Tag: Herbs for Glanzmann Thrombasthenia

Glanzmann Thrombasthenia Symptoms, Causes And Treatment By Ayurveda

Abstract

Platelets are essential for proper blood clotting. Any deformity in their production and functioning is a serious problem. Glanzmann Thrombasthenia is a congenital bleeding disorder that occurs due to the impaired functioning of platelets. This is inherited from the parents to the child, with an equal risk of having the disorder in both male and female children. This disorder is mainly seen in populations that practice intermarriages. In this article, we will be discussing various causes and symptoms of Glanzmann Thrombasthenia. Also, we will discuss the ayurvedic treatment for this disease.

Glanzmann Thrombasthenia

Introduction

Glanzmann Thrombasthenia is a rare but serious platelets disorder in which there is abnormal bleeding from different parts of the child. The symptoms begin at birth or shortly after some time of the child’s birth. There is difficulty in getting blood to clot and the child becomes bruised or loses a large quantity of blood. This is an autosomal recessive condition and both parents need to have an abnormal gene in order to inherit it into their child. Untreated Glanzmann Thrombasthenia can lead to hemorrhages which may be a life-threatening condition.

Ayurvedic Aspect

We can correlate Glanzmann’s Thrombasthenia with “Raktapitta” in Ayurveda. Raktapitta is a hemorrhagic disorder in which bleeding occurs from various parts of the body. The bleeding disorders according to Ayurveda occur due to an imbalance of tridosha and excess accumulation of Pitta dosha. This excessive pitta dosha contaminates the rakt (blood), which also toxicate the blood channels throughout the body. The Pitta dosha along with Vata and Kapha dosha causes the oozing of blood from the openings of the body that are characterized accordingly.

 Causes

  • Glanzmann Thrombasthenia occurs due to the lack of protein (Fibrinogen) that is on the surface of platelets.
  • The protein is essentially needed to join/clump the blood cells together. The absence of protein causes this disease. This lack of protein is caused due to various genital abnormalities and mutations.
  • Autoimmune diseases
  • Certain infections
  • Leukemia

The cause of Raktpitta according to Ayurveda are

  • Pitta dosha vardhak Aahar and Vihar
  • Excess anger
  • Consuming Katu (spicy), lavana (Salty), and amla (Sour) is excess in diet.

Symptoms

Symptoms of Glanzmann Thrombasthenia include abnormal Mucosal bleeding from different body parts in the child at birth or shortly thereafter birth. The infant tends to bruise easily with the following symptoms.

  •  Gastrointestinal bleeding (bleeding anywhere in the GI tract)
  •  Gingival bleeding (bleeding from gums)
  •  Epistaxis (Nose bleeding)
  •  Petechiae
  •  Purpura
  •  Hematuria (Blood in urine)
  •  Bleeding after or during surgery

Women with this disorder have

  •  Menorrhagia
  •  Abnormal uterine bleeding

Diagnosis

The diagnosis is ruled out for proper finding of the disorder

  •  Complete blood count
  •  Platelet count
  •  Bleeding time
  •  Clotting time- Prothrombin time test
  •  Platelet aggregation study
  •  DNA analysis
  •  Prenatal analysis
  •  Blood protein deficiency test
  •  Genetic tests

Treatment

The standard treatment followed in Glanzmann Thrombasthenia is

  • Blood platelet transfusion (throughout life)
  • Bone marrow transplantation
  • Hormonal therapy
  • Symptomatic treatment-
  • Nasal packaging (in nose bleeding)
  • Dental care (in gums bleeding)
  • Antifibrinolytic agents (in GIT bleeding)
  • Genetic counseling
  • Surgery

Herbal remedies for Glanzmann Thrombasthenia by Planet Ayurveda

Planet Ayurveda provides pure forms of medications that effectively manage the condition without any delay or side effects. Proper medications and doses are to be consumed as directed by the doctors of Planet Ayurveda. The medications are manufactured very carefully for the consumption of children. They are pure herbal extracts with no added chemicals that may affect the immunity and health of your child. The priority medications used in Glanzmann Thrombasthenia by Planet Ayurveda are

Product List

1. Immune Booster

2. Giloy Ghan Vati

3. Kumar Kalyan Ras

4. Swarn Vasant Malti Ras

5. Green Essentials

6. Punarnava Mandur

7. Spirulina Capsules

Herbal Remedies For Glanzmann Thrombasthenia

Herbal Remedies For Glanzmann Thrombasthenia

Products Description

1. Immune Booster

Immunity booster is an herbal preparation prepared from Grape seed (Vitis vinifera), Bhumi amla (Phyllanthus niruri), Amalaki (Phyllanthus emblica), etc. These tablets rebuild the whole immune system by strengthening immunity and eliminating all toxins/ailments from the body of the child and recovering general health by easing the symptoms of this bleeding disorder.

Dosage  Have 2 capsules twice daily

2. Giloy Ghan Vati

The giloy ghan Vati is prepared from Giloy (Tinospora cordifolia) and is used to maintain the normal levels of tridoshas in the body. These natural tablets effectively maintain the healthy tissues and blood cells in the body that keep the child healthy.

Dosage  Have 2 Vatis twice daily

3. Kumar Kalyan Ras

This is an herbal ayurvedic formulation having a mixture of wonderful herbs used effectively for the maintenance of general health and overall immunity of the child. It contains Kumari ras (Aloe vera), Bhasma (Calx) of Parada (mercury), Swarna (Gold), Makshik (Copper), Abhraka (Mica), Loha (Iron), etc. mainly it is prescribed in pediatric disorders (disorders in children). The medicine is indicated to be taken with guidance from an Ayurvedic Doctor.

Dosage  One tablet to be chewed twice daily

4. Swarn Vasant Malti Ras

This is a dietary supplement for the maintenance of healthy body immunity and normal temperature of a child that contains Bhasma (Calx) of Gold and Mukta, etc. These supplements balance Vata and Kapha dosha and support healthy respiratory functioning.

 Dosage  One tablet to be chewed twice daily

5. Green Essentials

These essential capsules are prepared from Grape seed (Vitis vinifera), Wheatgrass (Triticum Aestivum), Green tea (Camellia sinensis), etc. This natural product supports a healthy immune system and helps to maintain the overall health of the person. These capsules are known to have various health benefits due to their superfood ingredients. Consuming these essentials on a regular basis eases the symptoms of Glanzmann’s Thrombasthenia.

Dosage  Have 2 capsules twice daily

6. Punarnava Mandur

These tablets are the classical formulations of Planet Ayurveda helpful to improve blood count, and blood quality and removing toxins from the body through urine or sweat. These tablets contain Punarnava (Boerhaavia diffusa), Chavya (Piper chaba), Mandoor Bhasma (Ferric oxide calx), etc. These tablets reduce the inflammation in the child and also reduce the risk of disorders that have maximum chances to occur in a newborn such as jaundice, pedal edema, Glanzmann’s Thrombasthenia, etc.

Dosage  Have 2 tablets twice daily

7. Spirulina Capsules

These tablets contain Spirulina which is the powerhouse of many health benefits. It is a natural multivitamin supplement that removes all ailments from the body. It improves stamina, eyesight, hemoglobin levels, and energy levels in the body. These tablets are stuffed with a lot of micronutrients that have strong antioxidant and immune-boosting properties.

Dosage  Have 2 capsules twice daily

CONTACT PLANET AYURVEDA TO PROVIDE YOU THE COSTING / ORDERING AND DELIVERY INFORMATION AT – COSTING.PLANETAYURVEDA@GMAIL.COM OR CALL AT +91-172-5214040

Conclusion

Thus we can conclude that Ayurveda medicines are efficient enough to maintain immunity and help overcome many bleeding disorders in children. Our talented doctors prescribe the required medication to the children after analyzing each aspect and possibility. Our medicines are 100% pure and do not have any side effects. For more queries contact us at www.PlnaetAyurveda.com

 

Ayurvedic Perspective of Glanzmann Thrombasthenia – Platelet Disorders

ABSTRACT

Glanzmann Thrombasthenia is a bleeding syndrome type of rare autosomal recessive and characterised by platelet aggregation. GT is associated with clinical variability: some of them mild bruising but sometimes it occurred large blood vessels haemorrhage. Haematuria and gastrointestinal bleeding are less common but some of the characteristic sites of the bleeding are purpura, epistasis, gingival haemorrhage etc. In most cases, bleeding symptoms present afterlife but GT is diagnosed in later life. In the modern system of medicine full cure for treating this disease is not available; they, at last, transfuse platelets when no other option is left. This is not the proper way to treat any disease because after some time the platelets count decreased again. Ayurveda has many herbs indicating bleeding disorders that will definitely increase platelet count in a restorative way.

INTRODUCTION

Platelets are a very important component in stopping any kind of bleeding as in the case of hemostasis. In Hemostasis damaged sub endothelium releases adhesive proteins and fibrinogen which are attached to the site of injury with platelets and form a platelet plug. Platelets provide a surface for the attachment of coagulation factors. Then this will activate platelets to form a thrombus. Any kind of defect in this mechanism or process can cause bleeding disorders.

Glanzmann first described this in the year 1918 and called it “hereditary hemorrhagic thrombasthenia”. Its main characteristic features for diagnosis are prolonged bleeding time, clumped platelets and the appearance of platelets on a peripheral blood smear.

GLANZMANN THROMBASTHENIA

DIFFERENTIAL DIAGNOSIS

Platelet aggregation defects which are mainly due to adenosine diphosphate (ADP) or collagen can mimic Glanzmann thrombasthenia.  But GT has one specific feature of clot retraction. It is also sometimes misdiagnosed as Bernard- souler syndrome and vonwillebrand disease due to the involvement of platelet aggregation in both

AETIOLOGY

Megakaryocytes are present in the bone marrow and on maturity, they liberate large no. of platelets into the blood. In GT platelets can’t be aggregated in response to natural agonists while they are present in their normal shape. The genes which are defected in this disease are present on chromosome 17 of DNA. This is an autosomal recessive condition which means it occurs only if both parents are having this disease

SYMPTOMS OF GLANZMANN DISEASE

  1. Nose bleeding(Epistasis)
  2. Bruising easily
  3. Bleeding gums
  4. Heavy menstrual bleeding
  5. Bleeding during or after surgery
  6. Mucocutaneous bleeding

DIAGNOSIS

The clinical manifestation of some diseases is the same sometimes as in the case of  GT and other cases of platelet aggregation. The main diagnostic test for GT are:

  1. Normal platelet count
  2. Bleeding time
  3. Light transmission aggregometry
  4. Platelet function analyser
  5. Flow cytometry
  6. Mutation analysis

AYURVEDIC VIEW

In Ayurveda the body depends on anna(food) and other four factors namely vat, pitta, kapha and rakta . The rakta is considered to be the most important in it because any type of injury internal or external or any coagulation disorder leads to morbidity or mortality. This Glanzman thrombasthenia can be correlated with the rakta pitta it is said to be mahavega or mahagada by acharya charak mentioned in the classical medicinal textbooks of Ayurveda. In this disorder vitiation of pitta is the main cause of the disorder. Pitta is also called lohit pitta because it comes into touch with blood and can cause disease in the blood.

The treatment of bleeding disorder in Ayurveda can be done by shudha dravya varga which is highly composed of calcium carbonate, calcium sulphate, calcium fluoride etc. calcium helps in the coagulation of bleed; it is the important factor in the stoppage of blood. Thus shudha vargiya dravya helps in the coagulation of blood and pacifies the pitta and rakta dushti. Many kinds of animal origin, herbal origin and mineral origin are mentioned in Ayurveda for use as calcium supplements and help in raktapitta chikitsa.

Some of the shuddha vargiya dravya are as follows: Muktashukti(pearl), Shudha(lime), Godanti(gypsum) and pravala(coral) etc. All these are calcium compounds and are helpful in treating many diseases.

HERBAL REMEDIES BY PLANET AYURVEDA FOR TREATING GLANZMANN THROMBASTHENIA

Planet Ayurveda provides one of the most trusted herbal products and formulations for better treatment of diseases. The positive point of using these drugs is that they have no side effects and they are also Iso-certified herbal products which means these products are tested in the laboratory under various high technologies so that they can be trusted. Planet Ayurveda products do not contain any additives, flavours or preservatives which makes them more trustworthy.

Herbal Remedies for Glanzmanns Thrombasthenia

1. IMMUNE BOOSTER

It consists of many useful ingredients i.e it is used in treating Glanzmann thrombasthenia the main ingredients in it are Grape seed(Vitis vinifera std. ext.), Go-Piyush(Bovine colostrums std. ext.), Bhumi amla(Phyllanthus niruri std. ext.) and Amalaki(Emblica officinalis). In bleeding disorders like Glanzman thrombasthenia in this patient’s immunity is very weak and in this condition, if any other disease occurs it may be the worst condition for the patient. For protecting against any other disease and fighting with this disease.

Dosage: 2 capsules should be taken twice daily after meals

2. GILOY GHAN VATI

Guduchi(Tinospora cordifolia )has many beneficial properties in it which can be helpful in treating autoimmune diseases. It is also helpful in treating diseases like fever, diabetes, anaemia and jaundice etc. it is best to know treating raktapitta due to its rasa (taste) kashaya (astringent) is helpful in stopping the blood. It is also known to be balya(improves strength), dahahara (relieves burning sensation), vayasthapana (anti ageing) etc.

Dosage: 2 tablets should be taken daily two times

3. KUMAR KALYAN RAS

Its main ingredients are Ras sindura (formulation of pure mercury), Shudhha Mukta bhasma (purified pearl), Shuddha Swarna bhasma(purified gold) and Shuddha Loh bhasma (purified iron)etc. As discussed above ayurvedic medicine also mentioned the herbs made up through mineral sources also benefitting in many diseases like bleeding disorders, digestive disorders, cold and cough also they provide immune boosting through their actions.

Dosage: 1 tablet to be chewed daily two times

4. SUVARNA BASANT MALTI RAS

The main ingredients of this formulation are Swarna bhasma (purified gold), Mukta bhasma (pure pearl), Maricha (Piper nigrum) and Gandhak (pure sulphur)etc. This contains zinc and from research, it is stated that it can be helpful in the formation of RBC i.e the reason it can be used in the patient of Raktapitta. This formulation can be given in treating diseases like fever, cold and cough, asthma etc.

Dosage: 1 tablet to be chewed daily after meals two times

5. GREEN ESSENTIALS

It is given to patients for increasing immunity. It has many useful ingredients in it like Grape seed (Vitis Vinifera), Wheatgrass (Triticulum Aestivum), and Spirulina (Spirulina Platensis), Green tea (Camellia Sinensis) and Amla (Embllica Officinalis). The green herbs contain chlorophyll which plays a critical role in increasing the blood oxygen as we know the brain and every tissue works properly if oxygen is sufficiently present.

Dosage: One capsule should be given to the patient twice daily after meals

6. PUNARNAVA MANDUR

This formulation is made up of some beneficial ingredients some of them are listed: Punarnava (Boerhaavia diffusa ), Shunti (Zingiber officinale), Pipali (Piper longum) and Chavya (Piper chaba) etc. It is a very effective iron supplement which is mentioned in Ayurveda Samhitas. The principal ingredient is punarnava which is very effective as an anti-inflammatory, blood purifier and hematinic activities(an agent that tends to increase the production of red cell formation so that increases haemoglobin)

Dosage: 2 tablets twice daily after meals

7. SPIRULINA CAPSULES

Spirulina (Spirulina platensis) capsules are highly recommended sources to increase vitamins, minerals and ions. It is a very wonderful herb for maintaining good health. Spirulina is very rich in specific proteins which are superior to other forms of proteins obtained from plants. It contains essential 22 amino acids which even some legumes are not able to provide. Spirulina therapeutic indications: allergic conditions, cholesterol level maintenance, anti-inflammatory properties and antioxidant properties etc.

Dosage: 2 capsules twice daily after meals

Contact my assistant to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214040 Or Check Website – www.PlanetAyurveda.com

CONCLUSION

In the present era, we will know about many diseases which can not be treated by allopathic medicine and that are not well described in them. In the modern system of medicine whenever they do not find any particular symptoms or particular diagnostic features they get confused.  On another side, ayurvedic medicine is recognised with great results in these diseases. Ayurvedic medicine is nowadays present with evidence-based approaches that are scientifically proven. In Ayurveda, most of the diseases occur due to variations of Vata, pitta and Kapha which are called Doshas. In this disease pitta dosha is imbalanced and to maintain it different herbs can be used which are mentioned in the medicinal textbooks of Ayurveda and they are able to treat well.