Category: Depression

Fragile X Syndrome (Martin-Bell syndrome)-Treatment in Ayurveda


Genetic disorders are the disorders that occur due to changes or mutation in the genes. These mutations occur at the time of conception. There are many disorders that fall in the category of genetic disorders. Further in the scenario comes the developmental disorders that may result due to poor nutrition intake by mother lead to hampered development of the bodily organs. Hence when such an underdeveloped organ’s child is born then some unwanted and unavoidable things happen that affect the life standard of that person drastically. In other words, the person becomes dependent on others. These changes can alter the life from mild to severe depending on the degree of development error. In the text below, we are going to discuss one such condition namely Fragile X Syndrome. Let’s get started !!

Fragile X Syndrome, (Martin-Bell syndrome)


Fragile X Syndrome is a genetic disorder that results in a number of developmental problems including learning incapacities, cognitive impairment and mental debilitation. Typically, males are more seriously affected by this condition than females. The condition is named as Escalante syndrome. Fragile X Syndrome causes a lot of symptoms other than the neurological ones. The face features are also layered than the normal one. The Fragile X Syndrome occurs in approximately 1 in 4000 males and 1 in 8000 females. In Ayurveda, the condition can be correlated with beej dushti by the vitiated vata dosha. We will look deep into the Ayurvedic aspect of the same. For now let’s have a look at the causes, signs, symptoms, investigations and management of Fragile X Syndrome !!

Causes of Fragile X Syndrome

Mutations in the FMR1 gene cause fragile X syndrome. This FMR1 gene gives directions to making a protein called FMRP. Thus protein manages the production of different proteins and assumes a part in the development of synapses which are specific associations between nerve cells. Neural connections or synapses are basic for relaying impulses.

The DNA segment, called as CGG triplet repeat. Generally this segment is repeated from five to forty times but in Fragile X Syndrome this is repeated more than two hundred times. This abnormal expansion of the CGG segment silences the FMR1 gene that hampers the production of FMRP. Shortage of the protein results in various abnormal functioning of the nervous system and signs and symptoms of fragile X syndrome appear.

Signs and symptoms

Younger ones do not show any physical signs or symptoms of fragile X syndrome. The physical features do not appear until puberty.

Physical appearance

  • Long face
  • High arched palate
  • Flat feet
  • Hyperextensible finger joints
  • Hyperextensible thumbs
  • Soft skin
  • Hypotonia
  • Large and protruding ears
  • Post Pubescent macroorchidism


Intelligent quotient can vary from normal to severely disabled with an average 40 IQ in males with total silencing of the FMR1 gene. Females who are not affected much as compared to males have generally normal levels of IQ. The main problems that a person with fragile X syndrome faces short term memory, visual memory, mathematics, visual spatial relationships and executive function.


In many cases, Fragile X Syndrome coexists with autism and it is one of the suspected genetic causes of autism.

Genetic mouse models of fragile X syndrome have also presented to behaviour like autism.

Social interaction

Fragile X Syndrome is characterised by poor eye contact, prolonged time to interact with people, difficult and prolonged challenges forming peer relationships, gaze aversion and social anxiety. Excessive shyness, panic attacks.

Mental health

Majority of males and thirty percent females suffering from Fragile X Syndrome have Attention deficit hyperactivity disorder (ADHD). Children suffering with fragile X syndrome are hyperactive, have a very short attention span, and are hypersensitive to tactile, auditory, olfactory and visual stimuli. Preservation is one of the common behavioural and communicative symptoms of fragile X syndrome. Overdoing or repeatedly doing an activity.
Persons with fragile X syndrome experience mood disorders, anxiety issues, and dementia.

Ophthalmologic symptoms

Strabismus is one of the ophthalmological manifestations of fragile X syndrome. Amblyopia and refractive errors are common is fragile X syndrome.

Neurological symptoms

Seizures, tremors and loss of coordination is seen in the persons suffering with Fragile X Syndrome.

Fertility and working memory

Fertility and working memory in persons with fragile X syndrome is severely hampered.


    • Polymerase chain reactions (PCR)
    • Southern blot
    • Prenatal testing with chorionic villus

sampling or amniocentesis appears to be reliable.


  • Symptomatic management is done with much use of stimulants that manages impulsivity, attentional problems and hyperactivity.
  • Underlying anxiety, depression, obsessive compulsive behaviours and mood disorders are managed with antidepressants such as selective serotonin reuptake inhibitors (SSRIs)
  • To manage aggression, aberrant and self injurious behaviours are managed by antipsychotics.
  • Seizures and mood swings are managed by anticonvulsants.

Ayurvedic Aspect of Fragile X Syndrome and its Management

Ayurveda is a traditional medicinal system of India. Ayurveda has been serving mankind since ages and the principles of Ayurveda are still valid till date. Ayurveda is based on the three doshas (energies) vata, pitta and kapha. Theses within the normal range pronounced as health wheres any imbalance is regarded as a state of a disease. Furthermore Ayurveda focuses on the way of life or type of lifestyle. As Ayurveda considers the sedentary lifestyle a root cause of various diseases. Ayurveda has mentioned about the anuvanshik roga (genetic disorders).

In the case of Fragile X Syndrome, the Ayurvedic concept of beej dushti comes out to be the perfect correlation. When the shonit (ovum) and shukra (sperm) get vitiated by any or two or all three dosha at the time of fertilisation, then it gives rise to the establishment of the dusht beej that in later life results in the diseased or abnormal child. This is the best correlation that can be well established with Fragile X Syndrome.

As the basic structure of a person or the beej dushti cannot be reversed. Therefore, the management of Fragile x Syndrome becomes completely symptomatic. The symptoms of the condition can be well managed with the Ayurvedic medicines with the dosha pacification properties. Generally the symptoms that appear in fragile X syndrome are due to vata imbalance. The management thus depends on balancing the vata dosha and other associated dosha involvement.

Certain medications such as vat vidhwansan ras, vrihat vatchintamani ras, vat gajankush ras, haridra khand, ras sindoor, brahmi vati, shankhpushpi powder, yashthimadhu ghan vati, ashwagandharishta, kumar kalyan ras etc are helpful in managing fragile X syndrome up to a desired level.

Herbal Remedies by Planet Ayurveda for Fragile X Syndrome

Planet Ayurveda is an eminent ISO 9001:2015, USA-FDA, GMP certified ayurvedic company. Planet Ayurveda looks forward to spreading the wisdom of Ayurveda on the Planet Earth. Planet Ayurveda formulates formulations that are available in various forms such as tablets (vati), capsules, jams (avleha/prash), powders (churna), syrups (asavarishta/ark/saar). The products of Planet Ayurveda are pure and do not contain the harmful chemicals. Products are not mixed with additives and flavour enhancers. Planet Ayurveda’s products are halal certified and gluten free. Planet Ayurveda extends its products for the management of Fragile X syndrome.

Following are the products of Planet Ayurveda that are helpful in managing Fragile X Syndrome

  1. Ashwagandhadi Ghrit
  2. Kumar Kalyan Ras
  3. Telomere Boostup
  4. Brahmi Vati Gold
  5. Vat Gajankush Ras
  6. Curcumin 95% Capsules

Herbal Remedies for Fragile X SyndromeHerbal Remedies for Fragile X Syndrome

Product description


Ashwagandhadi Ghrit is one of the classical ayurvedic formulations used to manage a number of conditions. Ashwagandhadi Ghrit is composed of ashwagandha (Withania somnifera), bibhitaki (Terminalia bellirica), cow’s ghee (clarified butter) and cow milk. Ashwagandha is regarded as rasayana. Therefore, Ashwagandha helps in a variety of conditions from general debility to chronic conditions. Ashwagandha pacifies the vata dosha and thus improves functioning of the neurological disorders. Ashwagandhadi Ghrit manages symptoms of Fragile X Syndrome very well with its antiepileptic, antipsychotic, anticonvulsant and antidepressant activities.

Dosage: Half tsp twice daily


Kumar Kalyan Ras is a classical herbomineral formulation that is used in a very large variety of disorders. Kumar Kalyan Ras is made up of kumari rasa (Aloe vera juice), ras sindoor (purified mercury), mukta bhasma (pearl calx), swarna bhasma (gold calx), abhrak bhasma (mica calx) and various others. Kumar Kalyan Ras works as an elixir in paediatric disorders. It helps in various disorders of children and multiplies the potency of the other medicines with which it is taken. Kumar Kalyan Ras pacifies the pitta dosha which helps in coping up with impulsivity, hyperactivity and aggression of Fragile X Syndrome.

Dosage: One tablet twice daily


Telomere Boostup is a patent product of Planet Ayurveda. Telomere Boostup is filled with the energy providing an immunity building properties of ashwagandha (Withania somnifera), grapeseed (Vitis vinifera), amla (Emblica officinalis), moringa (Commiphora mukul) and giloy (Tinospora cordifolia). All these herbs boost immunity and aid proper spermatogenesis and oogenesis and prevent further passing on the affected genes to the offspring. Furthermore, it helps in overall mental and physical soundness of a person with Fragile X Syndrome.

Dosage: One capsule twice daily.


Brahmi Vati Gold is a classical herbomineral formulation that is used for a wide variety of psychological, psychiatric and neurological disorders. Brahmi vati is composed of different herbs such as brahmi (Bacopa monnieri), vacha (Acorus calamus), swarna bhasma (calx of gold) etc. The ingredients of the formulation are very effective in the management of various vata and pitta disorders. As depression, suicidal thoughts, self harm, mania, aggression, tremors, seizures etc are due to vata and pitta related, Brahmi vati Gold is perfect remedy to manage all these very well. Therefore, Brahmi Vati Gold is one of the finest remedies for Fragile X Syndrome.

Dosage: One tablet once daily.


Vat Gajankush Ras is a classical herbomineral formulation that is extensively used in vat disorders and vata and kapha symptoms. Vat Gajankush Ras is made up of shudha parada (purified mercury), loha bhasma (Calx of Iron), makshik bhasma (Calx of iron pyrite and copper), shudha gandhak (purified sulphur), black pepper (Piper nigrum), long pepper (Piper longum), shunthi (Zingiber officinale) and various other herbs and minerals. Vat Gajankush Ras is a well known remedy for vata disorders. Psychosis and depression are due to vata vitiation and the condition is thus required to be managed by vat pacification and there is no better remedy than Vat Gajankush Ras.

Dosage: One tablet twice daily


Curcumin 95% capsules are a patent product of Planet Ayurveda. Curcumin 95% capsules contain pure herbal extract of haridra (Curcuma longa). Turmeric being a vata dosha balancer helps in the healthy functioning of the nervous system. Haridra is used to calm the mind and results in well being of mental health. As it balances the vata dosha, it is of great use in the management of mental illnesses like depression and anxiety lead by Fragile X Syndrome.
Dosage: One capsule twice a day.

Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – or Call at 0172-521-4030 (India), +91-172-521-4030 (Outside India) or Whatsapp at (+91) 9915-593-604


Fragile X Syndrome is a genetic disorder that makes a person (child) physically abnormal and mentally disabled. This is a threatening condition that occurs due to over repetition of segment CGG that silences the FMR1 gene and the condition progresses and hampers the intellectuality of a person. Amid the intellectual abnormality the physical appearance of the affected person is also deranged as the silencing of FMR1 gene results in the hampering of the protein FMRP and other proteins as well. Hence the condition is disabling.

The management of the condition is generally symptomatic and the modern medicines are quite toxic and hampers the functioning of other healthy organs and the condition can be seriously deteriorated. Whereas the Ayurvedic medicines check the intellectuality levels and uplift it. And the prevent the tremors and epilepsy attacks with vata balancing properties and with their pitta balancing properties they effectively mangoes the aggression and self harm or suicidal thoughts without any side effects on the body. Hence the herbal or Ayurvedic management of Fragile X Syndrome seems positive and devoid of any side effects.

Hypokalemic Periodic Paralysis Treatment By Herbal Remedies


Hypokalemic periodic paralysis is a genetic condition that is associated with muscle weakness and paralysis. Genetic condition comes into context when someone inherits an altered gene from their parents and there is an increase in developing that particular condition too in them. Genes are the proteins in the body that play an important role in transferring any kind of information in the body that is needed to control the body’s growth, development and functioning. So if there is a defect in any of the genes then the definite thing is to develop any condition in the body. Many conditions run into the families and one of them is Hypokalemic Periodic Paralysis. Now we are going to discuss in this article about this condition in detail and the management of this particular condition with the help of ayurvedic remedies.

Hypokalemic Periodic Paralysis


Hypokalemic periodic paralysis, a condition associated with low levels of potassium and includes episodes of severe muscle weakness that generally begins in childhood or at the adolescent age. Mostly these episodes include temporary inability in moving muscles of the arms and legs. There are several attacks almost every day. Particularly this condition occurs rarely but is considered as very severe in nature. Although the exact prevalence of this condition is unknown, hypokalemic periodic paralysis has an estimate to affect 1 in 100,000 people. Men are more prone to experience the symptoms of Hypokalemic periodic paralysis than women. To know more let’s study the causes and symptoms of Hypokalemic periodic paralysis.


It is one of the genetic disorders in which there is a mutation in the gene named CACNA1S and SCN4A. These are the essential genes that provide command for making proteins which play an important role in the skeletal muscles for maintaining their functions. The normal movement of the body is conducted by contraction and relaxation of the skeletal muscles in a coordinated way. The contraction of the muscles are activated by flow of some positively charged ions in the muscle cells. Both the previously mentioned genes form channels which control the flow of that positively charged ions. The CACNA1S transports the calcium ions and the channels of SCN4A helps in transporting the sodium ions. If the mutation occurs in both the genes they alter the functioning and structure of sodium and calcium channels. Thus causes alteration in the contraction of the skeletal muscles which alters the movement of the muscles and leads to the severe muscle weakness and paralysis in episodic periods which is known as hypokalemic periodic paralysis.


As it is a genetic disorder the one who suffered from this condition may experience the symptoms at the age of 10-14 years. The periods occur randomly and get more triggered by some factors like exercise, food items etc. After waking from sling time sleep it’s very habitual to experience. The severity of the attacks vary from forbearing muscle weakness to remarkable paralysis. The episodes may last between several hours to several days and their frequency also varies from human to human. Some of the humans may experience the episodes daily and some may experience a few times a year. With the growing age the episodes of paralysis become fewer and are known as abortive attacks which refers to general weakness that lasts for a longer period of time. Beside all this one may experience the following symptoms:

  • Weakness in muscles
  • Cramping in muscles
  • Heart palpitations
  • Most oftenly the muscles involved are shoulders, arms, legs and hips
  • Paralysis


This condition is even hard to diagnose as there is not such specific test for this condition. Also we cannot diagnose this condition with the symptoms rather the attack will occur. So if any of you may experience the significant symptoms of Hypokalemic periodic paralysis then it’s a must to visit the physician nearby. The physician will ask you your symptoms, at which time you may experience the symptoms and after that the diagnosis may be clear but it’s difficult to diagnose. If someone have family history then the diagnosis is more clear and at the time of diagnosis if someone experience symptoms then the following diagnostic techniques may be done to clarify the diagnosis:

  • Blood tests for potassium levels
  • Examination of muscle reflexes if they are reduced
  • Electrocardiography if a patient may experience any symptoms related to heart

So above mentioned are some of the diagnostic steps that a physician may perform to diagnose Hyperkalemic periodic paralysis.


As we read earlier the condition is hereditary and there is a mutation in the genes named CACNA1S and SCN4A. As per ayurveda the hereditary condition is correlated to beej dushti, so let’s discuss what beej dushti is? Beej dushti is the defect in beejbhaga that is the sperm and ovum. Ashuddha shukra (defected sperm) and ashuddha artava (defected ovum) are the main causes of beej dushti. If there is any defect in the gametes (sperm and ovum) of parents then the child should inherit the disease. If we see on the side of dosha pacification then there is the vitiation of vata dosha as it is responsible for any movement and functioning control in the body. Hypokalemic Periodic Paralysis is a genetic condition so we should not cure it but will manage the symptoms of this condition with certain herbal remedies and improve the quality of the patient.


Planet Ayurveda is a GMP certified clinic which formulates various herbal supplements for maintaining the overall health as well as alleviating any kind of health issue. The formulations produced by Planet Ayurveda are produced under the strict observance of M.D. Ayurveda practitioners. All the herbal supplements are free from any kind of preservatives, additives, fillers, color, starch, resins and other synthetic material. For the purpose of managing the symptoms of Hypokalemic Periodic Paralysis Planet Ayurveda provides 7 herbal remedies that we will discuss further in detail.




Ras Rajeshwar Ras is an ayurvedic formulation that has been used for maintaining the health of the nervous system. It consists of ingredients like swarna yukta rasraj ras, ashwagandha (Withania somnifera), guggul (Commiphora mukul) and some others. The ingredients of this formulation contain miraculous vata pacifying balya (strengthening) properties. Due to its properties Rasarajeshwar Rasa aids in promoting the normal functioning of the nervous system as well as strengthening the weakened muscles in case of Hypokalemic Periodic Paralysis.

Dosage: 1 tablet twice daily to be chewed.


Ashwagandhaghan vati is a formulation by Planet Ayurveda which is available in tablet form. These herbal tablets consist of Ashwagandha herb (Withania somnifera) that is an effective adaptogenic herb in nature. The adaptogenic properties of ashwagandha helps in reducing stress in the body which further prevents the damage at cellular level. So for preventing the damage of muscle cells Ashwagandhaghan vati is useful in the management of Hypokalemic Periodic Paralysis.

Dosage: 2 tablets twice daily with plain water after meals.


Musli Strength Capsules by Planet Ayurveda is a herbal remedy which consists of the standardized extract of two herbs that are safed musli (Chlorophytum borivilianum) and gokshura (Tribulus terrestris). The capsules consist of various properties such as antioxidant, adaptogenic, strengthening, immune boosting and rejuvenating. All these properties make these herbal capsules effective in managing the symptoms of Hypokalemic Periodic Paralysis. It strengthens the weak muscles, promotes the functioning of the skeletal muscles, prevents the degeneration of the skeletal muscle cells as well as prevents from the stage of paralysis.

Dosage: 1 capsule twice daily with plain water after meals.            


Gandhak Rasayan is an ayurvedic formulation that is formulated by Planet Ayurveda under the strict observance of M.D. Ayurveda practitioners. It consists of shuddha gandhak (purified sulphur) which has been used since ancient times in the field of ayurveda for managing several disorders. It is a natural immunity booster, so by boosting the immunity levels this remedy assists in alleviating the muscle weakness associated with Hypokalemic Periodic Paralysis.

Dosage: 2 tablets twice daily with plain water after meals.


Amrit kalash is an ayurvedic formulation that is one of the best rasayana (rejuvenators). Rasayana are the ones that are believed to enhance the resistance of the body towards various infections as well as diseases. Rasayana are considered as effective in enhancing the longevity of life by promoting overall health. Amrit kalash promotes nervous health by pacifying vata dosha and helps in promoting the functioning of skeletal muscles. This rasayana formulation alleviates the weakness of muscles by increasing the reduced contraction, so it is quite effective in the management of Hypokalemic Periodic paralysis.

Dosage: 1 tsp twice daily with plain water after meals.  


Brahma Rasayan is one of the best ayurvedic health supplements which is available in lehya (jam) form. Usually this ayurvedic health supplement is used in various nervous disorders and associated conditions such as anxiety, cognition issues, lack of concentration, etc. As in case of hypokalemic periodic paralysis there is the reduction of contraction of skeletal muscles which leads to their weakness and if not treated later on leads to paralysis of skeletal muscles. The consumption of Brahma Rasayan increases the contraction of skeletal muscles which further reduces the weakness in the muscles.

Dosage: 1 tsp twice daily with plain water twice daily.


Green essentials is a herbal remedy formulated by Planet Ayurveda in capsule form under the observance of M.D. Ayurveda practitioners. These capsules are polyherbal and consist of standardized extracts like grape seed (Vitis vinifera), wheat grass (Triticulum aestivum), spirulina (Spirulina platensis) and some others. These capsules are considered as one of the best immunity booster due to mention of ingredients. Also the antioxidant properties present in these capsules prevent the damage of nerve cells and muscle cells which further prevents paralysis of the skeletal muscles.

Dosage: 2 capsules twice daily with plain water after meals.



Hypokalemic periodic paralysis, a condition associated with low levels of potassium and includes episodes of severe muscle weakness that generally begins in childhood or at the adolescent age. It is one of the genetic disorders in which there is a mutation in the gene named CACNA1S and SCN4A. In this case a person may experience weakness in muscles, cramping in muscles, heart palpitations, most oftenly the muscles involved are shoulders, arms, legs and hips and at last paralysis. As per ayurveda the hereditary condition is correlated to beej dushti in which there is a defect in beejbhaga that is the sperm and ovum. Don’t worry the condition is manageable with ayurvedic medications and for this purpose Planet Ayurveda provides various herbal remedies that are free from any kind of additives and preservatives. So without worrying you can start taking treatment from Planet Ayurveda and while consuming remedies if you have any query then you can share your query on