns red with exposure to cold and stress and changes color from white to blue. It might also be required for amputation.

Sting Associated Vasculopathy, Infancy Dependent

Introduction

The hereditary disorder known as “sting-associated vasculopathy” causes aberrant inflammation throughout the body, with the skin, blood vessels, and lungs experiencing the most of the effects. It is an auto-inflammatory illness and a rare condition. It begins during infancy. Vasculopathy and interstitial lung disease are its primary characteristics.

Causes of SAVI

Genetic changes are the root cause of sting-associated vasculopathy. A mutation in the STING1 gene results in an overproduction of the inflammatory proteins that harm tissue and increase inflammation. This gene is important for producing the STING protein, which produces cytokines that cause inflammation.

Symptoms Of SAVI

  • Unhealing wound
  • Minimal fever
  • Joint rigidity
  • Muscle soreness
  • Dyspnea
  • Respiratory lesions
  • Enlarged lymph node
  • Failing to flourish
  • Coughing
  • Lungs with interstitial disease
  • Hypermobility
  • Skin blemishes can be found on the cheeks, nose, ears, fingers, and soles of the feet.
  • A fibrotic lung

Diagnosis Of SAVI

  • Chest X-rays
  • Magnetic resonance imaging
  • Blood culture
  • Lung biopsy
  • CT scan
  • Genetic testing

Treatment

This illness has no specific treatment. Management can only be supportive.

  • Corticosteroids
  • Biological agents
  • Immunosuppressant

Ayurvedic Aspect of Sting Associated Vasculopathy

In Ayurveda, we can correlate the sting-associated vasculopathy with onset in infancy with Bija dushti (Abnormal ovum and sperm).

According to Acharya Charaka: (च. शा. ३/१७)

This theory holds true for each and every srota (channel). Any Beeja Bhaga gene whose function is compromised by the doshas (Vata, Pitta, and Kapha) manifests as a sickness or disease. It falls under the heading of a hereditary disease called Sahaja or Kulaj roga. Genes, or bija bhaga avayava, are the fundamental building blocks of all living things. Genes contain the instructions needed to create, maintain, and pass genetic features to progeny in an organism. If the male and female are both bija damaged totally, neither can generate new offspring, but if just one is contaminated, the offspring will be defective. The bija bhaga avayava is where abnormal doshas (Vata, Pitta, and Kapha) enter, causing disease to develop there with symptoms like dyspnea, growth retardation, skin lesions, joint stiffness, and pulmonary diseases.

Treatment

Genetic or hereditary illnesses cannot be cured. There is no known cure for this illness. Only supportive care can be provided to control symptoms and halt the spread of the disease. The following list of herbal treatments for SAVI is provided by Planet Ayurveda as supportive management.

Some Herbal Remedies for Sting Associated Vasculopathy by Planet Ayurveda

Planet Ayurveda is a certified ayurvedic clinic, and the formulation of different types of remedies is performed here to provide relief from diseases. All formulations at Planet Ayurveda are made organically without the use of preservatives. These remedies are formulated under the guidance of MD Ayurvedic practitioners. Planet Ayurveda offers a variety of herbal products that have no negative effects for treating sting associated vasculopathy.

Product Lists

  1. BOSWELLIA CURCUMIN
  2. ARVINDASAV
  3. INFEE SYRUP
  4. MANJISHTHA CAPSULE

Product Description

1. Boswellia Curcumin

Boswellia curcumin is a multi-herbal capsule that includes haridra (Curcuma longa) and shallaki (Boswellia serrata). It has a spicy and bitter flavour. It harmonizes the body’s three doshas—Pitta, Kapha, and Vata. It is unctuous, dry, sticky, sharp, and light. It includes mineral stuff such as calcium, silicon dioxide, iron, volatile oil, and magnesium, as well as organic molecules and inorganic ions. For a variety of joint issues, including osteoarthritis, gout, and rheumatoid arthritis, it is a very helpful medication. It aids in lowering joint inflammation-related discomfort, soreness, and swelling.

Dosage: with plain water, after meals, take 1 capsule twice daily.

2. Arvindasav

Arvindasav is a multi-herbal formulation that is formulated by Planet Ayurveda by using herbs like arjun (Terminalia arjuna), khairati (Sida cordifolia), mulethi (Glycyrrhiza glabra), manjith (Rubia cordifolia), and some other herbs. It has an unctuous, rich, heavy, and cold effect. All three doshas—Vata, Pitta, and Kapha—are calmed by it. It is a drug that acts as an antipyretic, anti-inflammatory, and wound healer. It enhances the complexion, soothes eye issues, acts as an antacid, and is also a potent general tonic. Calcium, glucose, starch, vitamin B, and potassium are all present in it. It liquifies the mucus and helps in its smooth excitation. It is indicated for cough, asthma, bronchitis, and other chest conditions. It enhances voice quality, supports body weight, and counteracts excessive thirst and weariness. It stimulates the digestive system.

Dosage: after meals, with equal amounts of water (10 ml twice daily).

3. Infee Syrup

Infee is a multi-herbal syrup that is formulated with the help of yashtimadhu (Glycyrrhiza glabra) and guduchi (Tinospora cordifolia). It balances the kapha, pitta, and vata-vitiated doshas. Additionally, it has antipyretic, anti-inflammatory, and wound-healing properties. It is unctuous, spicy, astringent and bitter. Fatty acids, alkaloids, volatile oils, and glycosides are all present. It is prescribed for conditions like gout, rheumatoid arthritis, fever, dyspepsia, and urinary disorders. It contains rejuvenating, immunomodulating, and antioxidant effects. It helps reduce the level of uric acid.

Dosage: 5 drops in infants and 1/2 tsp with water.

4. Manjishtha Capsules

Manjistha capsules are a single herbal formulation that is formulated by Planet Ayurveda with the help of Manjistha (Rubia cordifolia). It is a blood purifier, detoxifier, hematopoietic system booster, and complexion enhancer. Additionally, it functions as an antibacterial, hemostatic, digestive, and carminative agent. It has uterine stimulant and anti-inflammatory effects. It has a hot, dry, and heavy effect while tasting bitter, astringent, and sweet. It calms down the kapha and pitta doshas. It is advised in cases of dysentery, persistent fever, diarrhea, and uterine and urinary infections. It helps with scars, acne and blemishes and also repairs the skin tissues that have been harmed or infected.

Dosage: after meals, with plain water, 1 capsule twice daily.

Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 9915-593-604

Conclusion

Sting-associated vasculopathy is an uncommon disorder that causes aberrant inflammation and skin and interstitial lung disease lesions. It was originally found in 2014. Because of the gene mutation that results in it, it is a hereditary condition. It is an auto-inflammatory illness and a rare condition. It begins during infancy. Vasculopathy and interstitial lung disease are its primary characteristics. In Ayurveda, we can correlate the sting-associated vasculopathy with onset in infancy with Bija dushti (Abnormal ovum and sperm). On Planet Ayurveda, there are some herbal formulations that are used for the management of sting-associated vasculopathy without causing any side effects.

Continue Reading

Click the CROSS button to close