Herbal Treatment for SAVI – Sting Associated vasculopathy infancy dependent
Abstract
SAVI that is Sting Associated vasculopathy can be defined as a disorder that causes abnormal inflammation to the entire body especially to the skin, lungs and the blood vessels. This is among the Autoinflammatory diseases. This disorder can also be categorised among the rarely found diseases. It is a hereditary condition found in neonates, this happens mainly due to mutations in the STING1 gene. It is a serious condition that can lead to a lot of systemic disorders. In Ayurveda SAVI is considered to be a Sahaja Roga that means a hereditary condition, this is due to Bija Dosha that is abnormality in the sperm, ova, chromosomes or the genes. This condition is among the rarely found diseases.
Introduction
SAVI or Sting Associated Vasculopathy can be defined as a condition that causes inflammation throughout the body that affects especially the skin, blood vessels and lungs. This change in the body takes place due to mutation in genes that results in over production of inflammatory protein that harms the tissues and also causes inflammation. These genes start producing cytokines that mainly cause this inflammation. This disorder in infants occurs as lesions on the face especially to the nose and ears that can turn into ulcers and lately damages the tissue. This disorder has a higher risk to get into an infant if he or she has a positive family history. Involvement of lungs may be a cause of death in SAVI.
Causes
SAVI is caused mainly due to mutation of genes in STING1 (it physiologically makes a protein called STING) that dysfunctions and over produces. SAVI can be caused either due to a positive family history or may be due to abnormality in the cytoplasm of the tissues.
Signs And Symptoms Of Savi
- Lesions on skin like on fingers, cheeks, toes and soles
- Rashes and blisters on skin
- Stiffness of the joints
- Ulcerations can be found on the skin
- Difficulty in breathing, coughing or other interstitial lung disease (as lungs are affected)
- Nausea and vomiting
- Pain in abdomen
- Swelling and inflammation in hands and feet
- Weakness and fatigue
- Low grade Fever
- Diarrhoea
- Rigidity of joints
- Enlarged lymph nodes
- Dyspnea
- Patients may experience signs of Raynaud’s Phenomenon too
Diagnosis
For diagnosing SAVI following investigations may be required –
- Physical examinations
- Chest X Rays
- Medical history of parents
- CT (Computed Tomography) Scan
- Complete blood count (CBC)
- MRI (Magnetic Resonance Imaging)
- Lung Biopsy
- Skin biopsy
- Genetic Testing
Treatment
In case of treatment of SAVI, symptomatic treatment can be given
- Prevention of target organ damage that is the lungs
- Supportive care to reduce other symptoms like fever, diarrhoea etc
- Corticosteroids
- Immunosuppressants
- Antibiotics to prevent infection
- Anti inflammatories
Complications
- Lost mobility
- Permanent organ damage
- Scarring of the skin
- Chronic inflammation
- Gangrene can occur in tip of toes and fingers
Ayurvedic Aspect Of Sting Associated Vasculopathy Infancy Dependent (Savi)
Ayurveda considers this disorder Sting Associated vasculopathy Infancy Dependent is due to Bija dushti which means abnormality in the ovum or sperm or both. Acharya Charaka says that this abnormality may be due to defects in the chromosome or the genes.
Acharya charaka in (च. शा. ३/१७) says that when vitiation of any dosha causes abnormality to the Beeja bhag (that is the ova or the sperm) it can not work as it would have. And this is what causes the Sahaja Roga or Kulaj Rogas (hereditary disorders). So as the Beeja that is the seed of a new life is formed under abnormal conditions the offspring suffers from several disorders due to imbalance doshas that causes symptoms like stiffness of the joints, lesions or rashes on skin, dyspnea, growth retardation etc.
Treatment
The heredity or the genetic abnormalities cannot be undone or reversed. So Ayurveda does symptomatic treatment for this condition. This supportive treatment can be done to improve the symptoms. Planet Ayurveda has a list of drugs that improves this condition and to restrict further worsening of the symptoms.
Herbal Remedies By Planet Ayurveda For Sting Associated Vasculopathy Infancy Dependent (Savi)
Planet Ayurveda is an established and GMP certified and ISO approved brand that manufactures herbal supplements. Planet Ayurveda had a vision of reaching all over the globe and has achieved that. The raw materials used go through a quality check several times to ensure the use of the best quality product. All the herbal medications by them are 100% vegetarian and are free of adulterants, in fact no fillers or harmful preservatives are used. Planet Ayurveda is dedicated to use the ancient Science of healing Ayurveda to every doorstep. This company exports their products worldwide like to the USA, Europe, Africa and many other countries. All the products by Planet Ayurveda are manufactured following the ancient Ayurvedic texts under the guidance and supervision of experts of Ayurveda. They have plenty of medicines for various other diseases. Listed are few medicines that improve conditions caused due to SAVI.
Product List
- Boswellia Curcumin
- Arvindasav
- Infee Syrup
- Manjishtha Capsules
Description of the products
1. Boswellia Curcumin
Boswellia-Curcumin manufactured by Planet Ayurveda in the form of capsules are made of a combination of two effective herbs Shallaki (𝘉𝘰𝘴𝘸𝘦𝘭𝘭𝘪𝘢 𝘴𝘦𝘳𝘳𝘢𝘵𝘢) and Haridra (𝘊𝘰𝘳𝘤𝘶𝘮𝘪𝘯 𝘭𝘰𝘯𝘨𝘢). It reduces inflammation caused to the blood vessels and due to haridra that has antibacterial properties if heals the ulcers of the skin and shows effective result in discoloration of the skin.
Dosage– 1 capsule twice a day with plain water after meals.
2. Arvindasav
This preparation in the form of syrup has several herbal drugs like khairati(𝘚𝘪𝘥𝘢 𝘤𝘰𝘳𝘥𝘪𝘧𝘰𝘭𝘪𝘢), manjith(𝘙𝘶𝘣𝘪𝘢 𝘰𝘳𝘥𝘪𝘧𝘰𝘭𝘪𝘢), arjun(𝘛𝘦𝘳𝘮𝘪𝘯𝘢𝘭𝘪𝘢 𝘢𝘳𝘫𝘶𝘯𝘢) and various other drugs that pacifies all the three doshas of the body Vata, Pitta and Kapha. Due to the cooling effect of the drugs used in Arvindasav it acts as an antipyretic that is helpful in fever.
Dosage– 10 – 20 ml with equal amount of water, twice or thrice a day after meals.
3. Infee Syrup
This syrup has the goodness of Yashtimadhu (𝘎𝘭𝘺𝘤𝘺𝘳𝘳𝘩𝘪𝘻𝘢 𝘨𝘭𝘢𝘣𝘳𝘢) and Guduchi (𝘛𝘪𝘯𝘰𝘴𝘱𝘰𝘳𝘢 𝘤𝘰𝘳𝘥𝘪𝘧𝘰𝘭𝘪𝘢).This combination helps the infant relieve from weakness or fatigue. It also has properties of an immunomodulator that improves the overall immune system of the body.
Dosage-For Infants – 5-10 drops twice a day with water & For children – ½ – 1 teaspoon a day with water
4. Manjishtha Capsules
These capsules by Planet Ayurveda are made of extract of a single drug Manjishtha (𝘙𝘶𝘣𝘪𝘢 𝘤𝘰𝘳𝘥𝘪𝘧𝘰𝘭𝘪𝘢), this drug is known to improve texture of skin that ultimately helps in symptoms caused by SAVI to the skin. It works predominantly on Pitta dosha and does Rakta shodhana (𝘱𝘶𝘳𝘪𝘧𝘪𝘤𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘣𝘭𝘰𝘰𝘥) that supports healthy skin too.
Dosage– 1- 2 capsules twice a day with plain water after meals
Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4030 (India), +91-172-521-4030 (Outside India) or Whatsapp at (+91) 9915-593-604
Conclusion
Hence we can conclude that this autoinflammatory disorder SAVI (Sting Associated vasculopathy infancy dependent) is a rarely found disease that occurs due to abnormal gene mutation causing inflammation of the entire body and can affect the lungs too that can cause severity. This is a hereditary condition. In ayurveda this condition can be correlated to sahaja rogas which is due to Bija Dosha that is any kind of abnormality in the sperm or the ovum or genes or the chromosomes. In modern Science there are symptomatic treatments for this condition. Planet Ayurveda by following all the ancient scriptures of Ayurveda has a list of above mentioned products that improves this condition.
