What is GNE MYOPATHY? – Causes, Diagnosis & Ayurvedic Treatment


GNE myopathy is a hereditary illness that mostly affects the skeletal muscles. It is also known as HIBM, Nonaka myopathy, IBM2, and distal myopathy with rimmed vacuoles. The disease’s earliest symptoms develop between the ages of 20 and 40, and it affects both men and women at the same rate. Progressive muscular weakness, which often increases over time, decreasing grip strength, and frequent loss of balance are all symptoms of this illness. There is currently no cure for the condition, and therapy focuses on symptom management. Ayurveda, on the other hand, may aid in the management of this ailment.


GNE myopathy is a hereditary muscle disorder in which GNE refers to the defective gene. It is a rare condition that affects around one person in a million individuals throughout the globe. It causes muscle weakness and atrophy in the legs and arms. The beginning of symptoms is generally in young adults, however, some people have seen a later onset. Foot drop is generally associated with increased tripping and a steppage gait at first. The problem worsens with time, resulting in proximal leg muscular weakness, difficulty ascending stairs or rising from a seated position and weakening of the hands and shoulder muscles.

How an you recognize myopathy’s indications and symptoms?

  • Disturbed gait and impaired stability are common in GNE myopathy patients, as are frequent falls, difficulties ascending stairs, jogging, and getting up from a sitting posture.
  • The muscles of the lower limbs are the first to be damaged, with the exception of the quadriceps, which seem to be largely unaffected.
  • Neck muscles might be impacted in the latter stages of the illness.
  • Finally, as the illness progresses, skeletal muscle function may be lost completely, leaving the patient completely reliant on others.

Acquired myopathies may exhibit symptoms that are comparable to hereditary myopathies, as well as the following

  • Muscle deterioration
  • Motor sluggishness
  • Impairment of the respiratory system
  • Dysfunction of the bulbar muscles (malfunction of the muscles responsible for swallowing and speech)

Causes of GNE myopathy


Changes (mutations) in the GNE gene, which codes for the enzyme glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, cause GNE myopathy. Infection, muscular damage, medicines, electrolyte imbalances, and thyroid illness are among the other reasons.


GNE myopathy testing is appropriate for patients who have foot drop (in young adults) and distal extremity muscle weakness (in those who have advanced stages of the illness). Genetic testing is an excellent initial step in determining the severity of GNE myopathy in individuals. This includes the use of minimum or no invasive treatments, simply requiring a blood or saliva sample, and yielding results in hours or days.

Factors at Risk

Some myopathies, such as some forms of muscular dystrophy, are hereditary. Other myopathy risk factors include:

  • Myasthenia gravis, scleroderma, and thyroiditis are examples of autoimmune diseases.
  • Endocrine problems
  • Toxin exposure, such as pesticides and flame-retardant chemicals
  • Infections
  • Deficiency in vitamins
  • Antihistamines and long-term corticosteroids are among the drugs used.
  • Glycogen and lipid storage disorders are examples of metabolic diseases.

Treatment with Ayurveda

It is considered an incurable myopathy, with mortality occurring between the ages of 20 and 25. Modern science has limits in treating the ailment, but Ayurveda has a lot of promise in treating diseases that are incurable. Ayurveda may assist in maintaining a healthy range of motion for all of the body’s joints. Toxins are removed from the body, the doshas are balanced, and the body cells and muscles are rejuvenated to promote strength and flexibility. Yoga and meditation sessions are used in addition to treatment methods to increase blood circulation to all body parts and joints. These reduce the likelihood of acquiring additional medical problems while also enhancing respiration and other critical bodily processes.

A healthy food plan is also arranged for optimal nourishment that assists in muscle growth as well as overall body development. A well-balanced diet may assist to soothe inflamed doshas and bring the body’s critical systems and hormone levels back into equilibrium. Herbal decoctions for internal ingestion are given in addition to therapy regimens to assist ease symptoms. And that’s what the world’s leading Ayurveda industry, Planet Ayurveda offers us.

Description of the product

1. Ashwagandha Ghrit

It’s great for muscular fatigue, stiffness in the neck or back, exhaustion, joint problems, and arthritis of any kind. It also helps with anxiety, tension, and depression. The main ingredient of this formulation includes Ashwagandha (Withania somnifera).

Dosage: 1 tsp twice a day in warm water

2. Musli Strength

Safed Musli (Chlorophytum borivilianum) and Gokshura (Tribulus terrestris) are used in this herbal medicine. It aids in the enhancement of growth hormone circulation in the blood. This also aids in the development of muscle growth and strengthening to help in reducing GNE myopathy effects.

Dosage: 1 capsule twice a day

3. Boswellia Curcumin

Boswellia Curcumin seems to be helpful in lowering inflammation, alleviating arthritis symptoms, and increasing muscular strength. Shallaki (Boswellia serrata) and Curcumin (curcuma longa) are the main ingredients in this herbal combination that can help to get relief from GNE myopathy.

Dosage: 2 capsules twice a day

4. Yogaraj Guggul

Yograj Guggulu contains herbs including Chitraka (Plumbago zeylanica), Shuddha Guggulu (Commiphora mukul), Ardraka (Zingiber officinale), Pippali (Piper longum), Haritaki (Terminalia chebula), and others that may help reduce pain and enhance joint and muscular mobility, which following useful to get rid from GNE myopathy.

Dosage: Take 2 tablets  twice a day

5. Atirasadi Churna

Gokshura (Tribulus terrestris), Ashwagandha (Withania somnifera), Nutmeg, Shatavari (Asparagus racemosus), Kali Musli (Curculigo orchioides), Safed Musli (Chlorophytum borivilianum), and Varahi Kand (Dioscorea bulbifera) are some of the components in Planet Ayurveda’s Atirasadi Churna. It primarily aids in the development of stamina, and the strengthening of weak muscles. Moreover, it helps in the reduction of tension, and the reduction of worry.

Dosage: 1 tsp twice a day with warm milk is the recommended dosage.

6. RasRaj Ras

It is an Ayurvedic medication for neuromuscular diseases, as well as nerve and muscle strengthening. Ashwagandha Churna (Withania somnifera), Rasa sindura (purified and processed Mercury), Swarna Bhasma (Gold Bhasma), Loha Bhasma (Iron Bhasma), Rajata Bhasma (Silver Bhasma), and Vanga Bhasma (Tin Bhasma) are some of the herbs found in it.

Dosage: 1 chewable tablet once a day.

7. Bala Ashwagandha Oil

The oil’s rejuvenating effects help muscles to relax, nerves to tone, and nerve conduction to improve. It is used to relax the muscles while gently stroking them.

Dosage: For external use only.

Contact my assistant to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214040 Or Check Website – www.PlanetAyurveda.com


The negative effects of long-term allopathic medicines and therapies that produce GNE Myopathy might be addressed with these herbal combinations. As a result of the inefficacy of allopathic therapy. Start with Planet Ayurveda to purchase a real Ayurveda product if you want to learn more about the therapy. They may be reached at herbalremedies123@yahoo.com or their clinic in Mohali, Punjab.

Dr. Vikram Chauhan


Dr. Vikram Chauhan (MD - Ayurveda) is the CEO and Founder of Planet Ayurveda Pvt. Ltd. He is Author of the Book "Ayurveda – God’s Manual For Healing". He is an Ayurveda Expert Serving People worldwide through all the Possible Mediums, Operating from Main Branch in Mohali, India. With his Vast Experience in Herbs and their Applied Uses, he is successfully treating Numerous Patients suffering from Various Ailments with the help of Purest Herbal Supplements, Diet, and Lifestyle, according to the Principles of Ayurveda. For More Details, visit www.PlanetAyurveda.com.

View more posts from this author

Leave a Reply

Your email address will not be published. Required fields are marked *