Tag: Symptoms of Pigmented Villonodular Synovitis

Pigmented Villonodular Synovitis (PVNS) Treatment In Ayurveda

Pigmented Villonodular Synovitis (PVNS)

Abstract

PVNS (pigmented villonodular synovitis) may be an uncommon form of synovitis that can influence joints all through the body, but most commonly the knees. PVNS is usually categorized as localized or diffuse. It is also called a tenosynovial giant cell tumor when it occurs in a tendon. Although it is often described as a tumor or growth, it is not usually cancerous. But in Ayurveda, there is an effective treatment for Pigmented villonodular synovitis. Now we are going to discuss the cause, symptoms, and treatment of pigmented villonodular synovitis.

Pigmented Villonodular Synovitis (PVNS)

Introduction

Pigmented villonodular synovitis (PVNS) refers to a severe type of synovitis that affects the soft tissues lining the joints and muscles. Pigmented villonodular synovitis usually affects the knee, hip, and ankle and has a poor prognosis, with symptoms occurring years before diagnosis. In addition, Pigmented villonodular synovitis is more aggressive than the other major subtypes of tenosynovial giant cell tumor (tenosynovial giant cell tumor). Pigmented villonodular synovitis is usually categorized as localized or diffuse.

Localised

In localized pigmented villonodular synovitis, the tumor occurs in just one area of the joint or involves the tendons that support the joints. It is easily treatable.

Diffuse

In diffuse pigmented villonodular synovitis, the tumor involves an entire joint, and it is a more widespread condition. It is difficult to treat and is more aggressive.

Causes

Pigmented villonodular synovitis is caused by overgrowth and thickening of the synovial membrane. All movable joints in the body have a synovial membrane that reduces friction in the joint during joint movement. The abnormal synovial lining caused by pigmented villonodular synovitis causes joint swelling, sometimes interferes with movement, and can grow and destroy nearby joints, including large bones.

Symptoms

  • Pain
  • Swelling of the joint
  • Joint effusion
  • Stiffness in the joints
  • Difficulty in walking
  • Locking
  • Instability in the joint
  • Catching

Diagnosis

  • Physical examination
  • X-ray
  • MRI
  • Arthography
  • Joint aspiration
  • Biopsy

Treatment

  • Drug therapy
  • Surgery: synovectomy
  • Radiation

In these treatments, there is a recurrence of tumors and also side effects.

Complications

  • Joint degeneration
  • Bone degeneration
  • Ligament breakdown
  • Tendon breakdown

Ayurvedic Aspect of Pigmented Villonodular Synovitis (Pvns)

In Ayurveda, the symptoms of pigmented villonodular synovitis nearly resemble Kroshtukasheersha. In this disease, mainly the vitiation of vata and rakta is involved.

वातशोणितजः शोफो जानुमध्ये महारुजः।

शिरः क्रोष्टुकपूर्वं तु स्थूल: क्रोष्टुकमूर्धवत।।(सु. नि. १/७६)

According to Acharya Sushruta, when the imbalance of vata and rakta develops swelling and severe pain in the knee joint, that is known as Kroshtukashirsha.

Vata Nidana (Vata Causative Factors)

  • Injury due to fighting
  • Falling down from a certain height
  • Speed walking or running
  • Excessive jumping
  • Excessive physical activity
  • Not sleeping during the night
  • Carrying heavy loads
  • Excessive intake of pungent, astringent, rough, bitter, cold, light, and dry vegetables.
  • Day sleep
  • Fair
  • Excessive fasting
  • Eating during indigestion
  • Intake of large amounts of food and a smaller amount of food at irregular times.

Vata Imbalance Symptoms

  • Tears in bones and joints
  • Stiffness of joints
  • Horripilation
  • Drying of organs
  • Stiffness in hands, back, and head
  • Delirium
  • Sleeplessness
  • Pulsation
  • Numbness in the organs
  • Convulsions
  • Distress
  • Piercing pain
  • Diminished activities
  • Dislocation
  • Pain and discomfort

Treatment of Vata Dushti

  • Snehan (oil application)
  • Sweden (hot sudation)
  • Mridu virechana (mild laxative)
  • Deepan pachana (carminative)

Rakta Nidana (Rakta Causative Factor)

  • Intake of substances that induce a burning sensation inside the body.
  • Excessive exposure to heat and the sun.
  • Excessive consumption of hot, heavy, unctuous, and watery substances.
  • Sleeping during the day.
  • Excessive anger
  • Eating during indigestion
  • Exposure to fire
  • Eating antagonistic foods and taking food during digestion

Symptoms of Vitiated Rakta

  • Burning sensation
  • Reddish discoloration in the eyes, skin, and urine
  • Metabolic joint disorders
  • Discoloration of the skin
  • Loss of digestive fire
  • Excessive anger
  • Suppression of urges
  • Bleeding disorders
  • Fever
  • Excessive thirst
  • Skin related disorders
  • Itching
  • Excessive perspiration
  • Weakness in sense organs

Treatment of Rakta Dushti

  • Raktamokshan (Bloodletting therapy)
  • Fasting therapy
  • Purgation
  • Raktashodhak (Blood purification)

Some Herbal Remedies for Pigmented Villonodular Synovitis by Planet Ayurveda

Planet Ayurveda is a registered Ayurvedic company that formulates various supplements for the treatment of disease. The formulations produced by Planet Ayurveda are free of any preservatives and various chemicals that do not cause any side effects on the human body. The products manufactured by Planet Ayurveda are pure and free of any adulteration. These products are pure, gluten-free. And for pigmented villonodular synovitis, Planet Ayurveda has created various supplements that are beneficial.

Product List

  • Boswellia Curcumin
  • Joint Aid Plus
  • Lakshadi Guggul
  • Kanchnaar Guggul
  • Kamdudha Ras Moti Yukt

Herbal-Remedies-for-Pigmented-Villonodular-SynovitisAyurvedic Management of Pigmented Villonodular Synovitis

Products Description

1. Boswellia Curcumin

Boswellia curcumin is a polyherbal formulation that is formulated by Planet Ayurveda using Haridra (Curcuma longa) and Shallaki (Boswellia serrata). The combination of Shallaki (Boswellia serrata) and Curcumin (Curcuma longa) helps reduce pain and has synergistic effects. In this, shallaki acts as an anti-inflammatory herb, and curcumin acts as an antioxidant.

Dosage: with plain water, after meals, 2 capsules twice daily.

2. Joint Aid Plus

Joint Aid Plus is a polyherbal capsule that is formulated by Planet Ayurveda by using Shallaki (Boswellia serrata), Nirgundi (Vitex negundo), Guggul (Commiphora mukul), Sonth (Zingiber officinale), and Ashwagandha (Withania somnifera). In this formulation, ashwagandha (Withania somnifera) helps provide strength to the ligaments and muscles. Shallaki (Boswellia serrata) acts as a painkiller and anti-inflammatory herb, and sonth (Zingiber officinale) is helpful in digestion and also gives pain relief.

Dosage: with plain water, after meals, 1 capsule twice daily.

3. Lakshadi Guggul

Lakshadi guggul is a polyherbal tablet that is formulated by Planet Ayurveda by using Asthisamharaka (Cissus quadrangularis), Laksha (Laccifer lacca), Ashwagandha (Withania somnifera), Arjuna (Terminalia arjuna), Shuddha guggulu (Purified Commiphora mukul), and Nagabala (Grewia populifolia). It helps soothe the ligaments and enhance bone density. In this formulation, ashwagandha and shuddha guggulu help reduce pain by pacifying the vata dosha.

Dosage: with lukewarm water, after meals, 2 tablets twice daily.

4. Kanchnaar Guggul

Kanchnaar Guggul is a polyherbal formulation that is made by Planet Ayurveda using various ingredients Kachnar Bark (Bauhinia variegata), Amalaki (Emblica officinalis), Tejapatra (Cinnamomum tamala), Haritaki (Terminalia chebula), Bibhitaki (Terminalia bellerica), Varuna Bark (Crataeva religiosa), and many more. These tablets have anti-inflammatory properties and are helpful in promoting healthy functions of the body and controlling excessive weight. It is effective for pain, and it contains magnesium, calcium, iron, vitamin B, vitamin C, proteins, and dietary fibers.

Dosage: with lukewarm water, 2 tablets twice daily.

5. Kamdudha Ras Moti Yukt

Kamdudha ras moti yukt is a polyherbal formulation that is formulated by Planet Ayurveda using Mukta bhasma (Pearl calx), Shankh bhasma (Conch shell ash), Praval bhasma (Coral calx), Giloy satva, and some other ingredients. It acts as an anti-inflammatory, an antipyretic, a blood purifier, an anti-arthritic, an antiemetic, etc. It helps in decreasing the heat level of the body.

Dosage: with plain water, 2 pills twice daily.

Contact Planet Ayurveda Support Team to provide you the costing/ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 9915-593-604

Conclusion

PVNS (pigmented villonodular synovitis) may be an uncommon form of synovitis that can influence joints all through the body, but most commonly the knees. PVNS is usually categorized as localized or diffuse. Pigmented villonodular synovitis (PVNS) refers to a severe type of synovitis that affects the soft tissues lining the joints and muscles. Pigmented villonodular synovitis usually affects the knee, hip, and ankle and has a poor prognosis, with symptoms occurring years before diagnosis. In Ayurveda, the symptoms of pigmented villonodular synovitis nearly resemble Kroshtukasheersha. In this disease, mainly the vitiation of vata and rakta is involved. In Planet Ayurveda, there are some herbal remedies that give effective results in pigmented villonodular synovitis without causing any side effects.

Pigmented Villonodular Synovitis – Symptoms, Causes and Ayurvedic Treatment

Abstract

This curious condition of uncertain nature can be best characterized as a proliferative lesion of joints and tendon sheaths, marked by hemosiderin deposition within villous overgrowths of synovium. The synovial overgrowth may be sufficient to induce tumor-like masses which project into the joint or tendon sheath spaces. Indeed, as will be seen, one view holds that this lesion is basically neoplastic. It occurs as a localized process in tendon sheaths, but in joints the entire synovial lining is usually involved, particularly in the knee and less often the hip. Occasionally, lesions are found in periarticular tissues, presumably arising within sub-synovial connective tissue. Females tend to be affected slightly more often than males. Frequently, it leads to effusions into the joint spaces or tendon sheaths, accompanied by pain, swelling, and sometimes locking of the joint. Only the knee is involved in 80% of patients. It occurs usually in adults between 20-50 years of age.  Today we will read about pigmented villonodular synovitis in brief in this article.

Introduction

Pigmented villonodular synovitis is a progressive condition in which proliferative lesions of joints and tendon sheaths are caused due to overgrowth of synovium. The mass is non cancerous and does not metastasize to other body parts. Grossly, the lesion in tendon sheaths takes the form of a small, ovoid swelling, rarely greater than 3 cm in diameter which on transection is usually golden-yellow to red-brown, depending on the amount of contained lipid and hemosiderin. In joint spaces, more or less of the entire synovial lining is transformed into a tangled mat by numerous sessile or villous projections. Sometimes discrete, yellow-brown nodules having the appearance of neoplasms develop either within the thickened synovial membrane or as pedunculated lesions

Cause

  • The exact cause is unknown. It can be caused by CSF1 gene over-expression.
  • Genetic mutations of chromosome 1p13 and rearrangement of 5q33 chromosomal.
  • Associated conditions like giant cell tumors of tendon sheath.

Pathogenesis

The pathogenesis of this lesion is completely obscure. It has been viewed variously as:-

  1. A neoplastic process
  2. As inflammatory in origin, although no specific agents been isolated
  3. As a localized disturbance of lipid metabolism leading to accumulation of lipids within phagocytic cells with secondary traumatic changes
  4. As an obscure overgrowth of synovial and peri synovial cells.

The fact that the lesion frequently recurs following incomplete excision has been taken as evidence for a neoplastic origin, but such behavior does not rule out other possible origins. We must leave it that this disabling but not life threatening condition is still a complete enigma.

Symptoms of Pigmented Villonodular Synovitis

Symptoms

  • Swelling and pain in joints which are affected
  • Locking of the joint
  • Stiffness in joints

Diagnosis

  • Physical examination:- Inspection of joints to check  joint effusion, erythema, tenderness and motion of affected joint.
  • X-ray:- It may show periarticular mass, soft tissue swelling and cystic erosion of joints.
  • Magnetic resonance imaging:-  It shows excellent pictures of delineation of both extra-articular and intra-articular disease.

Treatment

  • Medical:- Use of CSF-1 receptor antagonist
  • Surgery:- Partial synovectomy/complete synovectomy is done.

Ayurvedic overview

In ayurveda, pigmented villonodular synovitis’s symptoms nearly resemble Kroshtukasheersha which is described in sushruta samhita nidansthana vatavyadhi chapter shloka 76. In this disease mainly vata and rakta are involved.

वातशोणितज: शोफो जानुमध्ये महारुज:। 

शिर:क्रोष्टुकपूर्वं तु स्थूल: क्रोष्टुकमूर्धवत ।।  (सु. सं .नि .1/76)  

According to the above shloka:- In knee joint vikriti (imbalance) of vaat and rakta develop severe pain and swelling which is known as Kroshtukasheersha.

Vata dosha gets aggravated with above mentioned factors which lead to occupied vacant channels. On filling the vacant spaces, the aggravated vata develops many diseases like it may be limited to a particular area or affecting the whole body that is vatavyadhi.

Treatment

  1. Raktamokshana (blood letting therapy):- In this therapy impure blood is expelled out from the body by using horns, leech, multiple pricking, gourds etc.
  2. Purgation:- This therapy is done by herbs in which toxins are expelled out from the body.
  3. Fasting therapy:- It brings lightness in the body.
  4. Raktashoshan (blood purification)

There are various herbs which purifies the blood including

  • Neem:- This is bitter and astringent in taste. It is always kapha and pitta but aggravates vata. It is light and cold in effect. Due to these properties it purifies the blood and prevents skin from acne, pimples, allergies, etc. It reduces the toxin level in the body.
  • Turmeric:- It contains bitter and pungent properties. It is light, dry and hot in effect. It is helpful in blood formation along with blood purification.
  • Manjishtha:- It is bitter and astringent and sweet in taste. It is heavy, dry and hot in effect but it is a pacifier of kapha and pitta. It helps to gain lusture and glow to the skin and aids to remove pimples, freckles and discoloration. It also promotes the healing of skin tissues damaged by injury or infection.
  • Daruharidra:- It is bitter and astringent, light, dry and hot in effect. It reduces inflammation and pain. It is a wound healer.

Herbal remedies for pigmented villonodular synovitis by planet ayurveda

Planet ayurveda provides various ayurvedic medicines for different kinds of diseases. They made various types of formulation by following all the principles of ayurveda in ancient textbooks. These ayurvedic medicines are GMP certified and are safe for the human body. All the formulations are made from pure herbs which are highly effective in the human body and free from harmful chemicals, preservatives, yeast or additives. Planet ayurveda provide herbal remedies for pigmented villonodular synovitis:-

  1. BOSWELLIA+CURCUMIN
  2. JOINT AID PLUS
  3. LAKSHADI GUGGUL
  4. KANCHNAAR GUGGUL
  5. KAMDUDHA RAS (MOTI YUKT)

Herbal Remedies for Pigmented Villonodular Synovitis

Ayurvedic Management of Pigmented Villonodular Synovitis

Product Description

1. Boswellia+curcumin

It is a poly herbal capsule made from shallaki (Boswellia serrata) and haridra (curcuma longa). Boswellia have anti-inflammatory features which stop the cytokines secretion and reduce inflammation or swelling. Curcuma longa has an antioxidant property which protects brain neurons and reduces the wrinkles on skin. It purifies the blood and helps in blood formation in the body. It also applies on cuts and bruises because it is a natural antibiotic. It prevents colon and skin tumors. It is known as antibacterial, anti-allergic, carminative and diuretic medicine. It is an effective remedy for sprains, wounds and inflamed joints.

DOSE:-2 capsule twice daily, after meals with plain water.

2. Joint aid plus

It is a polyherbal capsule formed from nirgundi (vitex negundo), shallaki (boswellia serrata), guggul (commiphora mukul), etc. It is bitter in taste but hot in effect. It has qualities to pacify all three doshas in the body (vata, pitta and kapha). It is light, dry, sharp and unctuous. It contains calcium, magnesium, iron and silicon dioxide. It is a very potent medicine for various types of joint problems such as rheumatoid arthritis, osteo arthritis and gout. It helps in reducing pain, swelling and tenderness of the inflamed joints. It has anti-hypercholesterolemic properties. It lowers serum triglycerides and cholesterol levels. It is an antioxidant and immune-modulator. It prevents all types of weakness and increases one’s strength and stamina. It induces sound sleep.

DOSE:- 1 Capsule twice daily

3. Lakshadi guggul

It is a herbal tablet made from laksha (laccifer lacca), arjuna (terminalia arjuna), ashwagandha (withania somnifera), etc. It is bitter and astringent in taste. It is dry, cold and light in effect. It is also a pacifier of kapha and pitta. It contains calcium, magnesium, aluminium etc. it is healer of wounds, antibacterial, antifungal and antipyretic. It is beneficial for heart diseases. It helps in excessive palpitation due to anxiety. It helps bones to regain strength after fractures. It contains anti-anginal properties. It is anti inflammatory as well anti-lipemic.

DOSE:– 2 tablets twice with lukewarm water

4. Kanchanaar guggul

It is a herbal tablet which is formed from kanchanar bark (bauhinia variegata), amalaki (emblica offinalis), haritaki (terminalia chebula), etc. It is bitter and astringent in taste but hot in effect. It has a strong antioxidant which reduces toxins from the body. It contains magnesium, calcium, vitamin B, iron, vitamin C, proteins and dietary fibre. It is effective in relieving pain. It reduces swelling and stiffness of joints. It helps in purification of blood and regulates the level of cholesterol. It improves the menstrual cycle in females.

DOSE:- 2 tablets twice daily with lukewarm water

5. Kamdudha ras (Moti yukt)

It is a classical ayurvedic pills made from giloy satva (tinospora cordifolia), mukta shukti bhasma (pearl oyster), shuddha gairik (red oxide of iron), etc. It pacifies all the three doshas. It is cold in effect. It acts as an anti inflammatory, antipyretic, anti arthritic, a blood purifier, antacid, antiemetic, etc. It decreases the heat level in the body and balances the production of acid in the stomach and decreases the inflammation of the organs. It is helpful in nausea, vomiting, and improving appetite. It inhibits gastric ulcers. It helps in treating white discharge from vagina in females. It is a rejuvenator and a restorative tonic.

DOSE:- 2 Pills twice daily

Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4030 (India), +91-172-521-4030 (Outside India) or Whatsapp at (+91) 9915-593-604

Conclusion

Pigmented villonodular synovitis is a progressive condition in which proliferative lesions of joints and tendon sheaths are caused due to overgrowth of synovium. In ayurveda it is caused by vitiation of  vata and rakta. In ayurveda we can manage this condition by various methods like blood purification by leech, horns etc. and by herbs like curcuma longa, neem, manjistha, daruharidra, etc.